“…On the contrary, physics-based models can approximate the non-linear behaviour of soft tissue much more accurately [20], but their high computational load and storage requirements do not allow them to be computed in real time [22]. These include mass-spring models (MSM) [13,16,21,22], the boundary element method (BEM) [20,23], the meshless method [18] and the widely used Finite Element Method (FEM) [8,24,25]. Table 1 summarises the capabilities of the aforementioned approaches in terms of accuracy, real-time computation, and adaptability to topological changes -meaning how easily the model can be updated intra-operatively when the anatomy is altered.…”