“…In this approach, a causal MRF model, called Quadrilateral Markov Random Field (QMRF), was used to compute image spatial information under the definition of Shannon entropy. The spatial entropy defined in [6] was further simplified for homogenous but anisotropic QMRF in [29] for nearest neighboring structures as per the following equation: \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$$\eqalignno{&H({{\bf X}})=mn(H(X,X_{u})+H(X,X_{l})\cr&~~\quad\qquad-H(X))-{{mn}\over{2}}(H(X_{u},X_{l})+H(X_{u},X_{r}))&{\hbox{(5)}}}$$\end{document} where \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$m\times n$\end{document} denotes the image size, \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$H(X,X_{u})$\end{document} the joint entropy of a voxel with its upper neighbor, \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$H(X,X_{l})$\end{document} the joint entropy of a voxel with its left neighbor, \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$H(X_{u},X_{l})$\end{document} the joint entropy of the left and upper neighbors, and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} }{}$H(X_{u},X_{r})$\end{document} the joint entropy of the right and upper neighbors; see Fig. 2 .…”