Fast Breath-Hold T2-Weighted MRI of the Kidney by Means of Half-Fourier Single-Shot Turbo Spin Echo: Comparison with High Resolution Turbo Spin Echo Sequence

Nakayama, Yoshiharu; Yamashita, Yasuyuki; Matsuno, Yasuharu; Namimoto, Tomohiro; Kadota, Masataka; Mitsuzaki, Katsuhiko; Abe, Yasuko; Katahira, Kentaro; Arakawa, Akihiko; Takahashi, Manabu

doi:10.1097/00004728-200101000-00010

Cited by 15 publications

(13 citation statements)

References 15 publications

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“…MRI was performed with a pre-specified protocol using the following sequences: T2 SSFSE (T2 weighted sequence single-shot fast spin-echo), also called half-Fourier single-shot turbo spin-echo (or HASTE for Siemens), and SSFSE TE long (Single-shot fast spin echo with long echo time). T2 SSFSE is an ultrafast MRI technique with a short acquisition time less susceptible to motion respiratory artifact than other techniques such as echo T2-weighted imaging (Nakayama et al, 2001). SSFSE TE long is a highly T2 weighted sequence allowing an optimal contrast between microcysts and renal parenchyma.…”

Section: Data Collection and Measurementsmentioning

confidence: 99%

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Determinants of Kidney Function and Accuracy of Kidney Microcysts Detection in Patients Treated With Lithium Salts for Bipolar Disorder

et al. 2022

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Objectives: Early kidney damage during lithium treatment in bipolar disorder is still hypothetical. We aimed at identifying the determinants of a decreased measured glomerular filtration rate (mGFR) and the accuracy of kidney MRI imaging in its detection.Methods: In this cross-sectional cohort study, 217 consecutive lithium-treated patients underwent mGFR and kidney MRI with half-Fourier turbo spin-echo and Single-shot with long echo time sequences.Results: Median age was 51 [27–62] years, and median lithium treatment duration was 5 [2–14] years. 52% of patients had a stage 2 CKD. In multivariable analysis, the determinants of a lower mGFR were a longer lithium treatment duration (β −0.8 [−1; −0.6] ml/min/1.73 m2 GFR decrease for each year of treatment), a higher age (β −0.4 [−0.6; −0.3] ml/min/1.73 m2 for each year of age, p < 0.001), albuminuria (β −3.97 [−6.6; −1.3], p = 0.003), hypertension (β −6.85 [−12.6; −1.1], p = 0.02) and hypothyroidism (β −7.1 [−11.7; −2.5], p = 0.003). Serum lithium concentration was not associated with mGFR. Renal MRI displayed renal microcyst(s) in 51% of patients, detected as early as 1 year after lithium treatment initiation. mGFR and lithium treatment duration were strongly correlated in patients with microcyst(s) (r = −0.64, p < 0.001), but not in patients with no microcysts (r = −0.24, p = 0.09). The presence of microcysts was associated with the detection of an mGFR <45 ml/min/1.73 m2 (AUC 0.893, p < 0.001, sensitivity 80%, specificity 81% for a cut-off value of five microcysts).Conclusion: Lithium treatment duration and hypothyroidism strongly impacted mGFR independently of age, especially in patients with microcysts. MRI might help detect early lithium-induced kidney damage and inform preventive strategies.

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Section: Data Collection and Measurementsmentioning

confidence: 99%

“…SSFSE TE long is a highly T2 weighted sequence allowing an optimal contrast between microcysts and renal parenchyma. This MRI protocol has proven useful in depicting structures containing static fluids including cystic lesions, characterized as T2 hyperintense round areas (Nakayama et al, 2001).…”

Section: Data Collection and Measurementsmentioning

confidence: 99%

Determinants of Kidney Function and Accuracy of Kidney Microcysts Detection in Patients Treated With Lithium Salts for Bipolar Disorder

et al. 2022

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Section: Kidney Mrimentioning

confidence: 99%

Kidney function and long-term treatment with lithium salts for bipolar disorder Determinants of mGFR and accuracy of kidney microcysts detection in the diagnosis of CKD

Tabibzadeh

Faucon

Vidal‐Petiot

et al. 2021

Preprint

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Background and objectives. Kidney damage during early stages of lithium treatment in bipolar disorder is still hypothetical. We aimed at identifying the determinants of a decreased measured glomerular filtration rate (mGFR) and the accuracy of kidney MRI imaging in its detection. Design, setting, participants and measurements. Cross sectional cohort study. Systematic evaluation including mGFR of 217 consecutive adult patients treated with lithium carbonate. Kidney MRI imaging in 99 patients with half-Fourier turbo spin-echo and Single-shot with long echo time sequences. Results. Median age was 51 [27-62] years, and median lithium treatment duration was 5 [2-14] years. 52% of patients had a stage 2 CKD. In multivariable analysis, the determinants of a lower mGFR were a longer lithium treatment duration (beta -0.8 [-1; -0.6] ml/min/1.73m2 GFR decrease for each year of treatment), a higher age (beta -0.4 [-0.6; -0.3] ml/min/1.73m2 for each year of age, p<0.001), albuminuria (beta -3.97 [-6.6;-1.3], p=0.003), hypertension (beta -6.85 [-12.6;-1.1], p=0.02) and hypothyroidism (beta -7.1 [-11.7;-2.5], p=0.003). Serum lithium concentration was not associated with mGFR. Patients with mGFR<60 ml/min/1.73m2 (22%) had a higher prevalence and number of renal microcysts. Renal MRI displayed renal microcyst(s) in 51% of patients, detected as early as one year after lithium treatment initiation. mGFR and lithium treatment duration were strongly correlated in patients with microcyst(s) (r=-0.64, p<0.001), but not in patients with no microcysts (r=-0.24, p=0.09). The presence of microcysts was associated with the detection of an mGFR <45 ml/min/1.73m2 (AUC 0.893, p<0.001, sensitivity 80%, specificity 81% for a cut-off value of 5 microcysts). Conclusions. Besides usual risk factors of GFR decrease, lithium treatment duration strongly impacted mGFR independently of age, especially in patients with microcysts. Hypothyroidism was also negatively associated with kidney function in these patients. MRI might help detect early lithium-induced kidney damage and inform preventive strategies.

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“…15 Compared to standard TSE, ss-TSE provides improved spatial and contrast resolution, less artefacts, and time efficiency. 15 Three-plane acquisition is advised because the visibility of small renal lesions may depend on renal orientation (Fig 3). Image blur with ss-TSE is ameliorated with PI.…”

Section: Figurementioning

confidence: 99%

Multiparametric MRI of solid renal masses: pearls and pitfalls

et al. 2015

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Fast Breath-Hold T2-Weighted MRI of the Kidney by Means of Half-Fourier Single-Shot Turbo Spin Echo: Comparison with High Resolution Turbo Spin Echo Sequence

Abstract: The HASTE sequence generates high contrast images and is free of motion and chemical shift artifacts, with much better time efficacy. The sequence provides comparable diagnostic information to TSE sequences.

Cited by 15 publications

References 15 publications

Determinants of Kidney Function and Accuracy of Kidney Microcysts Detection in Patients Treated With Lithium Salts for Bipolar Disorder

Determinants of Kidney Function and Accuracy of Kidney Microcysts Detection in Patients Treated With Lithium Salts for Bipolar Disorder

Kidney function and long-term treatment with lithium salts for bipolar disorder Determinants of mGFR and accuracy of kidney microcysts detection in the diagnosis of CKD

Multiparametric MRI of solid renal masses: pearls and pitfalls

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