In this study, we investigate the nonlinear optical phenomena emerging from the interaction of vortex beams with achiral nanoparticles, leading to the observation of nonlinear circular dichroism in the high-harmonic generation. Despite the achiral symmetry of the nanoparticles, the interplay between the vector properties of the light, the symmetry of the nanoparticles, and the symmetry of the crystalline lattice of the nanoparticle material leads to circular dichroism in the nonlinear regime. We derive a formula that describes the conditions for the appearance of circular dichroism across all possible scenarios, taking into account all the symmetries. We also show that the absolute value of the incident beam's orbital angular momentum does not play a major role. We believe that this work provides important insights that can help in improvement the design process of chiral sensors, making them more versatile and effective.