In this article, an optimization procedure for the placement of integrated circuits (ICs) for reduced radio‐frequency interference (RFI) in mobile devices is presented. The concept of a power conversion factor (PCF) is introduced to quantify the near‐field radiation of ICs based on near‐field measurement techniques. For PCF extraction, equivalent source antennas are designed to represent the radiation chracteristics of ICs. In addition, the concept of a power transfer function (PTF) is also introduced to characterize the near‐field propagation from RFI noise sources to the built‐in antennas in mobile devices. From the combination of the PCFs and the PTFs, a spatial near‐field specification of ICs for reduced RFI is proposed. Based on the proposed specification, the application example of an optimized IC placement in mobile platform design is presented. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:31–37, 2016