Fast near infrared light response hydrogel as medical dressing for wound healing

Abstract

Fast‐response smart hydrogels with combination of appropriate mechanical strength, self‐healing and tissue adhesiveness ability, and controllable drug release performance are highly desired as wound dressing practice. Herein, a novel dual‐crosslinking hydrogel with gold nanorods (AuNRs) well dispersed in its polymer network, D‐hydrogel@AuNR, was constructed via ultraviolet light initiated radical copolymerization of acrylamide (AM), isopropylacrylamide (NIPAAM), and dopamine methacrylamide (DMA) in a complex solution of AuNRs and cysteamine‐grafted oxidized sodium alginate (OSA‐SH). The produced D‐hydrogel@AuNR exhibits fast response to the near infrared light (NIR, 808 nm) exposure and a cumulative release level of encapsulated gentamicin sulfate (GS) up to 75% within 60 s laser irradiation. The dual‐crosslinking network that the first MBA crosslinked P(AM‐co‐NIPAAM‐co‐DMA) network and the second imine bonded network makes the tensile stress and tensile strain of D‐hydrogel@AuNR could reach up to 397.0 k Pa and 240%, respectively. Moreover, the received D‐hydrogel@AuNR also exhibits remarkable self‐healing ability and excellent cell affinity and tissue adhesiveness. These desirable properties of D‐hydrogel@AuNR together make it an appropriate candidate for practical wound dressing under different biomedical conditions.

Development of gum odina‐gelatin based antimicrobial loaded biodegradable spongy scaffold: A promising wound care tool

“…Conversely, strong and irreversible adsorption of protein would occur in contact with hydrophobic material for the control experiment. 30,32 The results indicated the blood compatibility nature of biopolymer GO and gelatin based F3B and F3D, which would be safe for use as wound dressing material as stated by Singh and Dhiman. 33…”

“…Swelling study of the experimental scaffolds was performed to evaluate the absorption capacity of wound exudates from the affected site. 18,32 Briefly, pre-weight dry scaffolds (W 0 ) of the small size range (1 × 1 cm) were immersed into different conical flasks containing simulated wound fluid (SWF) (pH 8.0 ± 0.2) 33 and the swollen weights (W t ) were measured at predetermined time intervals. The swelling ratio (%) was calculated by Equation (1).…”

“…Singh and Pal reported the values of water vapor permeability of natural polymer-based sterculia-clpoly(VA) and sterculia-cl-poly(VA-CO-AAM) wound dressing film were 1814.88 ± 249.71 and 3214.14 ± 765.46 mg/day/L respectively, which was almost equivalent to the water vapor permeability value of the experimental scaffold. 32 Thus the significant water vapor permeability of F3D scaffold may promote the angiogenesis that would be helpful for wound healing.…”

Mussel-inspired PDA@PEDOT nanocomposite hydrogel with excellent mechanical strength, self-adhesive, and self-healing properties for a flexible strain sensor

“…The zeta potential is associated with the surface charge of nanoparticles and can be used to determine the stability of colloidal dispersion systems. 36,37 The absolute value of the zeta potential is positively correlated with the mutual repulsion between nanoparticles. As shown in Fig.…”

Fabrication of Multiresponsive Magnetic Nanocomposite Double‐Network Hydrogels for Controlled Release Applications

“…[ 1–4 ] NC hydrogels with different nanomaterials (e.g., carbon‐based nanomaterials, [ 5–8 ] polymer nanoparticles, [ 9 ] inorganic/ceramic nanoparticles, [ 10–12 ] or metal/metal oxide nanoparticles [ 13–15 ] ) present improved mechanical toughness [ 16,17 ] as well as novel performances (e.g., magnetic responsiveness, [ 13,18 ] near‐infrared responsiveness, [ 19–22 ] antimicrobial properties, [ 23,24 ] electricity, [ 25 ] thermal conductivity, [ 26 ] and fluorescence [ 27,28 ] ) for specific applications. Those “smart hydrogels” that respond to internal and external stimuli (e.g., light, [ 29,30 ] pH, [ 31–33 ] temperature, [ 34,35 ] or magnetic field [ 36,37 ] ) have been widely used in tissue engineering, [ 38,39 ] biosensors, [ 40,41 ] and drug delivery. [ 42–44 ]…”