Fast quantification of fluoroquinolones in environmental water samples using molecularly imprinted polymers coupled with internal extractive electrospray ionization mass spectrometry

Kou, Wei; Zhang, Hua; Bibi, Aisha; Ke, Mufang; Han, Jing; Xiong, Jiechao; Su, Rui; Liang, Dapeng

doi:10.1039/c8ra01837e

Cited by 7 publications

(3 citation statements)

References 44 publications

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“…), clinical analysis (including rapid discrimination of tissue samples of human esophageal squamous cell carcinoma, lung cancer, as well as endometriosis foci and blood of ovarian cancer and healthy volunteers based on differences in amino acid and phospholipids metabolism, etc. ), and environmental analysis (including quantification of 1-hydroxypyrene in raw human urine samples, molecular characterization of particulate matters from gasoline cars, and fast quantification of fluoroquinolones in environmental water samples, etc.). A potential issue of this technique is that cells or smaller pieces of tissues may fall off during the analysis and contaminate the instrument.…”

Section: Results and Discussionmentioning

confidence: 99%

Sequential Detection of Lipids, Metabolites, and Proteins in One Tissue for Improved Cancer Differentiation Accuracy

Zhang

Chingin

et al. 2019

Anal. Chem.

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Traditionally, molecular information on metabolites, lipids, and proteins is collected from separate individual tissue samples using different analytical approaches. Herein a novel strategy to minimize the potential material losses and the mismatch between metabolomics, lipidomics, and proteomics data has been demonstrated based on internal extractive electrospray ionization mass spectrometry (iEESI-MS). Sequential detection of lipids, metabolites, and proteins from the same tissue sample was achieved without sample reloading and hardware alteration to MS instrument by sequentially using extraction solutions with different chemical compositions. With respect to the individual compound class analysis, the sensitivity, specificity, and accuracy obtained with the integrative information on metabolites, lipids, and proteins from 57 samples of 13 patients for lung cancer prediction was substantially improved from 54.0%, 51.0%, and 76.0% to 100.0%, respectively. The established method is featured by low sample consumption (ca. 2.0 mg) and easy operation, which is important to minimize systematic errors in precision molecular diagnosis and systems biology studies.

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Section: Results and Discussionmentioning

confidence: 99%

Sequential Detection of Lipids, Metabolites, and Proteins in One Tissue for Improved Cancer Differentiation Accuracy

Zhang

Chingin

et al. 2019

Anal. Chem.

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“…In particular, the internal extraction electrospray ionization (iEESI) technique developed by our group can further obtain the information on internal space rather than only the surfaces of samples when maintaining the above advantages. At present, iEESI-MS has been successfully applied to solve problems associated with food safety, , environmental monitoring, , clinical diagnosis, , and traditional Chinese medicines analysis. , …”

Section: Introductionmentioning

confidence: 99%

Combination of Internal Extractive Electrospray Ionization Mass Spectrometry and Statistical Analysis for High-Throughput Molecular Differentiation of Rehmannia glutinosa Samples

Xu,

Yu,

et al. 2023

J. Am. Soc. Mass Spectrom.

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Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey. is a perennial herb of the Scrophulariaceae family, which has long enjoyed a good reputation in China, and has a wide range of pharmacological effects and clinical applications. The place of origin is an important factor affecting the chemical composition of R. glutinosa, resulting in different pharmacological effects. Herein, internal extractive electrospray ionization mass spectrometry (iEESI-MS) combined with statistical techniques was established for high-throughput molecular differentiation of different R. glutinosa samples. Dried and processed R. glutinosa samples from four different places of origin were analyzed by iEESI-MS with high throughput (>200 peaks) and rapidness (<2 min/sample) without sample pretreatment. Clear separation models created by OPLS-DA were then established for distinguishing the places of origin of dried and processed R. glutinosa by using the obtained MS data. In addition, the molecular differences between the pharmacological effects of dried and processed R. glutinosa were also investigated by OPLS-DA, and 31 different components were screened out. This work provides a promising method for evaluating the quality of traditional Chinese medicines and studying the biochemical mechanism of processing.

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“…A wide variety of procedures and techniques have been applied for the extraction and quantification of FQs in surface water samples. In this sense, the online extraction methodologies [ 11 ], liquid-liquid extraction with subsequent salting-out [ 14 ], solid phase extraction (SPE) by mixed-bed sorbents, C18, or OASIS HLB [ 4 , 15 ], capillary electrophoresis [ 16 ], magnetic mixed hemimicelles [ 17 ], restricted access materials [ 18 ], boron-rich monoliths [ 19 ], Kraft’s lignin [ 20 ], and molecularly imprinted polymers (MIP) can be mentioned [ 21 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

The Ultratrace Determination of Fluoroquinolones in River Water Samples by an Online Solid-Phase Extraction Method Using a Molecularly Imprinted Polymer as a Selective Sorbent

Baeza

Urriza-Arsuaga²,

Navarro-Villoslada³

et al. 2022

Molecules

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Fluoroquinolones (FQs) are broad-spectrum antibiotics widely used to treat animal and human infections. The use of FQs in these activities has increased the presence of antibiotics in wastewater and food, triggering antimicrobial resistance, which has severe consequences for human health. The detection of antibiotics residues in water and food samples has attracted much attention. Herein, we report the development of a highly sensitive online solid-phase extraction methodology based on a selective molecularly imprinted polymer (MIP) and fluorescent detection (HPLC-FLD) for the determination of FQs in water at low ng L−1 level concentration. Under the optimal conditions, good linearity was obtained ranging from 0.7 to 666 ng L−1 for 7 FQs, achieving limits of detection (LOD) in the low ng L−1 level and excellent precision. Recoveries ranged between 54 and 118% (RSD < 17%) for all the FQs tested. The method was applied to determining FQs in river water. These results demonstrated that the developed method is highly sensitive and selective.

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Fast quantification of fluoroquinolones in environmental water samples using molecularly imprinted polymers coupled with internal extractive electrospray ionization mass spectrometry

Abstract: A simple, fast and high-sensitivity method for quantification of fluoroquinolones in environmental water samples using MIPs-iEESI-MS.

Cited by 7 publications

References 44 publications

Sequential Detection of Lipids, Metabolites, and Proteins in One Tissue for Improved Cancer Differentiation Accuracy

Sequential Detection of Lipids, Metabolites, and Proteins in One Tissue for Improved Cancer Differentiation Accuracy

Combination of Internal Extractive Electrospray Ionization Mass Spectrometry and Statistical Analysis for High-Throughput Molecular Differentiation of Rehmannia glutinosa Samples

The Ultratrace Determination of Fluoroquinolones in River Water Samples by an Online Solid-Phase Extraction Method Using a Molecularly Imprinted Polymer as a Selective Sorbent

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