2010
DOI: 10.2174/092986610791760441
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Fast Revelation of the Motif Mode for a Yeast Protein Interaction Network Through Intelligent Agent-Based Distributed Computing

Abstract: In the yeast protein-protein interaction network, motif mode, a collection of motifs of special combinations of protein nodes annotated by the molecular function terms of the Gene Ontology, has revealed differences in the conservation constraints within the same topology. In this study, by employing an intelligent agent-based distributed computing method, we are able to discover motif modes in a fast and adaptive manner. Moreover, by focusing on the highly evolutionarily conserved motif modes belonging to the … Show more

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“…For clear understanding, a network motif is referred to structural network motif throughout this paper, and biological network motifs and structural network motifs have many-to-many relationships. We emphasize that we do not categorize all of the biological network motifs into some classes like 'motif mode' in the study by Lee and Tzou [25], where the number of motif modes reaches up to millions. Instead, we assume that biological network motifs are application dependent, therefore flexibly categorized according to the applications.…”
Section: Methodsmentioning
confidence: 99%
“…For clear understanding, a network motif is referred to structural network motif throughout this paper, and biological network motifs and structural network motifs have many-to-many relationships. We emphasize that we do not categorize all of the biological network motifs into some classes like 'motif mode' in the study by Lee and Tzou [25], where the number of motif modes reaches up to millions. Instead, we assume that biological network motifs are application dependent, therefore flexibly categorized according to the applications.…”
Section: Methodsmentioning
confidence: 99%