Fast production of high-methoxyl pectin aerogels for enhancing the bioavailability of low-soluble drugs

Tkalec, Gabrijela; Knez, Željko; Novak, Zoran

doi:10.1016/j.supflu.2015.06.009

Cited by 59 publications

(43 citation statements)

References 30 publications

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“…As seen from Fig. 6a, the SSA increases with increasing initial CNC concentration, which is in agreement with reported results, 27 and also with increasing temperature. Figure 6a shows that, of all aerogel samples, the aerogel with the initial CNC concentration of 2.0% has the smallest specific surface area of 203.1 m 2 g −1 at 35 ∘ C, while the one with 3.0% CNC has the highest specific surface area of 387.37 m 2 .g −1 at 40 ∘ C. The SSA of cotton CNCs (dimensions 6 nm × 6 nm × 180 nm) was reported as 419 m 2 g −1 .…”

Section: Residual Solvent Content and Shrinkage Ratio At Different Timessupporting

confidence: 92%

Drying of cellulose nanocrystal gel beads using supercritical carbon dioxide

Hua

Han

et al. 2019

J of Chemical Tech & Biotech

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BACKGROUND The effects of the conditions for the supercritical carbon dioxide (scCO2) drying of cellulose nanocrystal (CNC) wet gel were investigated on the residual solvent content, the shrinkage and the microstructure of the ensuing aerogel. RESULTS The scCO2 drying of CNC wet gel could be divided into a spillage phase and an extraction phase. In the first phase, just a very short time after the beginning of drying, shrinkage occurred and more than half of the solvent was removed. No further shrinkage was observed thereafter, but the solvent continued to be exponentially removed. Increasing pressure, temperature and time were favorable for solvent removal and the reduction of aerogel shrinking. The shrinkage increased the pore size inside the aerogel and made the outer surface of the CNC aerogel much denser than its interior. To preserve the original microstructure of the wet gel, the optimal drying was performed at 11.04 MPa and 40 °C for 120 min. At these conditions, the shrinkage ratio was only inversely proportional to the CNC content in the wet gel. CONCLUSION CNC aerogel was obtained with a shrinkage ratio of 3.1%, a surface area of 387 m2 g−1 and an average pore size of 7.2 nm using 3.0% (w/w) CNC wet gel. © 2019 Society of Chemical Industry

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Section: Residual Solvent Content and Shrinkage Ratio At Different Timessupporting

confidence: 92%

Drying of cellulose nanocrystal gel beads using supercritical carbon dioxide

Hua

Han

et al. 2019

J of Chemical Tech & Biotech

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“…Pectin is a diverse group of anhydrogalacturonic acid polymers with a range of methyl esterification of the carboxy groups (degree of esterification, DE) . The microstructure and final performance of the gels depend on the chemical structure of the polymer sources (mostly DE) and gelation mechanism .…”

Section: Biopolymer Aerogel Systemsmentioning

confidence: 99%

“…Drug administration in biopolymer aerogel carriers can also influence the dissolution of poorly soluble drugs. Tkalec et al . studied the release of nifedipine loaded into pectin aerogels and found that the aerogel carriers significantly improved the dissolution and release of the drug under both simulated gastric fluid conditions (pH 1.2) and under close to physiological conditions: phosphate buffer, pH 6.8.…”

Section: Applicationsmentioning

confidence: 99%

Biopolymer Aerogels and Foams: Chemistry, Properties, and Applications

Zhao

Malfait

Guerrero‐Alburquerque

et al. 2018

Angew Chem Int Ed

590

410

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Biopolymer aerogels were among the first aerogels produced, but only in the last decade has research on biopolymer and biopolymer-composite aerogels become popular, motivated by sustainability arguments, their unique and tunable properties, and ease of functionalization. Biopolymer aerogels and open-cell foams have great potential for classical aerogel applications such as thermal insulation, as well as emerging applications in filtration, oil-water separation, CO capture, catalysis, and medicine. The biopolymer aerogel field today is driven forward by empirical materials discovery at the laboratory scale, but requires a firmer theoretical basis and pilot studies to close the gap to market. This Review includes a database with over 3800 biopolymer aerogel properties, evaluates the state of the biopolymer aerogel field, and critically discusses the scientific, technological, and commercial barriers to the commercialization of these exciting materials.

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“…Pectin ist eine vielfältige Gruppe von Anhydrogalacturonsäure‐Polymeren mit einem Bereich an Methylveresterung von Carboxygruppen (Veresterungsgrad DE) . Die Mikrostruktur und die Eigenschaften der fertigen Gele hängen von der chemischen Struktur der Polymerquellen (hauptsächlich von dem DE) und dem Geliermechanismus ab .…”

Section: Biopolymer‐aerogelsystemeunclassified

“…Der Wirkstofftransport durch Biopolymer‐Aerogel‐Träger kann auch die Auflösung schlecht löslicher Wirkstoffe beeinflussen. Tkalec et al . untersuchten die Freisetzung von auf Pectin‐Aerogele geladenem Nifedipin und fanden, dass die Aerogel‐Träger die Auflösung und die Freisetzung des Wirkstoffs sowohl bei simulierten Magensaft‐Bedingungen (pH 1.2) als auch nahe bei physiologischen Bedingungen in Phosphatpuffer (pH 6.8) verbesserten.…”

Section: Anwendungenunclassified

Biopolymer‐Aerogele und ‐Schäume: Chemie, Eigenschaften und Anwendungen

Zhao

Malfait

Guerrero‐Alburquerque

et al. 2018

Angewandte Chemie

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Biopolymer‐Aerogele gehören zu den ersten Aerogelen, die hergestellt wurden, aber erst im letzten Jahrzehnt kam es zu einer Belebung der Forschung über Biopolymer‐ und Biopolymer‐Verbundstoff‐Aerogele, die durch Fragen der Nachhaltigkeit, einstellbare spezielle Eigenschaften und einfache Funktionalisierung motiviert wird. Biopolymer‐Aerogele und offenzellige Biopolymer‐Schäume haben Potenzial für klassische Aerogel‐Anwendungen wie Wärmedämmung und neue Anwendungen bei der Filtration, Öl‐Wasser‐Trennung, CO2‐Abscheidung, Katalyse und in der Medizin. Das Gebiet der Biopolymer‐Aerogele wird heute von der empirischen Materialentwicklung auf dem Labormaßstab beherrscht und benötigt eine bessere theoretische Grundlage und Test in Pilotanlagen. Unser Aufsatz umfasst eine Datenbank mit über 3800 Biopolymer‐Aerogel‐Eigenschaften, beurteilt den Forschungsstand auf dem Gebiet und diskutiert wissenschaftliche, technologische und wirtschaftliche Hindernisse bei der Kommerzialisierung dieser faszinierenden Materialien.

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Fast production of high-methoxyl pectin aerogels for enhancing the bioavailability of low-soluble drugs

Cited by 59 publications

References 30 publications

Drying of cellulose nanocrystal gel beads using supercritical carbon dioxide

Drying of cellulose nanocrystal gel beads using supercritical carbon dioxide

Biopolymer Aerogels and Foams: Chemistry, Properties, and Applications

Biopolymer‐Aerogele und ‐Schäume: Chemie, Eigenschaften und Anwendungen

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