Fast dissolving β-lapachone particles and tablets: an approach using surface adsorption technique

Cunha-Filho, Marcílio; Martínez‐Pacheco, Ramón; Landín, Mariana

doi:10.3109/03639045.2011.630396

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…In the study of Cunha-Filho M.S. 34 , a fast dissolving β-lapachone tablets was prepared to improve the dissolution rate of β-lapachone which lead to a sound result that 90% drug could dissolve at 50 min. In our study, SMMDF had shortened this time to 5 min due to the addition of self-microemulsifying components.…”

Section: Dissolution Of Smmdfmentioning

confidence: 99%

A new self-microemulsifying mouth dissolving film to improve the oral bioavailability of poorly water soluble drugs

Xiao

Yi²,

Liu

2012

Drug Development and Industrial Pharmacy

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A new self-microemulsifying mouth dissolving film (SMMDF) for poorly water-soluble drugs such as indomethacin was developed by incorporating self-microemulsifying components with solid carriers mainly containing microcrystalline cellulose, low-substituted hydroxypropyl cellulose and hypromellose. The uniformity of dosage units of the preparation was acceptable according to the criteria of Chinese Pharmacopoeia 2010. The SMMDF was disintegrated within 20 s after immersion into water, released completely at 5 min in the dissolution medium and achieved microemulsion particle size of 28.81 ± 3.26 nm, which was similar to that of liquid self- microemulsifying drug delivery system (SMEDDS). Solid state characterization of the SMMDF was performed by SEM, DSC and X-ray powder diffraction. Results demonstrated that indomethacin in the SMMDF was in the amorphous state, which might be due to self-microemulsifying ingredients. Pharmacokinetic parameters in rats including T(max), C(max), AUC were similar between the SMMDF and liquid SMEDDS. AUC and C(max) from the SMMDF were significantly higher than those from the common mouth dissolving film or the conventional tablet, and Tmax from SMMDF group was also significantly decreased. These findings suggest that the SMMDF is a new promising dosage form, showing notable characteristics of convenience, quick onset of action and enhanced oral bioavailability of poorly water-soluble drugs.

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Section: Dissolution Of Smmdfmentioning

confidence: 99%

A new self-microemulsifying mouth dissolving film to improve the oral bioavailability of poorly water soluble drugs

Xiao

Yi²,

Liu

2012

Drug Development and Industrial Pharmacy

View full text Add to dashboard Cite

show abstract

Intestinal Permeability of β-Lapachone and Its Cyclodextrin Complexes and Physical Mixtures

Mangas‐Sanjuán

Gutiérrez-Nieto

Echezarreta-López

et al. 2015

Eur J Drug Metab Pharmacokinet

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Fast dissolving β-lapachone particles and tablets: an approach using surface adsorption technique

Abstract: Surface adsorption technique offers a simple way to produce βLAP powder and tablets with improved dissolution rate for oral administration.

Cited by 2 publications

References 17 publications

A new self-microemulsifying mouth dissolving film to improve the oral bioavailability of poorly water soluble drugs

A new self-microemulsifying mouth dissolving film to improve the oral bioavailability of poorly water soluble drugs

Intestinal Permeability of β-Lapachone and Its Cyclodextrin Complexes and Physical Mixtures

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