Fast Transport of Materials in Mammalian Nerve Fibers

Ochs, Sidney

doi:10.1126/science.176.4032.252

Cited by 371 publications

(127 citation statements)

References 68 publications

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“…The conclusion about the f 0 (1370) agrees with results of the work of the Crystal Barrel Collaboration [33] where the f 0 (1370) is identified as the ηη resonance in the π 0 ηη final state of thepp annihilation at rest. This also explains well why one did not find this state considering only the ππ scattering process [4]. The conclusion about the f 0 (1710) is consistent with the experimental fact that this state is observed in γγ → K S K S [34] but it is not observed in…”

Section: Discussion Of the Results And Conclusionsupporting

confidence: 77%

“…As for the meson parameters, let us mention the widely discussed f 0 (500)/σ meson (formerly f 0 (600)), f 0 (980), and f 0 (1500). A doubtful meson existence can be demonstrated on the case of the f 0 (1370) state which is apparently required by a bulk of data [3], but in some analyses of only the ππ scattering no evidence for its existence was found [4]. We have shown that the existence of the f 0 (1370) does not contradict the data on ππ → ππ , KK, ηη, ηη ′ [2].…”

Section: Introductionmentioning

confidence: 64%

See 1 more Smart Citation

Parameters of scalar resonances from the combined analysis of data on processesππ→ππ,KK¯
Surovtsev
¹
,
Bydžovský
²
,
Kamiński
³

et al. 2014
Phys. Rev. D
8
4
11
0
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A combined analysis of data on the isoscalar S-wave processes ππ → ππ, KK, ηη and on decays J/ψ → φππ, φKK from the DM2, Mark III and BES II Collaborations is performed to study f0 mesons. The method of analysis is based on analyticity and unitarity and uses an uniformization procedure. In the analysis limited only to the multichannel ππ-scattering data, two possible sets of parameters of the f0(500) were found: In both cases the mass was about 700 MeV but the total width was either about 680 or 1040 MeV. The extension of the analysis using only the DM2 and Mark III data on the J/ψ decays does not allow us to choose between these sets. However, the data from BES II on the di-pion mass distribution in the decay J/ψ → φπ + π − clearly prefer the wider f0(500) state. Spectroscopic implications from the results of the analysis are also discussed.

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Section: Discussion Of the Results And Conclusionsupporting

confidence: 77%

Section: Introductionmentioning

confidence: 64%

Parameters of scalar resonances from the combined analysis of data on processesππ→ππ,KK¯
Surovtsev
¹
,
Bydžovský
²
,
Kamiński
³

et al. 2014
Phys. Rev. D
8
4
11
0
View full text Add to dashboard Cite

show abstract

“…We presume that the virus is transported across the nerve cell without replicating in the cell soma. Similar fast anterograde transport mechanisms have been widely reported for other cellular components (Couraud & DiGiamberardino, 1980;Gilbert et al, 1985;Lorenz & Willard, 1978;Lubinska & Niemierko, 1971 ;Ochs, 1972). The mean velocity of rabies virus fast transport was estimated to be in the range of 100 to 400 mm per day which is in accordance with the velocities (360 mm/day) reported for rat sensory neurons (Aquino et al, 1987).…”

Section: Retrograde and Anterograde Transport Of Rabies Virus In A Musupporting

confidence: 76%

The Anterograde Transport of Rabies Virus in Rat Sensory Dorsal Root Ganglia Neurons

Tsiang¹,

Lycke²,

Ceccaldi³

et al. 1989

Journal of General Virology

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SUMMARYWe have previously described the capacity of neurites extending from cultured rat sensory dorsal root ganglia (DRG) neurons to transport rabies virus through axoplasm in the retrograde direction. Here we report the infection of cultured neurons derived from the DRG and the subsequent anterograde transport of rabies virus from the infected cell somas through the extending neurites to its release into the culture supernatant. Viral transport was monitored by titration of the virus yield in the external compartment. Both early and late transport mechanisms of rabies virions were identified. The first one occurred a few hours post-infection and was undetectable 6 h later, before the initiation of viral replication. The velocity of this first wave of infective virions was in the range of 100 to 400 mm/day. The early viral transport was probably the result of a direct translocation of infective virions from the somatic site of entry to the neuritic extensions and subsequent release into the culture medium without replication in the cellular perikaryon. The second virus transport peak was detected 48 h post-infection. In this case, the virions detected in the neuritic compartment were presumably the progeny of the inoculated virus which had replicated in the perikaryon before the viral transport occurs. Using a four-compartment culture device we were able to demonstrate, simultaneously, retrograde and anterograde transport of the virus. The presence of antirabies serum in contact with the exposed neurites did not inhibit either the retrograde or the anterograde transport mechanisms. The viral release from the neuritic extensions after the fast anterograde transport was evaluated to be in the range of 150 to 300 infectious virions per bundle of neurites per day.

