Fast synthesis and separation of nanoparticles via in-situ reactive flash nanoprecipitation and pH tuning

Zhu, Zhenbang; Xu, Peng; Fan, Guokang; Liu, Ningning; Xu, Shun; Li, Xianglong; Xue, Huaiguo; Shao, Chuanhua; Guo, Yan‐Lin

doi:10.1016/j.cej.2018.09.103

Cited by 35 publications

(19 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the FNP process requires an environmentally unfriendly organic solvent (usually THF), which needs subsequent purification for organic removal. Recently, J.-D. Marty et al and Zhu et al [39,40] have reported and developed an improved FNP process which retains all of the advantages of conventional FNP while dramatically expanding the types of NPs that can be synthesized in one step to include metal composite NPs in aqueous environment without complicated post-processing. This improved FNP technology has been applied to the successful synthesis of GdPO 4 -based NPs and chitosan/PbSO 4 NPs.…”

Section: Introductionmentioning

confidence: 99%

Scalable Yielding of Highly Stable Polyelectrolyte‐Coated Copper Sulfide Nanoparticles by Flash Nanoprecipitation for Photothermal‐Chemotherapeutics

Jia

Yan

Kayitmazer

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

Photothermal‐chemotherapeutic nanoparticles (NPs) are attracting increasing attention and becoming more widely used for cancer therapy in the clinic due to their noninvasiveness, notable tissue penetration abilities, and low systemic adverse effects. However, functional ligands are conventionally modified onto photothermal NPs to well stabilize the inorganic particles suffering from complex chemical modifications, low productivity, and batch‐to‐batch inconsistencies, and thus significantly restricting their clinical applications. Herein, flash nanoprecipitation (FNP) is taken advantage of to afford rapid and uniform mixing for generating local supersaturated CuS clusters for small and highly stable CuS NPs effectively stabilized by polyacrylic acid through a continuous strategy. It greatly reduces the complexity for CuS NPs synthesis and functionalization in a facile intensified mixing process. These as‐synthesized particles are high‐drug loading, scalable, and most importantly, it is easy to control their sizes and charges through external conditions. Toxicity and tumor inhibition experiments confirm the high cell toxicity and good suppression of tumor growth under near‐infrared irradiation indicating a promising prospect of FNP in the large‐scale and continuous yielding of highly stable and high‐performing photothermal‐chemotherapeutic NPs for cancer therapy.

show abstract

Section: Introductionmentioning

confidence: 99%

Scalable Yielding of Highly Stable Polyelectrolyte‐Coated Copper Sulfide Nanoparticles by Flash Nanoprecipitation for Photothermal‐Chemotherapeutics

Jia

Yan

Kayitmazer

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

“…In total, 5.0 ml of each solution was then loaded into an individual gas-tight plastic syringe connected with an individual inlet of the CIJ-D mixer. The mixer used in this study was the same as the one used in our previous RFNP work [ 31 ]. The two syringes were propelled at the same speed and solutions were injected into the mixer at the same flow rate of about 1.0 ml/s.…”

Section: Methodsmentioning

confidence: 99%

“…Zhu et al combined the FNP technique with an in situ chemical reaction and proposed the reactive FNP (RFNP) [ 29 ], and the competitions between turbulence mixing and chemical reactions were investigated [ 30 ]. Zhu et al further employed the CIJ-D mixer into the RFNP and realized a fast generation and separation of nanoparticles, which was promising for large-scale industrial production [ 31 ]. Since the fluids were mixed evenly in the chamber within tens of microseconds, the succeeding chemical reaction and phase separation (i.e., solid nanoparticles form in an aqueous medium) can start evenly and instantly.…”

Section: Introductionmentioning

confidence: 99%

Preparation of bioactive glass nanoparticles with highly and evenly doped calcium ions by reactive flash nanoprecipitation

et al. 2021

J Mater Sci: Mater Med

Self Cite

View full text Add to dashboard Cite

Nanoscale bioactive glass particles have greater bioactivity than microscale bioactive glass particles, due to their high-specific surface area and fast ion release rate in body fluid. However, preparation of bioactive glass nanoparticles (BGNPs) is difficult since calcium is not easy to be highly doped into the forming silica atom network, leading to an uneven distribution and a low content of calcium. In addition, BGNPs are usually prepared in a dilute solution to avoid agglomeration of the nanoparticles, which decreases the production efficiency and increases the cost. In this work, BGNPs are prepared by a method of the reactive flash nanoprecipitation (RFNP) as well as a traditional sol–gel method. The results indicate that the BGNPs by the RFNP present a smaller size, narrower size distribution, more uniform composition, and better bioactivity than those by the traditional sol–gel method. The obtained BGNPs have uniform compositions close to the feed values. The high and even doping of calcium in the BGNPs is achieved. This successful doping of calcium into nanoparticles by the RFNP demonstrates a promising way to effectively generate high-quality BGNPs for bone repairs.

show abstract

“…Herein, we report a simple, rapid and scalable method to synthesize ultra-high SSA MSNs with wellde ned mesoporous spherical structure and large pore volume by using a two-stream con ned jet impingement continuous microchannel reactor (CJI-CMR) [22][23][24] . Taken together with soft-templating CTAB, CJI-CMR was used for mass transfer intensi cation in reactors during hydrolysis/condensation of TEOS in ethanol/NH 4 OH solution and vigorous magnetic stirring were utilized in a one-pot synthesis process of novel MSNs at room conditions.…”

Section: Introductionmentioning

confidence: 99%

High-quality mesoporous SiO2 nanospheres via a confined jet impingement continuous microchannel reactor

Chen

et al. 2021

Preprint

View full text Add to dashboard Cite

High surface area mesoporous silica (SiO2) nanospheres has been considered an ideal material for the catalytic, adsorption and drug delivery. However, synthesis of ultra-high specific surface area mesoporous silica nanoparticles with well-defined sphere structure and small particle size (< 200 nm) is still challenging. Here, a two-stream confined jet impingement continuous microchannel reactor is proposed to produce novel mesoporous silica nanospheres (MSNs) with ultra-high specific surface area (SSA) and abundant worm-like meso-porosity. The as-obtained MSNs with worm-like mesoporous structure were produced with average particle diameter of 142 ~ 207 nm, high SSA of 1347 ~ 1854 m2/g, total pore volume of 0.86 ~ 1.23 cm3/g and pore diameter of 2.6 ~ 3.3nm. Moreover, the shear force field in the microchannel reactor on the mesoscopic structure of MSNs was simulated by mesoscopic kinetics. Additionally, MSNs was used as the silicon source to synthesize lithium silicate (Li4SiO4), which enhanced carbon dioxide (CO2) adsorption of 27.18 wt% at 650 ℃.

show abstract

Fast synthesis and separation of nanoparticles via in-situ reactive flash nanoprecipitation and pH tuning

Cited by 35 publications

References 58 publications

Scalable Yielding of Highly Stable Polyelectrolyte‐Coated Copper Sulfide Nanoparticles by Flash Nanoprecipitation for Photothermal‐Chemotherapeutics

Scalable Yielding of Highly Stable Polyelectrolyte‐Coated Copper Sulfide Nanoparticles by Flash Nanoprecipitation for Photothermal‐Chemotherapeutics

Preparation of bioactive glass nanoparticles with highly and evenly doped calcium ions by reactive flash nanoprecipitation

High-quality mesoporous SiO2 nanospheres via a confined jet impingement continuous microchannel reactor

Contact Info

Product

Resources

About