Fast simultaneous determination of BHA and TBHQ antioxidants in biodiesel by batch injection analysis using pulsed-amperometric detection

Tormin, Thiago F.; Cunha, Rafael R.; Richter, Eduardo M.; Muñoz, Rodrigo A.A.

doi:10.1016/j.talanta.2012.06.024

Cited by 87 publications

(82 citation statements)

References 30 publications

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“…On the other hand, the selection of more positive potentials at the region of plateau of current for all phenolic compounds, which is a common practice when a hydrodynamic method (under stirring or flow rate) with amperometric detection is used, revealed that the use of MWCNT-modified electrodes may not be essential for the determination of HQ, TBHQ, CT, and DP because the gain in sensitivity and linear range is not so significant (10 to 40%). The limit of detection values obtained under both amperometric conditions on the SD-MWCNT-modified GCE were estimated as 0.03 (for DP), 0.17 (for CT and HQ) and 0.33 mmol L À1 (for TBHQ), which are within the values verified by previous works using modified electrodes containing CNTs or composites formed by CNTs and other chemical modifiers applied for DP (0.015-1.76 mmol L À1 ) [37,38,[41][42][43][44][45], CT (0.095-2.0 mmol L À1 ) [39,40,[47][48][49][50], HQ (0.02-2.6 mmol L À1 ) [46][47][48][49][50], and TBHQ (0.067-5.0 mmol L À1 ) [51][52][53][54].…”

Section: Electrochemical Measurementssupporting

confidence: 63%

Multi-walled carbon nanotubes: Size-dependent electrochemistry of phenolic compounds

Cardoso

Montes

Lima

et al. 2015

Electrochimica Acta

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Section: Electrochemical Measurementssupporting

confidence: 63%

Multi-walled carbon nanotubes: Size-dependent electrochemistry of phenolic compounds

Cardoso

Montes

Lima

et al. 2015

Electrochimica Acta

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“…Although conventional instrumental methods such as high-performance liquid chromatography (HPLC) [18], gas chromatography-mass spectrometry (GC-MS) [19] and UV-visible spectrophotometry [20] have been used for the detection of antioxidants, they are always highly technical, cumbersome and time-consuming. Electrochemical sensors 8 offer a timely alternative for BHA and TBHQ detection because of their simplicity, feasibility for miniaturization, rapid and sensitive quantitative analysis [21,22]. Lin has developed a novel electrochemical sensor based on gold nanoparticles (AuNPs/GCE), but the sensor displayed relatively narrow linear ranges of 0.10-1.50 μg mL -1 , 0.20-2.80 μg mL -1 for BHA and TBHQ, respectively [17].…”

Section: Introductionmentioning

confidence: 99%

In situ surface electrochemical co-reduction route towards controllable construction of AuNPs/ERGO electrochemical sensing platform for simultaneous determination of BHA and TBHQ

Yue

Song

Zhu

et al. 2015

Electrochimica Acta

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“…The working electrode as well as the reference and counter electrodes are immersed in a large-volume blank solution. 18 The combination of BIA with pulsed amperometry has been recently proposed for simultaneous determinations in fuel, 19 pharmaceutical and food samples. 20 Pulsed amperometry has also been applied to selective determinations of analytes at electrodes that undergo passivation due to adsorption of electrochemically generated oxidation products.…”

Section: Introductionmentioning

confidence: 99%

Fast determination of naproxen in pharmaceutical formulations by batch injection analysis with pulsed amperometric detection

Stefano¹,

Lima²,

Montes³

et al. 2012

J. Braz. Chem. Soc.

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Um método eletroanalítico original e rápido para a determinação de naproxeno em formulações farmacêuticas usando análise por injeção em batelada (BIA) com detecção amperométrica pulsada é descrito. Eletrodo de carbono vítreo foi usado como eletrodo de trabalho e solução tampão fosfato 0,05 mol L -1 como eletrólito suporte. O método amperométrico envolveu a aplicação contínua de dois pulsos de potencial ao eletrodo de trabalho com intuito de detectar naproxeno pela sua oxidação eletroquímica (+1,5 V por 200 ms) e de limpar a superfície do eletrodo de produtos de adsorção (+1,0 V por 100 ms), evitando contaminação do eletrodo. O método proposto possui várias vantagens para análises de rotina, incluindo: baixo desvio padrão relativo (3,0%, n = 10), elevada frequência analítica (90 h -1 ), exatidão satisfatória (baseado em determinações comparativas por espectrofluorimetria) e baixo limite de detecção (0,3 µmol L -1 ).A novel and fast electroanalytical method for naproxen determination in pharmaceutical formulations using batch injection analysis (BIA) with pulsed amperometric detection is described. Bare glassy carbon electrode was used as working electrode and 0.05 mol L -1 phosphate buffer solution as supporting electrolyte. The amperometric method involved the continuous application of two sequential potential pulses to the working electrode in order to detect naproxen by its electrochemical oxidation (+1.5 V for 200 ms) and to clean the electrode surface from adsorption products (+1.0 V for 100 ms), avoiding electrode contamination. The proposed method has several advantages for routine analysis, including: a low relative standard deviation between injections (3.0%, n = 10), high analytical frequency (90 h -1 ), satisfactory accuracy (based on comparative determinations by spectrofluorimetry) and low limit of detection (0.3 µmol L -1 ).Keywords: batch injection analysis, multiple-pulse amperometry, non-steroidal antiinflammatory drug IntroductionNaproxen, 2-(6-methoxynaphthalen-2-yl) propanoic acid, is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and has been widely used as an over-the-counter analgesic, anti-inflammatory and antipyretic agent. It is also commonly used for the reduction of stiffness caused by conditions including kidney stones, rheumatoid arthritis and other inflammatory rheumatic diseases. 1,2 NSAIDs have been associated with the increasing number of potentially cardiovascular events. However, a recent study classified naproxen as the least harmful NSAID in cardiovascular terms. 3 Different analytical methods have been proposed for the determination of naproxen in pharmaceutical formulations including spectrophotometry (UV region), 4,5 spectrofluorimetry, 6-8 capillary isotachophoresis 9 and high-performance liquid-chromatography (HPLC) coupled with spectrophotometric, 10 amperometric 11 and mass spectrometric detectors. 1 Nevertheless, these analytical methods require expensive equipment and reagents, are time-consuming and often necessitate laborious pre-and pos...

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Fast simultaneous determination of BHA and TBHQ antioxidants in biodiesel by batch injection analysis using pulsed-amperometric detection

Cited by 87 publications

References 30 publications

Multi-walled carbon nanotubes: Size-dependent electrochemistry of phenolic compounds

Multi-walled carbon nanotubes: Size-dependent electrochemistry of phenolic compounds

In situ surface electrochemical co-reduction route towards controllable construction of AuNPs/ERGO electrochemical sensing platform for simultaneous determination of BHA and TBHQ

Fast determination of naproxen in pharmaceutical formulations by batch injection analysis with pulsed amperometric detection

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