Fast cleavage of a diselenide induced by a platinum(II)–methionine complex and its biological implications

Liu, Qin; Wang, Xiaoyong; Yang, Xiaoliang; Liang, Xiao; Guo, Zijian

doi:10.1016/j.jinorgbio.2010.07.007

Cited by 11 publications

(7 citation statements)

References 38 publications

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“…Purified 16 , as for 14 , did not disproportionate on storage. Other types of selenylations of the GSH thiol have been reported recently, among these GSH pseudoglycosylation with a glycosyl diselenide [ 32 ], selenylation of GSH with ebselen [ 33 ], selenylation with selenocysteine [ 34 ], and selenylation of GSH with various electrophilic selenoallyl species [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

Biohybrid -Se-S- Coupling Reactions of an Amino Acid Derived Seleninate

2013

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We describe the synthesis of the N-(2-seleninatoethyl) amide of N-Boc-phenylalanine, serving here as a peptide model, and its reductive coupling reactions under mild conditions with unprotected thiouridine and glutathione. Selenosulfide products such as these comprise reversibly conjugated bio-components, and can potentially find uses as probes of biological function, such as enzyme inhibitors, delivery systems, or structural mimics.

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Section: Resultsmentioning

confidence: 99%

Biohybrid -Se-S- Coupling Reactions of an Amino Acid Derived Seleninate

2013

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“…In CSV, the SeCyst signal was attributed to its reduction after the formation of a mercuro−selenocystinate film. 9 On the basis of SeCyst pK a values (pK 1 1.68, pK 2 2.15, pK 3 8.07, pK 4 8.94), 21,22 different species may be present in aqueous solutions (see distribution diagram in Figure 1b). SeCyst carries two positive charges at very low pH (located on both protonated amino groups) and one positive charge at low pH and becomes zwitterionic at intermediate pH values.…”

Section: Resultsmentioning

confidence: 99%

“…Arrow indicates the signal tendency when changing pH. (b) Distribution of SeCyst species as a function of pH, computed using the acidity constants taken from refs and . Overlaid are the E p values of the anodic process related to SeCyst.…”

Section: Resultsmentioning

confidence: 99%

Chemometric Analysis of Voltammetric Data on Metal Ion Binding by Selenocystine

et al. 2012

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The behavior of selenocystine (SeCyst) alone or in the presence of various metal ions (Bi(3+), Cd(2+), Co(2+), Cu(2+), Cr(3+), Ni(2+), Pb(2+), and Zn(2+)) was studied using differential pulse voltammetry (DPV) over a wide pH range. Voltammetric data matrices were analyzed using chemometric tools recently developed for nonlinear data: pHfit and Gaussian Peak Adjustment (GPA). Under the experimental conditions tested, no evidence was found for the formation of metal complexes with Bi(3+), Cu(2+), Cr(3+), and Pb(2+). In contrast, SeCyst formed electroinactive complexes with Co(2+) and Ni(2+) and kinetically inert but electroactive complexes with Cd(2+) and Zn(2+). Titrations with Cd(2+), Co(2+), Ni(2+), and Zn(2+) produced data that were reasonably consistent with the formation of stable 1:1 M(SeCyst) complexes.

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“…Selenium can act as a ligand to coordinate with different metals. , Complexes formed by coordination between selenium and metals showed special chemical and biological properties. We studied the coordination between selenium-containing polymer and platinum and introduced the competitive coordination mechanism into the construction of drug delivery systems .…”

Section: Selenium-containing Polymers As Promising Biomaterialsmentioning

confidence: 99%

Selenium-Containing Polymers: Perspectives toward Diverse Applications in Both Adaptive and Biomedical Materials

Xia

et al. 2018

Macromolecules

135

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Selenium is a semimetallic element lying in group XVI of the periodic table with its chemical properties resembling sulfur. But owing to its relatively low electronegativity and large atomic radius compared with sulfur, selenium also shows unique properties. This feature endows selenium-containing compounds with high reactivity and sensitivity. Although organic selenium chemistry has been developing very fast, the successful introduction of selenium into polymer science is rather scarce. Fortunately, we have seen a drastic rising trend in the area of selenium-containing polymers over the past decade. In this Perspective, the synthetic routes of selenium-containing polymers are summarized, and their unique stimuli-responsive properties are elaborated on, together with their diverse applications in the field of adaptive and biomedical materials.

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Fast cleavage of a diselenide induced by a platinum(II)–methionine complex and its biological implications

Cited by 11 publications

References 38 publications

Biohybrid -Se-S- Coupling Reactions of an Amino Acid Derived Seleninate

Biohybrid -Se-S- Coupling Reactions of an Amino Acid Derived Seleninate

Chemometric Analysis of Voltammetric Data on Metal Ion Binding by Selenocystine

Selenium-Containing Polymers: Perspectives toward Diverse Applications in Both Adaptive and Biomedical Materials

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