Fast-track rehabilitation for acute cholecystitis: intermediate outcomes of prospective randomized trial

Enhanced Recovery After Surgery Guidelines and Hospital Length of Stay, Readmission, Complications, and Mortality

“…The search strategy yielded 12 047 unique references, of which 1493 were reviewed in full-text, 495 were included in the overall systematic review (eFigure in Supplement 1 ) and 74 RCTs 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 ...…”

“…The search strategy yielded 12 047 unique references, of which 1493 were reviewed in full-text, 495 were included in the overall systematic review (eFigure in Supplement 1) and 74 RCTs were included in the meta-analysis. The characteristics of each individual study are included in eTable 1 in Supplement 1.…”

“…Most of the 74 studies examined the outcomes of ERAS in patients undergoing gastrointestinal surgery (32 [43.2%]) and gynecological surgical procedures (11 [14.9%]), with only 1 (1.4%) in cardiac surgery, and 2 (2.7%) in urology . Most of the 74 studies evaluated the outcomes of ERAS guidelines (37 [50.0%]), whereas 23 (31.1%) evaluated enhanced recovery protocols, 13 (17.6%) evaluated fast-track protocols, and 1 (1.4%) evaluated other types of protocols or pathways based on ERAS principles . The mean (SD) number of ERAS elements included in the interventions (ERAS, enhanced protocols, fast-track, other) was 11.1 (3.0) elements of a possible 16.…”

“…Most of the 74 studies examined the outcomes of ERAS in patients undergoing gastrointestinal surgery (32 [43.2%]) 39 , 40 , 45 , 47 , 50 , 51 , 53 , 54 , 56 , 58 , 59 , 60 , 73 , 74 , 77 , 79 , 80 , 83 , 87 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 100 , 102 , 103 , 105 , 112 , 114 and gynecological surgical procedures (11 [14.9%]), 41 , 43 , 49 , 52 , 65 , 89 , 90 , 110 , 111 , 115 with only 1 (1.4%) in cardiac surgery, 68 and 2 (2.7%) in urology. 44 , 106 Most of the 74 studies evaluated the outcomes of ERAS guidelines (37 [50.0%]), 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 48 , 52 , 53 , 54 ...…”

“…There were 19 of 74 studies that reported 30-day postoperative mortality, with a pooled risk of 0.95 (95% CI, 0.48-1.88) with no heterogeneity between estimates ( I 2 = 0%; P = .89). 40 , 44 , 50 , 53 , 54 , 57 , 69 , 70 , 77 , 78 , 87 , 89 , 92 , 93 , 95 , 96 , 97 , 98 , 107 Because many studies reported estimates of 0 mortality, a continuity correction was applied to calculate RRs. 118 Publication bias was not significant.…”