Fast pesticide detection inside microfluidic device with integrated optical pH, oxygen sensors and algal fluorescence

Tahirbegi, Islam Bogachan; Ehgartner, Josef; Sulzer, Philipp; Zieger, Silvia E.; Kasjanow, Alice; Paradiso, Mirco; Štrobl, Martin; Bouwes, Dominique; Mayr, Torsten

doi:10.1016/j.bios.2016.08.014

Cited by 96 publications

(61 citation statements)

References 33 publications

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“…Recently, this method has found application for the integration of pH sensors. 17,45,48 Other methods of droplet generation may be equally suitable for sensor integration and have in fact been used for the production of biosensors. 47 The thickness of the sensor layer can be varied by repeated dispensing onto the same area, or by adjusting the viscosity of the sensor matrix.…”

Section: E Spray-coatingmentioning

confidence: 99%

Integration and application of optical chemical sensors in microbioreactors

et al. 2017

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The quantification of key variables such as oxygen, pH, carbon dioxide, glucose, and temperature provides essential information for biological and biotechnological applications and their development. Microfluidic devices offer an opportunity to accelerate research and development in these areas due to their small scale, and the fine control over the microenvironment, provided that these key variables can be measured. Optical sensors are well-suited for this task. They offer non-invasive and non-destructive monitoring of the mentioned variables, and the establishment of time-course profiles without the need for sampling from the microfluidic devices. They can also be implemented in larger systems, facilitating cross-scale comparison of analytical data. This tutorial review presents an overview of the optical sensors and their technology, with a view to support current and potential new users in microfluidics and biotechnology in the implementation of such sensors. It introduces the benefits and challenges of sensor integration, including, their application for microbioreactors. Sensor formats, integration methods, device bonding options, and monitoring options are explained. Luminescent sensors for oxygen, pH, carbon dioxide, glucose and temperature are showcased. Areas where further development is needed are highlighted with the intent to guide future development efforts towards analytes for which reliable, stable, or easily integrated detection methods are not yet available.

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Section: E Spray-coatingmentioning

confidence: 99%

Integration and application of optical chemical sensors in microbioreactors

et al. 2017

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“…Analytical, laboratory‐based methods, such as gas chromatography, high‐performance liquid chromatography, and mass spectroscopy used to identify and quantify residual pesticide contents are not cost‐effective and portable , . Enzymes, antibodies, cells and DNA‐based biosensors have been industrialised for the detection of pesticide residues with higher sensitivity and accuracy than the conventional methods , . However, accurate monitoring of minute residues of pesticide in a large number of agricultural samples, without the involvement of complex pretreatment procedure is encouraged to revolutionise the modern analytical methods with high selectivity, rapidity and sensitivity.…”

Section: Nanotechnology‐based Sensing Opportunities In Agriculturementioning

confidence: 99%

“…69,70 Enzymes, antibodies, cells and DNA-based biosensors have been industrialised for the detection of pesticide residues with higher sensitivity and accuracy than the conventional methods. 71,72 However, accurate monitoring of minute residues of pesticide in a large number of agricultural samples, without the involvement of complex pretreatment procedure is encouraged to revolutionise the modern analytical methods with high selectivity, rapidity and sensitivity. The detection of organochlorine pesticides, such as aldrin, dieldrin, lindane, and -endosulfan, was reported by using surface-enhanced Raman spectroscopy (SERS) and optimisation of the SERS-sensing substrate.…”

Section: Nanotechnology-based Sensing Opportunities In Agriculturementioning

confidence: 99%

Recent developments in nanotechnology transforming the agricultural sector: a transition replete with opportunities

et al. 2017

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The applications and benefits of nanotechnology in the agricultural sector have attracted considerable attention, particularly in the invention of unique nanopesticides and nanofertilisers. The contemporary developments in nanotechnology are acknowledged and the most significant opportunities awaiting the agriculture sector from the recent scientific and technical literature are addressed. This review discusses the significance of recent trends in nanomaterial-based sensors available for the sustainable management of agricultural soil, as well as the role of nanotechnology in detection and protection against plant pathogens, and for food quality and safety. Novel nanosensors have been reported for primary applications in improving crop practices, food quality, and packaging methods, thus will change the agricultural sector for potentially better and healthier food products. Nanotechnology is well-known to play a significant role in the effective management of phytopathogens, nutrient utilisation, controlled release of pesticides, and fertilisers. Research and scientific gaps to be overcome and fundamental questions have been addressed to fuel active development and application of nanotechnology. Together, nanoscience, nanoengineering, and nanotechnology offer a plethora of opportunities, proving a viable alternative in the agriculture and food processing sector, by providing a novel and advanced solutions. © 2017 Society of Chemical Industry.

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“…Tahirbegi et al. used chip‐integrated pH sensors, along with other sensors, for the in‐situ analysis of pesticides in tap water . Gashti et al.…”

Section: Introductionmentioning

confidence: 99%

Micro free‐flow isoelectric focusing with integrated optical pH sensors

Nagl

2017

Engineering in Life Sciences

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Recently, a new observation method for monitoring of pH gradients in microfluidic free‐flow electrophoresis has emerged. It is based on the use of chip‐integrated fluorescent or luminescent micro sensor layers. These are able to monitor pH gradients in miniaturized separations in real time and spatially resolved; this is particularly useful in isoelectric focusing. Here these multifunctional microdevices that feature continuous separation, monitoring, and in some instances other functionalities, are reviewed. The employed microfabrication procedures to produce these devices are discussed and the different pH sensor matrices that were integrated and their applications in the separation of different types of biomolecules. The procedures for obtaining spatially resolved information about the separated molecules and the pH at the same time and different detection modalities to achieve this such as deep UV fluorescence as well as time‐resolved referenced pH sensing and the integration of a precolumn labeling step into these platforms are also highlighted.

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Fast pesticide detection inside microfluidic device with integrated optical pH, oxygen sensors and algal fluorescence

Cited by 96 publications

References 33 publications

Integration and application of optical chemical sensors in microbioreactors

Integration and application of optical chemical sensors in microbioreactors

Recent developments in nanotechnology transforming the agricultural sector: a transition replete with opportunities

Micro free‐flow isoelectric focusing with integrated optical pH sensors

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