Fasting oxyntomodulin, glicentin, and gastric inhibitory polypeptide levels are associated with activation of reward‐ and attention‐related brain centres in response to visual food cues in adults with obesity: A cross‐sectional functional <scp>MRI</scp> study

Perakakis, Nikolaos; Farr, Olivia M.; Mantzoros, Christos S.

doi:10.1111/dom.14315

Cited by 12 publications

(6 citation statements)

References 19 publications

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“…To assess a possible correlation between reward responses and ghrelin levels, they limited their analysis to the insula and found no significant correlation in any of the groups (Steele et al, 2015). One study that assessed whole-brain activations did not find any association between fasting ghrelin levels and anticipatory food reward responses (Perakakis et al, 2021). Finally, two other studies found negative correlations with activation in dlPFC, right caudate, limbic and paralimbic regions (Bogdanov et al, 2020; Karra et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

“…Baseline scores of emotional eating affected the early sensitivity to liraglutide treatment in participants with T2D, and emotional eating was associated with attenuated liraglutide-induced decreases in anticipatory food reward responses in the amygdala, insula, and caudate, as well as attenuated increases in consummatory responses in the insula and caudate (van Bloemendaal et al, 2015b; van Ruiten et al, 2022). However, another study found no significant correlation between endogenous GLP-1 levels and anticipatory activation for food cues (Perakakis et al, 2021). Interestingly, one study reported no correlation between GLP-1 and DLPFC response to food cues, but found that the interaction between GLP-1 levels and DLPFC response robustly predicted body weight change (Maurer et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

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How gut hormones shape reward: a systematic review of the role of ghrelin and GLP-1 in human fMRI

Schulz

Vezzani

Kroemer

2022

Preprint

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The gastrointestinal hormones ghrelin and glucagon-like peptide-1 (GLP-1) have opposite secretion patterns, as well as opposite effects on metabolism and food intake. Beyond their role in energy homeostasis, gastrointestinal hormones have also been suggested to modulate the reward system. However, the potential of ghrelin and GLP-1 to modulate reward responses in humans has not been systematically reviewed before. To evaluate the convergence of published results, we first conduct a multi-level kernel density meta-analysis of studies reporting a positive association of ghrelin (Ncomb = 353, 18 contrasts) and a negative association of GLP-1 (Ncomb = 258, 12 contrasts) and reward responses measured using task functional magnetic resonance imaging (fMRI). Second, we complement the meta-analysis using a systematic literature review, focusing on distinct reward phases and applications in clinical populations that may account for variability across studies. In line with preclinical research, we find that ghrelin increases reward responses across studies in key nodes of the motivational circuit, such as the nucleus accumbens, pallidum, putamen, substantia nigra, ventral tegmental area, and the dorsal mid insula. In contrast, for GLP-1, we did not find sufficient convergence in support of reduced reward responses. Instead, our systematic review identifies potential differences of GLP-1 on anticipatory versus consummatory reward responses. Based on a systematic synthesis of available findings, we conclude that there is considerable support for the neuromodulatory potential of gut-based circulating peptides on reward responses. To unlock their potential for clinical applications, future studies may move beyond anticipated rewards to cover other reward facets.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

How gut hormones shape reward: a systematic review of the role of ghrelin and GLP-1 in human fMRI

Schulz

Vezzani

Kroemer

2022

Preprint

View full text Add to dashboard Cite

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Section: 1mentioning

confidence: 99%

How gut hormones shape reward: A systematic review of the role of ghrelin and GLP-1 in human fMRI

Schulz

Vezzani

Kroemer

2023

Physiology & Behavior

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“…5,6 Further, a 2021 randomized controlled trial using functional magnetic resonance imaging (MRI) showed that high fasting circulating levels of oxyntomodulin were significantly associated with decreased activation of the brain reward system in obese people, providing the strongest evidence to date that the effect of oxyntomodulin on weight loss involves stimulation of the brain. 7 Although the pharmacological effects of oxyntomodulin have mostly been studied in the context of weight loss, several studies have also demonstrated its beneficial effects on improving insulin secretion and glucose metabolism in type 2 diabetes mellitus. 8 Further, investigations of gut peptides (including oxyntomodulin) in individuals with postpancreatitis diabetes mellitus have recently gained momentum.…”

mentioning

confidence: 99%

“…Oxyntomodulin has been shown to cause weight loss in overweight and obese humans by lowering their food intake and increasing their energy expenditure 5,6 . Further, a 2021 randomized controlled trial using functional magnetic resonance imaging (MRI) showed that high fasting circulating levels of oxyntomodulin were significantly associated with decreased activation of the brain reward system in obese people, providing the strongest evidence to date that the effect of oxyntomodulin on weight loss involves stimulation of the brain 7 …”

mentioning

confidence: 99%

Factors Affecting the Circulating Levels of Oxyntomodulin in Health and After Acute Pancreatitis

Bharmal

Kimita

et al. 2022

Pancreas

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ObjectivesTo investigate the factors associated with the circulating levels of oxyntomodulin in healthy individuals and individuals after an episode of acute pancreatitis (AP).MethodsBlood samples were collected from all participants after an overnight fast and analyzed for 28 biomarkers. Participants also underwent comprehensive body composition analysis on a 3-T magnetic resonance imaging scanner. Regression analyses were done to investigate the associations between oxyntomodulin and the studied factors.ResultsThe study included 105 individuals who had a primary diagnosis of AP and 58 healthy individuals. Peptide YY (B coefficient, 0.094; 95% confidence interval [95% CI], 0.164–0.123), pancreatic polypeptide (0.048; 95% CI, 0.030–0.066), and leptin (0.394; 95% CI, 0.128–0.661) had significant associations with oxyntomodulin in healthy individuals. Peptide YY was the most prominent factor associated with oxyntomodulin, explaining 60% of its variance in health. Cholecystokinin (0.014; 95% CI, 0.010–0.018), amylin (−0.107; 95% CI, −0.192 to −0.021), and glycated hemoglobin (−0.761; 95% CI, −1.249 to −0.273) had significant associations with oxyntomodulin in individuals after AP. Cholecystokinin was the most prominent factor associated with oxyntomodulin, explaining 44% of its variance after AP.ConclusionsFactors affecting the circulating levels of oxyntomodulin are different in health and after AP. These insights will enable the determination of populations that benefit from oxyntomodulin therapeutics in the future.

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Fasting oxyntomodulin, glicentin, and gastric inhibitory polypeptide levels are associated with activation of reward‐ and attention‐related brain centres in response to visual food cues in adults with obesity: A cross‐sectional functional MRI study

Cited by 12 publications

References 19 publications

How gut hormones shape reward: a systematic review of the role of ghrelin and GLP-1 in human fMRI

How gut hormones shape reward: a systematic review of the role of ghrelin and GLP-1 in human fMRI

How gut hormones shape reward: A systematic review of the role of ghrelin and GLP-1 in human fMRI

Factors Affecting the Circulating Levels of Oxyntomodulin in Health and After Acute Pancreatitis

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