Faster, better, and cheaper: harnessing microfluidics and mass spectrometry for biotechnology

Abstract

High-throughput screening technologies are widely used for elucidating biological activities. These typically require trade-offs in assay specificity and sensitivity to achieve higher throughput. Microfluidic approaches enable rapid manipulation of small...

Advances in integrated digital microfluidic platforms for point-of-care diagnosis: a review

“…168 Detailed reviews on sample preparation in DMF devices for MALID-MS can be found elsewhere. 8,[168][169][170][171] In this section, we summarize efforts on integrating nESI/MALDI in DMF platforms which aims at transferring target samples directly into mass spectrometers for further processing.…”

A Review of Optical Imaging Technologies for Microfluidics

“…In order to achieve sample observation and detection and accurate quantitative analysis, detection technology will play an increasingly important role. At present, a variety of detection technologies have been applied to microfluidic chips, including electrochemistry [21][22][23], capillary electrophoresis [24,25], mass spectrometry [26][27][28], nuclear magnetic resonance spectroscopy [29][30][31][32][33][34], and optical detection [35][36][37]. Because of the particularity of the microfluidic chip, when considering the detection element, the sensitivity and dimensional ductility of the element must be considered.…”

Multifunctional microfluidic chips for the single particle inductively coupled plasma mass spectrometry analysis of inorganic nanoparticles

“…In these efforts, microfluidic devices have been interfaced to ICP-MS with the focus on applications mainly in the fields of elemental speciation and biological sample analysis, including single cells and lyzed cell populations. 8,9 Researchers at Hull University (England) were among the first ones to describe such interfacing. As early as in 2002, they developed microchip devices for the speciation of Cr(III), Cr(VI) and Cu(II) based on electrophoretic separation with ICP-MS detection.…”

“…In these efforts, microfluidic devices have been interfaced to ICP-MS with the focus on applications mainly in the fields of elemental speciation and biological sample analysis, including single cells and lyzed cell populations. 8,9…”