“…However, the fastest HPC simulation workflows (e.g., de la Asunción et al, 2013;Oishi et al, 2015;Macías et al, 2017;Musa et al, 2018) still require typically 10-60 min to simulate tsunami inundation at a scale of tens of meters, rendering them unsuitable for extensive PTRA studies with up to millions of scenarios (Basili et al, 2021). To overcome this "challenge of scales", modeling approximations are presently necessary for PTHA feasibility and can either involve 1) largely reducing the number of inundation scenarios (e.g., González et al, 2009;Lorito et al, 2015;Volpe et al, 2019;Williamson et al, 2020), 2) use of approximate models or statistics such as amplification factors (e.g., Løvholt et al, 2012;Kriebel et al, 2017;Gailler et al, 2018;Glimsdal et al, 2019), or 3) machine learning-based tsunami emulators (e.g., Sarri et al, 2012;Salmanidou et al, 2017;Giles et al, 2020).…”