Fast detection of paracetamol on a gold nanoparticle–chitosan substrate by SERS

Santos, Elias de Barros; Lima, Elaine Cristina Nogueira Lopes; Oliveira, Cristine Santos de; Sígoli, Fernando Aparecido; Mazali, Ítalo Odone

doi:10.1039/c4ay00635f

Cited by 45 publications

(26 citation statements)

References 35 publications

(47 reference statements)

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“…Motivated by this, we tested the newly developed sensing platform with analyte-enrichment system towards SERS-based detection of 7 widely used biologically active organic compounds dissolved in distilled water at 10 −8 M concentration: Pefloxacin, Ciprofloxacin, Levofloxacin, Diphenhydramine hydrochloride, Ibuprofen, Diclofenac, and 4-Acetamidophenol. SERS spectra of the tested drugs are shown in Figure 5, indicating the ability of the developed sensor to identify their main characteristic fingerprints (at corresponding concentration of 1.5-3 ppb), which were found to be in good agreement with the spectral position of their Raman bands previously reported for similar analytes [68][69][70][71][72][73][74].…”

Section: Sers Performance Of the Plasmonic Sensor With Analyte Enrichsupporting

confidence: 81%

Ultrasensitive SERS-Based Plasmonic Sensor with Analyte Enrichment System Produced by Direct Laser Writing

et al. 2019

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We report an easy-to-implement device for surface-enhanced Raman scattering (SERS)-based detection of various analytes dissolved in water droplets at trace concentrations. The device combines an analyte-enrichment system and SERS-active sensor site, both produced via inexpensive and high-performance direct femtosecond (fs)-laser printing. Fabricated on a surface of water-repellent polytetrafluoroethylene substrate as an arrangement of micropillars, the analyte-enrichment system supports evaporating water droplet in the Cassie–Baxter superhydrophobic state, thus ensuring delivery of the dissolved analyte molecules towards the hydrophilic SERS-active site. The efficient pre-concentration of the analyte onto the sensor site based on densely arranged spiky plasmonic nanotextures results in its subsequent label-free identification by means of SERS spectroscopy. Using the proposed device, we demonstrate reliable SERS-based fingerprinting of various analytes, including common organic dyes and medical drugs at ppb concentrations. The proposed device is believed to find applications in various areas, including label-free environmental monitoring, medical diagnostics, and forensics.

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Section: Sers Performance Of the Plasmonic Sensor With Analyte Enrichsupporting

confidence: 81%

Ultrasensitive SERS-Based Plasmonic Sensor with Analyte Enrichment System Produced by Direct Laser Writing

et al. 2019

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“…The LOD for SERS of paracetamol on AuNP@AlF is about 9-times lower than the lowest reported LOD of 1 mM detected with SERS spectroscopy method, to the best of our knowledge. 22 …”

Section: Discussionmentioning

confidence: 99%

“…This LOD is 0.11 mM, which is about an order of magnitude lower than the LOD reported for paracetamol SERS detection on a gold nanoparticle-chitosan substrate. 22 We also calculated the LOQ, using formula (2) and the same standard deviation of the blank, slope and intercept. The LOQ for paracetamol is 0.7 mM AFM mapping of the AuNPs@AlF substrate with 0.0625 mM paracetamol sample was performed to evaluate the degree of nanoparticle association in the assay.…”

Section: Detection Of Paracetamolmentioning

confidence: 99%

“…21 While SERS detection of both urea and paracetamol 22 has been already reported in the literature, a direct comparision of commercial AuNPs@Al foil with those SERS substrates is possible. Hovewer, we still prepared, measured and analyzed data obtained with self-developed AuNPs@ evaporated Au film and AuNPs@glass slides as two control substrates for the detection of urea in artificial urine.…”

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confidence: 99%

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Detection of Paracetamol in Water and Urea in Artificial Urine with Gold Nanoparticle@AI Foil Cost-efficient SERS Substrate

et al. 2018

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We demonstrated that a cost-efficient, easy to prepare, hybrid SERS substrate-gold nanoparticles (AuNPs) on untreated Al foil (AlF) can effectively detect pharmaceuticals, such as paracetamol and clinical biomarkers, like urea in artificial urine. The limit of detection (LOD) for paracetamol on AuNPs on AlF is superior (0.1 vs. 1 mM ) to the LOD reported for SERS detection of paracetamol in the literature. For SERS detection of urea in urine, AuNPs on both Al foil and Au film performed much better than AuNPs on glass, in terms of the concentration range, linearity and LOD. However, assay on AuNPs on AlF showed a better semi-logarithmic trendline with R 2 = 0.98 than an assay on AuNPs on Au film with R 2 = 0.94. They have comparable sensitivity with LOD 0.024 and 0.017 M, respectively. The limit of quantification (LOQ) of the former is 0.026 M, which makes it sufficient for the quantification of urea in urine at both normal and pathophysiological (0.03 -0.15 M) concentration.

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“…High-resolution transmission electron microscopy (HRTEM) is a variant of TEM with resolutions below 0.5 Å [159] which facilitates the imaging of specimens at an atomic scale and enables the analysis of the atomic structure of the samples [159]. HRTEM has been an invaluable asset in the analysis of biopolymer-assisted formation of nanoparticles including the study of their crystal planes [160][161][162], the crystal structure of cellulose [163], nanocomposites [164,165], and even in the molecular orientations of biopolymers [166]. TEM with resolutions below 0.5 Å [159] which facilitates the imaging of specimens at an atomic scale and enables the analysis of the atomic structure of the samples [159].…”

Section: Transmission Electron Microscopymentioning

confidence: 99%

Microscopic Techniques for the Analysis of Micro and Nanostructures of Biopolymers and Their Derivatives

et al. 2020

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Natural biopolymers, a class of materials extracted from renewable sources, is garnering interest due to growing concerns over environmental safety; biopolymers have the advantage of biocompatibility and biodegradability, an imperative requirement. The synthesis of nanoparticles and nanofibers from biopolymers provides a green platform relative to the conventional methods that use hazardous chemicals. However, it is challenging to characterize these nanoparticles and fibers due to the variation in size, shape, and morphology. In order to evaluate these properties, microscopic techniques such as optical microscopy, atomic force microscopy (AFM), and transmission electron microscopy (TEM) are essential. With the advent of new biopolymer systems, it is necessary to obtain insights into the fundamental structures of these systems to determine their structural, physical, and morphological properties, which play a vital role in defining their performance and applications. Microscopic techniques perform a decisive role in revealing intricate details, which assists in the appraisal of microstructure, surface morphology, chemical composition, and interfacial properties. This review highlights the significance of various microscopic techniques incorporating the literature details that help characterize biopolymers and their derivatives.

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Fast detection of paracetamol on a gold nanoparticle–chitosan substrate by SERS

Abstract: A fast method for detecting pharmaceutical drugs, such as paracetamol, by surface-enhanced Raman spectroscopy (SERS) using a gold nanoparticle substrate was studied.

Cited by 45 publications

References 35 publications

Ultrasensitive SERS-Based Plasmonic Sensor with Analyte Enrichment System Produced by Direct Laser Writing

Ultrasensitive SERS-Based Plasmonic Sensor with Analyte Enrichment System Produced by Direct Laser Writing

Detection of Paracetamol in Water and Urea in Artificial Urine with Gold Nanoparticle@AI Foil Cost-efficient SERS Substrate

Microscopic Techniques for the Analysis of Micro and Nanostructures of Biopolymers and Their Derivatives

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