Fasting Serum Long-Acting Natriuretic Peptide Correlates With the Ankle Brachial Index in Renal Transplant Recipients

Ho, Guan-Jin; Chen, Yen-Cheng; Yin, Weiqiang; Chang, Yao-Jen; Lee, Ming-Che; Hsu, Bang‐Gee

doi:10.6002/ect.2012.0224

Cited by 4 publications

(3 citation statements)

References 62 publications

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“…Using an oscillometric method, ABI values were measured using an ABI-form device (VaSera VS-1000; Fukuda Denshi Co, Ltd, Tokyo, Japan) that automatically and simultaneously measures BP in both arms and ankles [13]. With the participants lying in the supine position, occlusion and monitoring cuffs were placed tightly around the four extremities, and an electrocardiogram was recorded and the heart sounds were measured for at least 10 min.…”

Section: Methodsmentioning

confidence: 99%

High serum resistin levels are associated with peripheral artery disease in the hypertensive patients

Hsu

Lee

Yang

et al. 2017

BMC Cardiovasc Disord

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BackgroundHypertension is a risk factor for peripheral arterial disease (PAD). Subjects with PAD are at increased risk of future cardiovascular (CV) events. Resistin is involved in the pathological processes of CV diseases. The aim of this study is to investigate whether resistin level is correlated with PAD in hypertensive patients.MethodsOne hundred and twenty-four hypertensive patients were enrolled in this study. Ankle-brachial index (ABI) values were measured using the automated oscillometric method. An ABI value < 0.9 defined the low ABI group. Anthropometric analysis with waist circumference and body mass index, and fasting serum levels of blood urea nitrogen, creatinine, glucose, total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total calcium, phosphorus, and high-sensitivity C-reactive protein (hs-CRP) were measured using standard enzymatic automated methods. Serum levels of human resistin were determined using a commercially available enzyme immunoassay.ResultsEighteen hypertensive patients (14.5%) were included in the low ABI group. Hypertensive patients in the low ABI group were older (p = 0.043) and had higher serum creatinine (p < 0.001), high-sensitivity C-reactive protein (hs-CRP; p = 0.013), and resistin (p < 0.001) levels but a lower estimated glomerular filtration rate (p = 0.002) than patients in the normal ABI group. After the adjustment for factors that were significantly associated with PAD on multivariate logistic regression analysis, serum resistin (odds ratio [OR], 1.176; 95% confidence interval [CI], 1.028–1.345; p = 0.018) was also an independent predictor of PAD in hypertensive patients.ConclusionsA high serum resistin level is an independent predictor of PAD in hypertensive patients.

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Section: Methodsmentioning

confidence: 99%

High serum resistin levels are associated with peripheral artery disease in the hypertensive patients

Hsu

Lee

Yang

et al. 2017

BMC Cardiovasc Disord

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“…Using an oscillometric method, ABI values were measured using an ABI-form device (VaSera VS-1000; Fukuda Denshi Co., Ltd., Tokyo, Japan) that automatically and simultaneously measures BP in both arms and ankles [ 16 ]. With the participants lying in the supine position, occlusion and monitoring cuffs were placed tightly around the four extremities, an electrocardiogram was recorded, and heart sounds were measured for at least 10 min.…”

Section: Aterials and Methodsmentioning

confidence: 99%

Association of hyperleptinemia with peripheral arterial disease in hypertensive patients

et al. 2017

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Objective:Hypertension is a risk factor for peripheral artery disease (PAD). Serum leptin plays an important role in promoting endothelial dysfunction. The aim of this study is to investigate whether the leptin level is associated with PAD in hypertensive patients.Materials and Methods:Ninety-eight hypertensive patients were enrolled in this study. Ankle-brachial index (ABI) values were measured using an automated oscillometric device. Patients with an ABI value <0.9 were considered the low ABI group. C-reactive protein (CRP) was measured using standard enzymatic automated methods. Serum levels of human leptin were determined using a commercially available enzyme immunoassay.Results:Eighteen (18.4%) hypertensive patients were included in the low ABI group. Hypertensive patients in the low ABI group had higher serum creatinine (P < 0.001), CRP (P = 0.003), and leptin (P < 0.001) levels, higher prevalence of diabetes (P = 0.036), and current smoking (P = 0.034) than patients in the normal ABI group. Univariate linear regression analyses revealed that body weight (P = 0.014), waist circumference (P = 0.010), body mass index (P = 0.002), and logarithmically transformed CRP (log-CRP, P = 0.001) were positively correlated with serum log-leptin levels in hypertensive patients. Multivariate stepwise linear regression analysis showed that log-leptin (β = 0.439, adjusted R2 change = 0.224, P < 0.001) was also an associated factor of PAD in hypertensive patients.Conclusion:A higher log-leptin value is an independent predictor of PAD in hypertensive patients.

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“…ABI values were obtained using an oscillometric method. The ABI-form device (VaSera VS-1000; Fukuda Denshi Co., Ltd., Tokyo, Japan) measures blood pressure (BP) in both arms and ankles automatically and simultaneously [ 22 ]. During examination, participants were in the supine position and cuffs were placed tightly around the four extremities.…”

Section: Aterials and M Ethodsmentioning

confidence: 99%

High serum leptin level is associated with peripheral artery disease in adult peritoneal dialysis patients

Lai

Wang

Tsai³

et al. 2018

Tzu Chi Med J

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Objective:Peripheral artery disease (PAD) is associated with systemic atherosclerosis and indicates an increased risk of mortality in peritoneal dialysis (PD) patients. A high leptin level accelerates atherosclerosis in apoE-deficient mice. The purpose of this study was to examine the association of serum leptin level and PAD in adult PD patients.Materials and Methods:The clinical characteristics of sixty PD patients recruited from June 2015 to October 2016 were obtained. Serum leptin concentrations were determined. Ankle–brachial index (ABI) values were measured and those with a left or right ABI <0.9 were defined as the low ABI group.Results:Twenty of these 60 PD patients (33.3%) had diabetes mellitus and 32 patients (53.3%) had hypertension. Thirteen PD patients (21.7%) were in the low ABI group. Higher serum leptin (P = 0.002) and C-reactive protein (CRP, P < 0.001) levels were found in the low ABI group compared with those in the normal ABI group. More number of patients with diabetes (P = 0.015) and current smokers (P = 0.037) were noted in the low ABI group than in the normal ABI group. After adjustment for factors that were significantly associated with PAD in multivariate logistic regression analysis, each increase of 1 ng/mL in the serum leptin level (odds ratio [OR], 1.062; 95% confidence interval [CI], 1.014–1.114; P = 0.012) and each increase of 0.1 mg/dL in the serum CRP level (OR, 1.107; 95% CI, 1.011–1.211; P = 0.028) were found to be independent predictors of PAD in PD patients.Conclusion:Higher serum leptin and CRP levels correlated positively with the diagnosis of PAD in PD patients.

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Fasting Serum Long-Acting Natriuretic Peptide Correlates With the Ankle Brachial Index in Renal Transplant Recipients

Cited by 4 publications

References 62 publications

High serum resistin levels are associated with peripheral artery disease in the hypertensive patients

High serum resistin levels are associated with peripheral artery disease in the hypertensive patients

Association of hyperleptinemia with peripheral arterial disease in hypertensive patients

High serum leptin level is associated with peripheral artery disease in adult peritoneal dialysis patients

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