Fast dissolving oral films for drug delivery prepared from chitosan/pullulan electrospinning nanofibers

Qin, Zeyu; Jia, Xiwen; Liu, Qian; Kong, Bing; Wang, Hao

doi:10.1016/j.ijbiomac.2019.06.224

Cited by 202 publications

(68 citation statements)

References 43 publications

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“…Electrospun fiber can realize the burst release, stable release, pulsating release, delayed release, and two-phase release of drugs mainly because of its strong carrying capacity, high packaging efficiency, strong expansibility, simple preparation, and low cost (160). Qin et al (161) dissolved aspirin in chitin/pullulan spinning solution and obtained fast dissolving oral films (FDOFs) by electrospinning. Within 60 s, the FDOFs fully dissolve in water, thereby rapidly releasing the template drug aspirin and successfully demonstrating its potential in the oral mucosal release system.…”

Section: Functional Applications Of Structural Electrospun Fibersmentioning

confidence: 99%

Structural design toward functional materials by electrospinning: A review

et al. 2020

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Electrospinning as one of the most versatile technologies have attracted a lot of scientists’ interests in past decades due to its great diversity of fabricating nanofibers featuring high aspect ratio, large specific surface area, flexibility, structural abundance, and surface functionality. Remarkable progress has been made in terms of the versatile structures of electrospun fibers and great functionalities to enable a broad spectrum of applications. In this article, the electrospun fibers with different structures and their applications are reviewed. First, several kinds of electrospun fibers with different structures are presented. Then the applications of various structural electrospun fibers in different fields, including catalysis, drug release, batteries, and supercapacitors, are reviewed. Finally, the application prospect and main challenges of electrospun fibers are discussed. We hope that this review will provide readers with a comprehensive understanding of the structural design and applications of electrospun fibers in different fields.

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Section: Functional Applications Of Structural Electrospun Fibersmentioning

confidence: 99%

Structural design toward functional materials by electrospinning: A review

et al. 2020

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“…49 Mascheroni et al 10 reported that this pullulan presents a good stability up to temperatures near 200ºC, however, small peaks were evident in a temperature range from 265ºC to 300ºC. According to Qin et al 50 pullulan exhibits weight Figure 2. FTIR spectra of (a) pure PCL, pure PMS and PCL/PMS membrane; (b) pure PCL, pure β-glucan and PCL/β-glucan membrane; and (c) pure PCL, pure pullulan and PCL-pullulan-PCL multilayer membrane.…”

Section: Differential Scanning Calorimetrymentioning

confidence: 94%

Ultrathin single and multiple layer electrospun fibrous membranes of polycaprolactone and polysaccharides

Rodríguez-Sánchez

Vergara-Villa

Clavijo-Grimaldo

et al. 2020

Journal of Bioactive and Compatible Polymers

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Electrospinning was used to produce fibrous membranes, in single and multiple layers, from poly(ε-caprolactone), pullulan, and from mixtures of poly(ε-caprolactone) with potato modified starch and β-glucan. It was possible to obtain single-layer membranes from solutions of pullulan in water, poly(ε-caprolactone) in chloroform, and from mixtures of poly(ε-caprolactone)/β-glucan and poly(ε-caprolactone)/potato modified starch in chloroform. Scanning electron microscopy images showed the formation of ultrathin homogeneous fibers from electrospun poly(ε-caprolactone) and pullulan, whereas the fibers obtained from mixtures of poly(ε-caprolactone)/ β -glucan and poly(ε-caprolactone)/potato modified starch had different sizes and morphologies, as well as irregular microstructures, characterized by the presence of beads. Contact angle analyses showed that pullulan membranes were extremely hydrophilic, while poly(ε-caprolactone) membranes were predominantly hydrophobic. Subsequently, poly(ε-caprolactone)-pullulan-poly(ε-caprolactone) multilayer membranes, with intermediate wettability, were prepared by successive electrospinning steps. Infrared spectroscopy and calorimetric analyses showed the presence of both polymers and the absence of changes in their structure and stability due to electrospinning, indicating adequate compatibility between the two polymers. We foresee that the polyester-polysaccharide multilayer membrane might be used as a biodegradable vehicle for active agents with different hydrophobicity, with applications as food packaging and biocompatible scaffold materials.

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“…The choice of excipients and solvents in pediatric formulations is subjected to critical screening, avoiding those potentially toxic or unsuitable for children. Several studies have reported the fabrication of electrospun ODFs from synthetic polymers in non-aqueous solvents [22][23][24] or aqueous solutions [25], though there are only a few examples of natural polymers such as polysaccharides, proteins and cellulose derivatives electrospun to ODFs from aqueous solutions [26].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Orodispersible Films of Isoniazid for Pediatric Tuberculosis Treatment

et al. 2020

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Child-appropriate dosage forms are critical in promoting adherence and effective pharmacotherapy in pediatric patients, especially those undergoing long-term treatment in low-resource settings. The present study aimed to develop orodispersible films (ODFs) for isoniazid administration to children exposed to tuberculosis. The ODFs were produced from the aqueous solutions of natural and semi-synthetic polymer blends using electrospinning. The spinning solutions and the resulting fibers were physicochemically characterized, and the disintegration time and isoniazid release from the ODFs were assessed in simulated salivary fluid. The ODFs comprised of nanofibers with adequate thermal stability and possible drug amorphization. Film disintegration occurred instantly upon contact with simulated salivary fluid within less than 15 s, and isoniazid release from the ODFs in the same medium followed after the disintegration profiles, achieving rapid and total drug release within less than 60 s. The ease of administration and favorable drug loading and release properties of the ODFs may provide a dosage form able to facilitate proper adherence to treatment within the pediatric patient population.

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Fast dissolving oral films for drug delivery prepared from chitosan/pullulan electrospinning nanofibers

Cited by 202 publications

References 43 publications

Structural design toward functional materials by electrospinning: A review

Structural design toward functional materials by electrospinning: A review

Ultrathin single and multiple layer electrospun fibrous membranes of polycaprolactone and polysaccharides

Electrospun Orodispersible Films of Isoniazid for Pediatric Tuberculosis Treatment

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