H.265/HEVC achieves an average bitrate reduction of 50% for fixed video quality compared with the H.264/AVC standard, while computation complexity is significantly increased. The purpose of this work is to improve coding efficiency for the next-generation video-coding standards. Therefore, by developing a novel spatial neighborhood subset, efficient spatial correlation-based motion vector prediction (MVP) with the coding-unit (CU) depth-prediction algorithm is proposed to improve coding efficiency. Firstly, by exploiting the reliability of neighboring candidate motion vectors (MVs), the spatial-candidate MVs are used to determine the optimized MVP for motion-data coding. Secondly, the spatial correlation-based coding-unit depth-prediction is presented to achieve a better trade-off between coding efficiency and computation complexity for interprediction. This approach can satisfy an extreme requirement of high coding efficiency with not-high requirements for real-time processing. The simulation results demonstrate that overall bitrates can be reduced, on average, by 5.35%, up to 9.89% compared with H.265/HEVC reference software in terms of the Bjontegaard Metric.