Fasting Serum Glucose Level and Cancer Risk in Korean Men and Women

Jee, Sun Ha

doi:10.1001/jama.293.2.194

Cited by 876 publications

(919 citation statements)

References 31 publications

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“…This view is supported by large observational studies that have demonstrated a strong relationship between elevated blood glucose and cancer incidence and mortality rates [25,26]. The hyperglycaemia risk relationship appears to be consistent across all levels of blood glucose, even within the normoglycaemic range [25].…”

Section: Epidemiological Datamentioning

confidence: 81%

Insulin, glucose and the increased risk of cancer in patients with type 2 diabetes

Johnson

Pollak

2010

Diabetologia

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Section: Epidemiological Datamentioning

confidence: 81%

Insulin, glucose and the increased risk of cancer in patients with type 2 diabetes

Johnson

Pollak

2010

Diabetologia

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“…These experimental studies support a biologic mechanism whereby elevated concentrations of serum insulin may promote the development of pancreatic ductal carcinoma. Further support for this mechanisms is lent by epidemiologic studies in which prediagnostic elevations in fasting serum glucose, post-load plasma glucose, and fasting serum insulin have been associated with an elevated risk of pancreatic cancer (Gapstur et al, 2000;Jee et al, 2005;StolzenbergSolomon et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts

et al. 2007

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Insulin-like growth factor (IGF)-I induces growth in pancreatic cancer cells and blockade of the IGF-I receptor has antitumour activity. The association of plasma IGF-I and IGF binding protein-3 (IGFBP-3) with pancreatic cancer risk has been investigated in two small studies, with conflicting results. We conducted a nested case -control study within four large, prospective cohorts to investigate whether prediagnostic plasma levels of IGF-I, IGF-II, and IGFBP-3 were associated with pancreatic cancer risk. Plasma levels in 212 cases and 635 matched controls were compared by conditional logistic regression, with adjustment for other known pancreatic cancer risk factors. No association was observed between plasma levels of IGF-I, IGF-II, or IGFBP-3 and incident diagnosis of pancreatic cancer. Relative risks for the highest vs the lowest quartile of IGF-I, IGF-II, and IGFBP-3 were 0.94 (95% confidence interval (CI), 0.60 -1.48), 0.96 (95% CI, 0.61 -1.52), and 1.21 (95% CI, 0.75 -1.92), respectively. The relative risk for the molar ratio of IGF-I and IGFBP-3, a surrogate measure for free IGF-I, was 0.84 (95% CI, 0.54 -1.31). Additionally, no association was noted in stratified analyses or when requiring longer follow-up. In four prospective cohorts, we found no association between the risk of pancreatic cancer and prediagnostic plasma levels of IGF-I, IGF-II, or IGFBP-3.

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“…An Italian case-control study found a positive interaction between diabetes and overweight: the OR for diabetes was 3.3 among subjects with BMIX25 kg/m 2 and 1.4 in those with BMIo25 kg/m 2 (La . On the other hand, a Korean cohort study showed a linear increase in HCC risk with increasing fasting serum glucose for each category of BMI, thus showing no interaction between diabetes and BMI on HCC risk (Jee et al, 2005).…”

Section: Diabetes and Hepatocellular Carcinomamentioning

confidence: 90%

“…Further evidence comes from some recently published large cohort studies from the USA and Korea, which used selfreported questionnaire-based data, hospital discharge diagnosis databases or medical evaluations (Nair et al, 2002;Coughlin et al, 2004;El-Serag et al, 2004;Jee et al, 2005). They all found a twofold increased incidence in mortality rate for liver cancer among diabetics compared to non-diabetics, after controlling for BMI, heavy alcohol intake and other confounders.…”

Section: Diabetes and Hepatocellular Carcinomamentioning

confidence: 99%

“…They all found a twofold increased incidence in mortality rate for liver cancer among diabetics compared to non-diabetics, after controlling for BMI, heavy alcohol intake and other confounders. Furthermore, the Korean study found that elevated fasting serum glucose was an independent risk factor for liver cancer incidence, especially in men, with a doseresponse relation (Jee et al, 2005).…”

Section: Diabetes and Hepatocellular Carcinomamentioning

confidence: 99%

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Southern Europe as an example of interaction between various environmental factors: a systematic review of the epidemiologic evidence

et al. 2006

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Hepatitis B virus (HBV), hepatitis C virus (HCV) and alcohol consumption are major causes of hepatocellular carcinoma (HCC) worldwide. We performed a systematic review of epidemiologic studies carried out on HCC aetiology in Southern Europe, an area with an intermediatehigh prevalence of these agents as well as of putative risk factors such as tobacco smoking, diabetes and obesity. To retrieve the articles, we performed a Medline search for titles and abstracts of articles. After the Medline search, we reviewed the papers and reference lists to identify additional articles. A synergism between HCV infection and HBV infection, overt (hepatitis B virus antigen (HbsAg) positivity) or occult (HBsAg negativity with presence of HBV DNA in liver or serum), is suggested by the results of some studies. The pattern of the risk for HCC due to alcohol intake shows a continuous dose-effect curve without a definite threshold, although most studies found that HCC risk increased only for alcohol consumption above 40-60 g of ethanol per day. Some evidence supports a positive interaction of alcohol intake probably with HCV infection and possibly with HBV infection. A few studies found that coffee has a protective effect on HCC risk due to various risk factors. Some data also support a role of tobacco smoking, diabetes and obesity as single agents or preferably cofactors in causing HCC. In countries with a relatively high alcohol consumption and intermediate levels of HCV and HBV infections (1-3% of population infected by each virus), such as Mediterranean countries, the three main risk factors together account for about 85% of the total HCC cases, leaving little space to other known risk factors, such as haemochromatosis, and to new, still unrecognised, factors as independent causes of HCC.

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Fasting Serum Glucose Level and Cancer Risk in Korean Men and Women

Abstract: For editorial comment see p 235.

Cited by 876 publications

References 31 publications

Insulin, glucose and the increased risk of cancer in patients with type 2 diabetes

Insulin, glucose and the increased risk of cancer in patients with type 2 diabetes

Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts

Southern Europe as an example of interaction between various environmental factors: a systematic review of the epidemiologic evidence

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