Fat Embolism Syndrome

Bulger, Eileen M.; Smith, Douglas G.; Maier, Ronald V.; Jurkovich, Gregory J.

doi:10.1001/archsurg.1997.01430280109019

Cited by 281 publications

(251 citation statements)

References 13 publications

Supporting

Mentioning

212

Contrasting

Unclassified

Order By: Relevance

“…In a 10-year review in an American level one trauma centre there was an incidence of FES of 0.9% using Gurd's diagnostic criteria [6]. There was no obvious correlation with severity, site or pattern of injury and FES.…”

Section: Incidence Diagnosed By Clinical Criteriamentioning

confidence: 96%

“…Severity is variable but respiratory failure is relatively common. Bulger reported that 44% of the 27 patients diagnosed as having FES required a period of mechanical ventilation [6]. A 15-year study of trauma patients in the West Indies found 14 cases, four of whom required mechanical ventilation [7].…”

Section: Q 2001 Blackwell Science Ltdmentioning

confidence: 99%

“…Thrombocytopaenia (platelet count , 150 Â 10 9 .l 2l ) and unexplained anaemia are common (37% and 67%, respectively) [6]. The mechanism causing thrombocytopaenia is unclear but both platelet activation by bone marrow emboli with thrombus formation and platelet consumption due to disseminated intravascular coagulation (DIC) have been postulated [14].…”

Section: Q 2001 Blackwell Science Ltdmentioning

confidence: 99%

“…Whether early administration of oxygen actually prevents the onset of the syndrome by preventing hypoxaemia, further catecholamine response and fat mobilisation remains unclear. Between 10 and 44% of patients require mechanical ventilation but the pulmonary dysfunction caused by FES usually resolves in 3±7 days [6,7,38].…”

Section: Treatmentmentioning

confidence: 99%

See 3 more Smart Citations

Fat embolism

2001

View full text Add to dashboard Cite

SummaryFat embolism syndrome is a collection of respiratory, haematological, neurological and cutaneous symptoms and signs associated with trauma and other disparate surgical and medical conditions. The incidence of the clinical syndrome is low (, 1% in retrospective reviews) whilst the embolisation of marrow fat appears to be an almost inevitable consequence of long bone fractures. There is debate over the pathogenesis of fat embolism syndrome and it seems a variety of factors interact to produce a spectrum of end organ damage. Many therapeutic interventions and prophylactic strategies have been tried with varying success. Current treatments are supportive and the condition is usually associated with a good outcome. The literature on fat embolism syndrome is extensive and this review aims to discuss the incidence, aetiology, pathophysiology, diagnosis and treatment of fat embolism.

show abstract

Section: Incidence Diagnosed By Clinical Criteriamentioning

confidence: 96%

Section: Q 2001 Blackwell Science Ltdmentioning

confidence: 99%

Section: Q 2001 Blackwell Science Ltdmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

See 2 more Smart Citations

Fat embolism

2001

View full text Add to dashboard Cite

show abstract

“…Gurd criteria defines FES with three major symptoms: pulmonary distress (Pa02<60 mmHg), CNS depression, and petechiae. Hypoxia is the most common manifestation (96 %), followed by CNS depression (59 %) [4]. CNS depression was hypothesized caused by fat emboli.…”

Section: Discussionmentioning

confidence: 99%

Favorable Outcome of Cerebral Fat Embolism Syndrome with a Glasgow Coma Scale of 3: a Case Report and Review of the Literature

et al. 2014

View full text Add to dashboard Cite

Prognosis of deep coma caused by cerebral fat embolism syndrome (CFES) is rarely reported. We present a case of fulminant CFES which was induced by long bone fracture, with a Glasgow Coma Scale (GCS) of 3/15. The brain magnetic resonance imaging (MRI) revealed abnormal spotty lesions scattered over both cerebral hemispheres and the posterior fossa. Thirty days later, the patient regained consciousness with a GCS of 15/15.

show abstract