By performing two-beam coupling experiments in a liquid crystal light-valve, a large slow-light effect is obtained, with group velocity as slow as a few tenths of mm/s. According to the anisotropic character of the wave-mixing process in liquid crystals, the interactions are accompanied by different behaviors on the different polarization states, with high response to phase changes on the extraordinary wave and the ordinary wave traveling unaffected. Different types of enhanced sensitivity phase detection systems are realized based on the slow-light features of wave-mixing in light-valves, such as common-path polarization interferometers exploiting different polarization states, adaptive holography and nonlinear Sagnac detection.