Fast Progressors in Glaucoma

Jackson, Aidan; Martin, Keith R; Coote, Michael; Medeiros, Felipe A.; Girkin, Christopher A.; Fazio, Massimo A.; Liebmann, Jeffrey M.; Moraes, Carlos Gustavo De; Weinreb, Robert N.; Zangwill, Linda M.; Wu, Zhichao

doi:10.1016/j.ophtha.2023.01.008

Cited by 12 publications

(3 citation statements)

References 41 publications

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“…This study provides important clinical findings for the daily care of patients with EXFG. The cohort demonstrated a rapid average progression of −1.28 dB/y, which is considered fast progression 4,23 . However, there was a significant variation in progression rates among individuals, ranging from −0.1 to 4 dB/y.…”

Section: Discussionmentioning

confidence: 99%

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Risk Factors and Frequency of Examinations for Detecting Visual Field Deterioration in Patients with Newly Diagnosed Exfoliation Glaucoma in Sweden

Ayala

2023

Journal of Glaucoma

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Précis: The study identified risk factors for exfoliation glaucoma and recommended reevaluating target IOP after five visual fields to slow disease progression. Purpose: This study aimed to establish risk factors for exfoliation glaucoma and determine the earliest time points for estimating disease progression. Patients: A total of 96 patients with newly diagnosed exfoliation glaucoma were included. Included patients were required to perform at least seven visual field tests within a three-year period (± three months). All patients were treated at inclusion. Methods: This was a non-randomized, prospective cohort study. The predictors measured included intraocular pressure (IOP), mean deviation (MD), and visual field index (VFI). Progression was assessed using the rate of progression (ROP) based on MD, VFI, and “Guided Progression Analysis” (GPA). Linear or logistic regression models were developed based on the variables studied. An analysis of variance (ANOVA) was used to establish the earliest time point. At the earliest time point, the models were re-tested. The area under the receiver operating characteristic (ROC) curve (AUC) was calculated. Results: The general rate of progression of the cohort was −3.84 (±2.61) dB for the MD values and 9.66 (±6.25) % for the VFI values over three years. The IOP, MD, and VFI values at diagnosis were predictors of progression for both linear and logistic regression. ANOVA and post-hoc Tukey’s test showed significant values at 24 months for MD and VFI. The AUC at 24 months showed significant values for MD and VFI. Conclusions: The predictors studied (IOP, MD, and VFI) showed moderate accuracy at baseline but excellent predictive capacity at 24 months post-diagnosis. Re-evaluating the target IOP at 24 months can effectively slow down disease progression.

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Section: Discussionmentioning

confidence: 99%

“…The cohort demonstrated a rapid average progression of −1.28 dB/y, which is considered fast progression. 4,23 However, there was a significant variation in progression rates among individuals, ranging from −0.1 to 4 dB/y. Therefore, each patient must be assessed individually.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors and Frequency of Examinations for Detecting Visual Field Deterioration in Patients with Newly Diagnosed Exfoliation Glaucoma in Sweden

Ayala

2023

Journal of Glaucoma

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“…Trend-based analysis considered a significantly ( P < 0.05) negative slope of VF MD change (expressed in dB/yr) at two consecutive tests as indicative of VF progression 16 , 17 . The mean value of total deviation values of the 12 central 10° points (MTD 10 ) were evaluated to assess the severity of CVF damage 18 .…”

Section: Methodsmentioning

confidence: 99%

Foveal avascular zone vessel density is associated with visual field progression in early-stage glaucoma eyes with central visual field damage

Yoon,

Kim,

Lee

et al. 2023

Sci Rep

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We investigated the relationship between foveal avascular zone (FAZ)-related parameters, assessed by optical coherence tomography angiography (OCT-A), and visual field (VF) progression in early-stage open-angle glaucoma (OAG) eyes with central visual field (CVF) defects. Early-stage glaucoma eyes [VF mean deviation (MD) ≥ − 6 dB] with CVF defects were included. The rates of longitudinal change in FAZ-related parameters and structural parameters were evaluated and compared between VF progressors and non-progressors, using linear mixed effects models. Cox proportional hazards model and linear regression models were used to identify factors associated with VF progression, the VF MD reduction rate and the change rate of mean total deviation in central 12 VF points (MTD10). A total of 131 eyes were included and VF progression was detected in 32 eyes (24.4%) during 3.45 years of follow-up. The rates of reduction in vessel density in the 300 µm width annular region surrounding the FAZ (FD300) and macular ganglion cell–inner plexiform layer thickness (mGCIPLT) were significantly faster in progressors than in non-progressors. The faster VF MD or MTD10 reduction rates were associated with faster rates of FD300 loss and mGCIPLT reduction. The FD300 reduction rate is significantly associated with VF progression in early-stage OAG eyes with CVF defects. FD300 may be an adjunctive biomarker of VF progression in glaucomatous eyes with CVF defects.

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Glaucoma Progression Detection and Humphrey Visual Field Prediction Using Discriminative and Generative Vision Transformers

Tian,

Zang,

Sharma

et al. 2023

Lecture Notes in Computer Science

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Fast Progressors in Glaucoma

Cited by 12 publications

References 41 publications

Risk Factors and Frequency of Examinations for Detecting Visual Field Deterioration in Patients with Newly Diagnosed Exfoliation Glaucoma in Sweden

Risk Factors and Frequency of Examinations for Detecting Visual Field Deterioration in Patients with Newly Diagnosed Exfoliation Glaucoma in Sweden

Foveal avascular zone vessel density is associated with visual field progression in early-stage glaucoma eyes with central visual field damage

Glaucoma Progression Detection and Humphrey Visual Field Prediction Using Discriminative and Generative Vision Transformers

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