2022
DOI: 10.1016/j.cmet.2022.04.012
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Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling

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Cited by 38 publications
(33 citation statements)
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“…During fasting or KD, muscle stem cells (MuSCs) are converted to highly resilient deep quiescence where they could obtain ameliorative survival under diverse cellular stress. 311 However, patients ingesting dietary proteins mainly at breakfast were found to have higher muscle function than those ingesting dietary proteins at dinner. In the early active phase, protein intake, especially BCAA supplementation, promotes skeletal muscle hypertrophy in a muscle-clock-reliable manner.…”
Section: Dietary Intervention In Tissue Health and Diseasementioning
confidence: 99%
“…During fasting or KD, muscle stem cells (MuSCs) are converted to highly resilient deep quiescence where they could obtain ameliorative survival under diverse cellular stress. 311 However, patients ingesting dietary proteins mainly at breakfast were found to have higher muscle function than those ingesting dietary proteins at dinner. In the early active phase, protein intake, especially BCAA supplementation, promotes skeletal muscle hypertrophy in a muscle-clock-reliable manner.…”
Section: Dietary Intervention In Tissue Health and Diseasementioning
confidence: 99%
“…The importance of BHB in mediating the salutary actions of fasting and CR has been demonstrated in mammals and the multiple organs therein [3] . BHB generally plays an adaptive role in the heart, not only as an alternative fuel during heart failure but also as a signaling molecule that directly inhibits HDAC1 and promotes downstream cell protective mechanisms, including upregulation of thioredoxin 1 and suppression of mTOR [7][8][9][10] .…”
mentioning
confidence: 99%
“…In a recent paper published in Cell Metabolism , Benjamin et al demonstrated that fasting delays muscle regeneration acutely but promotes a state of deep quiescence (DQ) characterized by downregulation of cell proliferation genes and upregulation of genes involved in stemness in muscle stem cells (MuSCs) [ 4 ] . MuSCs with DQ are highly stress-resistant and exhibit improved survival during stress.…”
mentioning
confidence: 99%
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