Fast delivery of melatonin from electrospun blend polyvinyl alcohol and polyethylene oxide (PVA/PEO) fibers

Emerine, Rachel; Chou, Shih-Feng

doi:10.3934/bioeng.2022013

Cited by 7 publications

(4 citation statements)

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“…In contrast, cumulative IBP release gradually increased to 75.5 ± 4.1% and 95.9 ± 0.9% at 1 h and 2 h time points for PCL control fibers, respectively. Studies demonstrated the fast release characteristics of small molecule drugs after incorporation of poloxamer 407 in electrospun hydrophilic fibers, due to the surface wetting and improvement in dissolution of poorly water-soluble drugs [ 14 , 57 ]. In general, poloxamer promoted the wettability of hydrophobic PCL fibers to facilitate the release of small molecule model drugs.…”

Section: Resultsmentioning

confidence: 99%

Effects of Poloxamers as Excipients on the Physicomechanical Properties, Cellular Biocompatibility, and In Vitro Drug Release of Electrospun Polycaprolactone (PCL) Fibers

2023

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Electrospun microfibers are emerging as one of the advanced wound dressing materials for acute and/or chronic wounds, especially with their ability to carry drugs and excipients at a high loading while being able to deliver them in a controlled manner. Various attempts were made to include excipients in electrospun microfibers as wound dressing materials, and one of them is poloxamer, an amphiphilic polymer that exhibits wound debridement characteristics. In this study, we formulated two types of poloxamers (i.e., P188 and P338) at 30% (w/w) loading into electrospun polycaprolactone (PCL) fibers to evaluate their physicomechanical properties, biocompatibility, and in vitro drug release of a model drug. Our findings showed that the incorporation of poloxamers in the PCL solutions during electrospinning resulted in a greater “whipping” process for a larger fiber deposition area. These fibers were mechanically stiffer and stronger, but less ductile as compared to the PCL control fibers. The incorporation of poloxamers into electrospun PCL fibers reduced the surface hydrophobicity of fibers according to our water contact angle studies and in vitro degradation studies. The fibers’ mechanical properties returned to those of the PCL control groups after “dumping” the poloxamers. Moreover, poloxamer-loaded PCL fibers accelerated the in vitro release of the model drug due to surface wettability. These poloxamer-loaded PCL fibers were biocompatible, as validated by MTT assays using A549 cells. Overall, we demonstrated the ability to achieve a high loading of poloxamers in electrospun fibers for wound dressing applications. This work provided the basic scientific understanding of materials science and bioengineering with an emphasis on the engineering applications of advanced wound dressings.

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Section: Resultsmentioning

confidence: 99%

Effects of Poloxamers as Excipients on the Physicomechanical Properties, Cellular Biocompatibility, and In Vitro Drug Release of Electrospun Polycaprolactone (PCL) Fibers

2023

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“…SEM micrographs were captured from 10 mm working distance, at an accelerating voltage of 15 kV. Using the ImageJ software, the average NF diameter (AD, mean ± SD) was determined, based on at least 50 measurements, from different locations of micrographs [ 32 ].…”

Section: Methodsmentioning

confidence: 99%

Preparation, Characterization, and Antioxidant Activity of L-Ascorbic Acid/HP-β-Cyclodextrin Inclusion Complex-Incorporated Electrospun Nanofibers

Khan

Singh

Saneja

2023

Foods

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L-Ascorbic acid (LAA) is a key vitamin, implicated in a variety of physiological processes in humans. Due to its free radical scavenging activity, it is extensively employed as an excipient in pharmaceutical products and food supplements. However, its application is greatly impeded by poor thermal and aqueous stability. Herein, to improve the stability and inhibit oxidative degradation, we prepared LAA-cyclodextrin inclusion complex-incorporated nanofibers (NFs). The continuous variation method (Job plot) demonstrated that LAA forms inclusions with hydroxypropyl-β-cyclodextrin (HP-β-CD) at a 2:1 molar stoichiometric ratio. The NFs were prepared via the single step electrospinning technique, without using any polymer matrix. The solid-state characterizations of LAA/HP-β-CD-NF via powder x-ray diffractometry (PXRD), Fourier-transform infrared (FT-IR) analysis, differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), and nuclear magnetic resonance (1H NMR and 2D-NOESY) spectroscopy, reveal the effective encapsulation of the LAA (guest molecule) inside the HP-β-CD (host) cavity. The SEM micrograph reveals an average fiber diameter of ~339 nm. The outcomes of the thermal investigations demonstrated that encapsulation of LAA within HP-β-CD cavities provides improved thermal stability of LAA (by increasing the thermal degradation temperature). The radical scavenging assay demonstrated the enhanced antioxidant potential of LAA/HP-β-CD-NF, as compared to native LAA. Overall, the study shows that cyclodextrin inclusion complex-incorporated NFs, are an effective approach for improving the limitations associated with LAA, and provide promising avenues in its therapeutic and food applications.

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“…Electrospinning is a simple, robust, and cost-effective method to produce drug-containing fibers with diameters ranging from tens of nanometers to several micrometers (Chou et al, 2015;Emerine and Chou, 2022). The result is a layer of non-woven fiber mesh that exhibits the texture of typical textiles with a porous structure allowing drainage of the wound exudates and permeation of atmospheric oxygen to the wound (Saghazadeh et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Fabrication of drug-eluting polycaprolactone and chitosan blend microfibers for topical drug delivery applications

2023

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Chronic and non-healing wounds show delayed and incomplete healing process, which expose the patients to a high risk of infection. These types of wounds require frequent change of dressing, which is a burden on the patients. In addition, ideal dressing needs to meet the requirements in minimizing microbial infiltration and growth while balancing moisture and exchanging oxygen with outside environment. To overcome the challenge in frequent change of dressing and meet the design requirements, current researches have focused on the development of electrospun fibers with incorporation of small molecule drugs for sustained release purpose. In this study, electrospinning was performed to fabricate blend fibers consisting of 15 wt% of polycaprolactone (PCL) and 4 wt% of chitosan (CS) at various blend ratios with the incorporation of a model small molecule drug, acetylsalicylic acid (ASA). Results showed that fibers became more hydrophilic when increasing CS concentration from 0% to 60% in PCL/CS blank fibers. Increasing CS concentration decreased fiber diameter resulting in the decrease of fiber mechanical properties. Furthermore, the addition of 10% w/w ASA also made the fibers more hydrophilic and further decreased the fiber diameter. There were no linear relationships between CS concentrations and fiber mechanical properties in the drug-loaded samples, which indicated some level of drug-polymer interactions. Fiber mechanical properties and drug release rates were two major aspects indicative of strong and/or weak drug-polymer interactions. In vitro drug release in PBS buffer solution showed a burst profile of ASA (30%) up to 2 h followed by a zero-order release rate up to 2 days.

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Fast delivery of melatonin from electrospun blend polyvinyl alcohol and polyethylene oxide (PVA/PEO) fibers

Cited by 7 publications

References 0 publications

Effects of Poloxamers as Excipients on the Physicomechanical Properties, Cellular Biocompatibility, and In Vitro Drug Release of Electrospun Polycaprolactone (PCL) Fibers

Effects of Poloxamers as Excipients on the Physicomechanical Properties, Cellular Biocompatibility, and In Vitro Drug Release of Electrospun Polycaprolactone (PCL) Fibers

Preparation, Characterization, and Antioxidant Activity of L-Ascorbic Acid/HP-β-Cyclodextrin Inclusion Complex-Incorporated Electrospun Nanofibers

Fabrication of drug-eluting polycaprolactone and chitosan blend microfibers for topical drug delivery applications

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