Fat Embolism Prophylaxis

Shier, Michael R.; Wilson, Robert F.; James, Robert E.; Riddle, Jeanne M.; Mammen, Eberhard F.; Pedersen, Herbert E.

doi:10.1097/00005373-197708000-00009

Cited by 49 publications

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“…First, the fat particles produced by the destruction of adipocytes during cannula movement in the subcutaneous layer enter the surrounding ruptured venules. These fat particles become emboli in the bloodstream and are transported to the pulmonary vascular beds 15 . Fat emboli ranging in size from 10 μm to 40 μm in diameter have been found to block pulmonary blood vessels, leading to increased pulmonary arterial pressure and hypoxia 3 4 .…”

Section: Discussionmentioning

confidence: 99%

“…Fat embolism syndrome was first described by Gurd 14 in 1970. The 3 classic symptoms of fat embolism syndrome—respiratory distress, cerebral dysfunction, and petechial rash—usually appear within 24–72 hours after liposuction in 85% of the affected patients 15 , with a symptom-free interval of 12–30 hours after injury 16 . Major fat embolism syndrome has been suggested to cause clinical symptoms such as tachycardia, tachypnea, fever, and hypoxemia.…”

Section: Discussionmentioning

confidence: 99%

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Correlation between the time elapsed after liposuction and the risk of fat embolism: An animal model

et al. 2018

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BackgroundLiposuction has become one of the most frequently performed procedures in the field of aesthetic surgery. Fat embolism syndrome after liposuction can easily be overlooked or underestimated; however, occasionally, fulminating fat embolism syndrome can develop and lead to a critical situation within 2–3 days after lipoplasty. Changes over time in the amount of circulating fat particles and the histology of major organs have not yet been studied.MethodsThis study was conducted using 18 male Sprague-Dawley rats aged 12 weeks and weighing 500–628 g (average, 562 g). Fifteen rats were used as the experimental group and 3 as the control group. Under general anesthesia, tumescent-technique liposuction was performed at the lateral flank areas and abdomen for 1 hour. Blood, lung, and brain tissue specimens were obtained at 1 hour, 1 day, and 2 days after the liposuction procedure.ResultsThe average number of fat particles in the blood samples was 25,960/dL at 1 hour, 111,100/dL at 24 hours, and 21,780/dL at 48 hours. The differences between study groups were statistically significant. Both intravascular and extravascular fat particles with inflammation were seen in all 15 rats, as were inflammatory cell infiltration, hemorrhage, and consolidation with shrinkage of the lung alveoli.ConclusionsThese results imply that there is a strong possibility of fat embolism syndrome after liposuction in real clinical practice, and the first 24–48 hours after the operation were found to be the most important period for preventing pulmonary embolism and progression to fulminating fat embolism syndrome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Correlation between the time elapsed after liposuction and the risk of fat embolism: An animal model

et al. 2018

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Pulmonary and Cardiovascular Consequences of Immediate Fixation or Conservative Management of Long-Bone Fractures

Lozman¹

1986

Arch Surg

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Bone marrow embolism in sickle cell disease: A review

et al. 2005

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The fat embolism syndrome is an important complication of patients with sickle cell hemoglobinopathies because of severe morbidity and mortality. Our recent experience with three cases that survived with intensive supportive care and prompt use of transfusion stimulates this review. A high index of suspicion, prompt use of diagnostic tools, and aggressive clinical management are the keys to a successful outcome. Am.

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Fat Embolism Prophylaxis

Cited by 49 publications

References 0 publications

Correlation between the time elapsed after liposuction and the risk of fat embolism: An animal model

Correlation between the time elapsed after liposuction and the risk of fat embolism: An animal model

Pulmonary and Cardiovascular Consequences of Immediate Fixation or Conservative Management of Long-Bone Fractures

Bone marrow embolism in sickle cell disease: A review

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