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“…Axonal transport in different systems was reported to be between 1 and 3 m/s on average, sometimes with maximal velocities of up to 5 m/s (Allen et al, 1982;Kreis et al, 1989;Bloom et al, 1993;Lochner et al, 1998;Nakata et al, 1998;Zakharenko and Popov, 1998;Bridgman, 1999). The velocity measured for APP-YFP in our system is in the range of the fast component of fast axonal transport in mammals in vivo, which has been calculated to have a velocity of 410 mm/d (Ochs, 1972), corresponding to 4.7 m/s.…”

Section: Discussionmentioning

confidence: 79%

Axonal Membrane Proteins Are Transported in Distinct Carriers: A Two-Color Video Microscopy Study in Cultured Hippocampal Neurons

Kaether

Skehel²,

Dotti

2000

MBoC

255

227

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Neurons transport newly synthesized membrane proteins along axons by microtubule-mediated fast axonal transport. Membrane proteins destined for different axonal subdomains are thought to be transported in different transport carriers. To analyze this differential transport in living neurons, we tagged the amyloid precursor protein (APP) and synaptophysin (p38) with green fluorescent protein (GFP) variants. The resulting fusion proteins, APP-yellow fluorescent protein (YFP), p38-enhanced GFP, and p38-enhanced cyan fluorescent protein, were expressed in hippocampal neurons, and the cells were imaged by video microscopy. APP-YFP was transported in elongated tubules that moved extremely fast (on average 4.5 m/s) and over long distances. In contrast, p38-enhanced GFP-transporting structures were more vesicular and moved four times slower (0.9 m/s) and over shorter distances only. Two-color video microscopy showed that the two proteins were sorted to different carriers that moved with different characteristics along axons of doubly transfected neurons. Antisense treatment using oligonucleotides against the kinesin heavy chain slowed down the long, continuous movement of APP-YFP tubules and increased frequency of directional changes. These results demonstrate for the first time directly the sorting and transport of two axonal membrane proteins into different carriers. Moreover, the extremely fast-moving tubules represent a previously unidentified type of axonal carrier.

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Fast Transport of Materials in Mammalian Nerve Fibers

Cited by 371 publications

References 68 publications

Parameters of scalar resonances from the combined analysis of data on processesππ→ππ,KK¯
Surovtsev
¹
,
Bydžovský
²
,
Kamiński
³

et al. 2014
Phys. Rev. D
8
4
11
0
View full text Add to dashboard Cite

Parameters of scalar resonances from the combined analysis of data on processesππ→ππ,KK¯
Surovtsev
¹
,
Bydžovský
²
,
Kamiński
³

et al. 2014
Phys. Rev. D
8
4
11
0
View full text Add to dashboard Cite

The Anterograde Transport of Rabies Virus in Rat Sensory Dorsal Root Ganglia Neurons

Axonal Membrane Proteins Are Transported in Distinct Carriers: A Two-Color Video Microscopy Study in Cultured Hippocampal Neurons

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Fast Transport of Materials in Mammalian Nerve Fibers

Cited by 371 publications

References 68 publications

Parameters of scalar resonances from the combined analysis of data on processesππ→ππ,KK¯Surovtsev1, Bydžovský2, Kamiński3 et al. 2014Phys. Rev. D84110View full textAdd to dashboardCite

Parameters of scalar resonances from the combined analysis of data on processesππ→ππ,KK¯Surovtsev1, Bydžovský2, Kamiński3 et al. 2014Phys. Rev. D84110View full textAdd to dashboardCite

The Anterograde Transport of Rabies Virus in Rat Sensory Dorsal Root Ganglia Neurons

Axonal Membrane Proteins Are Transported in Distinct Carriers: A Two-Color Video Microscopy Study in Cultured Hippocampal Neurons

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Product

Resources

About

Parameters of scalar resonances from the combined analysis of data on processesππ→ππ,KK¯
Surovtsev
¹
,
Bydžovský
²
,
Kamiński
³

et al. 2014
Phys. Rev. D
8
4
11
0
View full text Add to dashboard Cite

Parameters of scalar resonances from the combined analysis of data on processesππ→ππ,KK¯
Surovtsev
¹
,
Bydžovský
²
,
Kamiński
³

et al. 2014
Phys. Rev. D
8
4
11
0
View full text Add to dashboard Cite