Fasting-induced increases of arcuate NPY mRNA and plasma corticosterone are blunted in the rat experienced neonatal maternal separation

Depressive behaviors and decreased expression of serotonin reuptake transporter in rats that experienced neonatal maternal separation

“…Thus, decreased 5-HT contents in the hippocampus of MS rats may implicate dysfunctions in their HPA axis activity. Indeed, we previously showed that CRH mRNA expression responding to cold stress (Kim et al, 2005a) and corticosterone increase responding to food deprivation (Kim et al, 2005b) were blunted in our animal model of maternal separation. It was also reported that rats experienced neonatal maternal separation showed anxious behavior with blunted ACTH response to stress, and their hippocampal 5-HTergic activity responding to stress was modulated (Daniels et al, 2004).…”

“…In our previous study, MS rats were slightly heavier than NH rats at PND 22 and 29, and the weight differences between the NH and the MS groups became non-significant statistically from PND 36 (Kim et al, 2005b). Daily chow intake of MS rats used in our previous study did not differ from NH rats (unpublished observation).…”

“…We previously reported that repeated maternal separation during the first 2 weeks of life in rats blunted mRNA expression of corticotropin-releasing hormone (CRH) responding to cold stress (Kim et al, 2005a) and the increase of plasma corticosterone responding to food deprivation, a stressful episode (Kim et al, 2005b). In this study, the hippocampal 5-HT contents and the raphe expression of 5-HTT mRNA were examined in our maternal separation model parallel with behavioral assessments for depression and anxiety.…”

The arcuate NPY, POMC, and CART expressions responding to food deprivation are exaggerated in young female rats that experienced neonatal maternal separation

“…3 h of daily MS during the first two weeks of birth, have reported that weight gain of MS females does not differ from NH females until 2 months of age, except a transient increase shortly after the separation period (Kalinichev et al, 2002;Slotten et al, 2006;Maniam and Morris, 2010). It appears that neonatal maternal separation acutely, but not permanently, affects body weight gain of the offspring as long as the littermates are housed in group with ad libitum access to food (Mclntosh et al, 1999;Iwasaki et al, 2000;Kalinichev et al, 2002;Kim et al, 2005;Slotten et al, 2006;Maniam and Morris, 2010).…”

Sustained hyperphagia in adolescent rats that experienced neonatal maternal separation

“…22 Rats that experienced neonatal MS also showed depression-and anxiety-like behaviors with alterations in the brain serotonergic system. 23 Patients with eating disorders often exhibit symptoms of depression and/or anxiety, and serotonergic dysfunctions have been suggested to be implicated in the pathophysiology of eating disorders.…”