Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape

Salvadori, Giulia; Zanardi, Federica; Iannelli, Fabio; Lobefaro, Riccardo; Vernieri, Claudio; Longo, Valter D.

doi:10.1016/j.cmet.2021.10.008

Cited by 93 publications

(72 citation statements)

References 47 publications

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“…A clinical trial with 131 patients with HER2-negative breast cancer demonstrated that a FMD adhered to for 3 days prior to chemotherapy administration remained safe, effective, and lowered DNA damage in T cells as one metric of enhanced sensitivity to chemotherapeutic response [ 211 ]. Preclinical work has demonstrated the FMD to be effective against TNBC progression in combination with PI3K/AKT/mTOR inhibitors by potentiating kinase inhibitor response and reducing hyperglycemia, often a treatment-induced side effect [ 212 ]. Promising results from a clinical trial in which a majority of participants had breast cancer show that the FMD increases total and activated intratumor CD8 + T cells while decreasing circulating populations of immunosuppressive cells [ 252 ].…”

Section: Dietary Interventions To Intercept Obesity-mediated Exacerba...mentioning

confidence: 99%

The obesity-breast cancer link: a multidisciplinary perspective

Devericks

Carson

McCullough

et al. 2022

Cancer Metastasis Rev

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Obesity, exceptionally prevalent in the USA, promotes the incidence and progression of numerous cancer types including breast cancer. Complex, interacting metabolic and immune dysregulation marks the development of both breast cancer and obesity. Obesity promotes chronic low-grade inflammation, particularly in white adipose tissue, which drives immune dysfunction marked by increased pro-inflammatory cytokine production, alternative macrophage activation, and reduced T cell function. Breast tissue is predominantly composed of white adipose, and developing breast cancer readily and directly interacts with cells and signals from adipose remodeled by obesity. This review discusses the biological mechanisms through which obesity promotes breast cancer, the role of obesity in breast cancer health disparities, and dietary interventions to mitigate the adverse effects of obesity on breast cancer. We detail the intersection of obesity and breast cancer, with an emphasis on the shared and unique patterns of immune dysregulation in these disease processes. We have highlighted key areas of breast cancer biology exacerbated by obesity, including incidence, progression, and therapeutic response. We posit that interception of obesity-driven breast cancer will require interventions that limit protumor signaling from obese adipose tissue and that consider genetic, structural, and social determinants of the obesity–breast cancer link. Finally, we detail the evidence for various dietary interventions to offset obesity effects in clinical and preclinical studies of breast cancer. In light of the strong associations between obesity and breast cancer and the rising rates of obesity in many parts of the world, the development of effective, safe, well-tolerated, and equitable interventions to limit the burden of obesity on breast cancer are urgently needed.

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Section: Dietary Interventions To Intercept Obesity-mediated Exacerba...mentioning

confidence: 99%

The obesity-breast cancer link: a multidisciplinary perspective

Devericks

Carson

McCullough

et al. 2022

Cancer Metastasis Rev

View full text Add to dashboard Cite

show abstract

“…A study in a human xenograft prostate cancer model, an IF regimen comprised of 2 separate 24-h fasting periods per week exhibited similar trends toward delayed tumor growth and improved survival compared to an iso-caloric control group [ 120 ]. When combined with a fasting-mimicking diet, IF blocks TNBC and cancer stem cell escape in mice [ 121 ]. Interestingly, several short-term randomized clinical trials have indicated promising effects of alternate day fasting or a 5:2 diet in improving some cancer risk factors, including decreased fasting glucose, insulin, and leptin levels and increased adiponectin [ 22 ].…”

Section: Health Benefits Of Time-restricted Eatingmentioning

confidence: 99%

Obesity, cancer risk, and time-restricted eating

Das

Webster

2022

Cancer Metastasis Rev

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Obesity and the associated metabolic syndrome is considered a pandemic whose prevalence is steadily increasing in many countries worldwide. It is a complex, dynamic, and multifactorial disorder that presages the development of several metabolic, cardiovascular, and neurodegenerative diseases, and increases the risk of cancer. In patients with newly diagnosed cancer, obesity worsens prognosis, increasing the risk of recurrence and decreasing survival. The multiple negative effects of obesity on cancer outcomes are substantial, and of great clinical importance. Strategies for weight control have potential utility for both prevention efforts and enhancing cancer outcomes. Presently, time-restricted eating (TRE) is a popular dietary intervention that involves limiting the consumption of calories to a specific window of time without any proscribed caloric restriction or alteration in dietary composition. As such, TRE is a sustainable long-term behavioral modification, when compared to other dietary interventions, and has shown many health benefits in animals and humans. The preliminary data regarding the effects of time-restricted feeding on cancer development and growth in animal models are promising but studies in humans are lacking. Interestingly, several short-term randomized clinical trials of TRE have shown favorable effects to reduce cancer risk factors; however, long-term trials of TRE have yet to investigate reductions in cancer incidence or outcomes in the general population. Few studies have been conducted in cancer populations, but a number are underway to examine the effect of TRE on cancer biology and recurrence. Given the simplicity, feasibility, and favorable metabolic improvements elicited by TRE in obese men and women, TRE may be useful in obese cancer patients and cancer survivors; however, the clinical implementation of TRE in the cancer setting will require greater in-depth investigation.

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“…In contrast, in fed mice, similar doses induce apoptotic cell death in most of the SC compartments [ 89 ]. In CSCs derived from TNBC, FMD inhibits the PKA pathway, whereas in non-CSCs it mainly activates PI3K-AKT, mTOR, and CDK4/6, and thus can be selectively targeted to arrest tumor growth [ 192 ].…”

Section: Effects Of Specific Diets On Stem Cellsmentioning

confidence: 99%

Role of Diet in Stem and Cancer Stem Cells

Puca

Fedele

Rasio

et al. 2022

IJMS

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Diet and lifestyle factors greatly affect health and susceptibility to diseases, including cancer. Stem cells’ functions, including their ability to divide asymmetrically, set the rules for tissue homeostasis, contribute to health maintenance, and represent the entry point of cancer occurrence. Stem cell properties result from the complex integration of intrinsic, extrinsic, and systemic factors. In this context, diet-induced metabolic changes can have a profound impact on stem cell fate determination, lineage specification and differentiation. The purpose of this review is to provide a comprehensive description of the multiple “non-metabolic” effects of diet on stem cell functions, including little-known effects such as those on liquid-liquid phase separation and on non-random chromosome segregation (asymmetric division). A deep understanding of the specific dietetic requirements of normal and cancer stem cells may pave the way for the development of nutrition-based targeted therapeutic approaches to improve regenerative and anticancer therapies.

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Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape

Cited by 93 publications

References 47 publications

The obesity-breast cancer link: a multidisciplinary perspective

The obesity-breast cancer link: a multidisciplinary perspective

Obesity, cancer risk, and time-restricted eating

Role of Diet in Stem and Cancer Stem Cells

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