Fat-forming Solitary Fibrous Tumor of the Kidney – A Case Report and Literature Review

Bacalbaşa, Nicolae; Bălescu, Irina; Jinescu, George; Marcu, Madalina; Contolenco, Andreea; Pop, Doina Mihaela; Dobriţoiu, D.; Ionescu, Olivia; Ionescu, Paris; Stoica, Claudia

doi:10.21873/invivo.11288

Cited by 5 publications

(2 citation statements)

References 14 publications

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“…A few studies showed that pelvic [27,30,41], abdominal [27,42], and pleural [27,40,43] SFTs tend to be larger than tumors appearing in other locations, and extrapleural SFTs may show potentially malignant behavior [44], especially those with limb localization [45]. Generally, over the years, SFTs have been described in various localizations, including the liver [46,47], kidney [48][49][50], pancreas [23,51,52], sigmoid colon [31], mesocolon [14], omentum [53,54], urinary bladder [55], caecum wall [56], mesorectum [41], prostate [57], spermatic cord [58], testis [59], scrotum [60], female gynecological tract, especially the vulva [61,62], vagina [63], breast [64][65][66], heart and pericardium [33,67,68], epicardium [69], pulmonary artery [70], trachea [71], larynx [32,72], tongue [15], salivary glands [73]<...…”

Section: Anatomical Locationmentioning

confidence: 99%

Diagnostics and Treatment of Extrameningeal Solitary Fibrous Tumors

Janik,

Terlecka,

Spałek

et al. 2023

Cancers

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Solitary fibrous tumors (SFT) are rare mesenchymal neoplasms that account for less than 2% of all soft tissue masses. In the latest WHO 2020 Classification of Soft Tissue Tumors, extrameningeal SFT was listed as intermediate (rarely metastasizing) or malignant neoplasms. Due to the lack of characteristic clinical features, their diagnosis and treatment remain challenging. The pathogenesis of SFT is often associated with the presence of fusions of the NAB2-STAT6 gene on the 12q13 chromosome. Cytoplasmic CD34 positive staining is considerably characteristic for most SFTs; less frequently, factor XII, vimentin, bcl-2, and CD99 are present. A key factor in the diagnosis is the prevalent nuclear location of STAT6 expression. Radical resection is the mainstay of localized SFTs. In the case of unresectable disease, only radiotherapy or radio-chemotherapy may significantly ensure long-term local control of primary and metastatic lesions. To date, no practical guidelines have been published for the treatment of advanced or metastatic disease. Classical anthracycline-based chemotherapy is applicable. The latest studies suggest that antiangiogenic therapies should be considered after first-line treatment. Other drugs, such as imatinib, figitumumab, axitinib, and eribulin, are also being tested. Definitive radiotherapy appears to be a promising therapeutic modality. Since standards for the treatment of advanced and metastatic diseases are not available, further investigation of novel agents is necessary.

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Section: Anatomical Locationmentioning

confidence: 99%

Diagnostics and Treatment of Extrameningeal Solitary Fibrous Tumors

Janik,

Terlecka,

Spałek

et al. 2023

Cancers

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“…Solitary fibrous tumors (SFTs) were reported for the first time by Wagner et al [ 1 ] in 1870. As hemangiopericytomas, SFTs are usually benign and arise from mesenchymal spindle cells, typically of the pleura.…”

Section: Introductionmentioning

confidence: 99%

Solitary fibrous tumor of the renal pelvis: A case report

Liu¹,

Zheng²,

Wang³

et al. 2022

WJCC

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BACKGROUND Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm. SFT derived from the renal pelvis is an exceedingly rare entity. In this study, we report a case of renal pelvis SFT and review the relevant literature on this rare tumor. CASE SUMMARY A 76-year-old man was hospitalized due to right lumbar and abdominal pain. Abdominal computed tomography showed a hypervascular space-occupying renal lesion, sized 2.3 cm × 1.8 cm. Based on the computed tomography findings, the patient was diagnosed with right renal pelvis tumor and underwent nephrectomy. Postoperative immunohistochemical results confirmed the diagnosis. As of the 3-year follow-up, there were no signs of recurrence, and the patient has recovered well. CONCLUSION We report a rare case of SFT derived from the renal pelvis and discuss the imaging and histopathological features that distinguish renal pelvis SFT from other renal pelvis tumors.

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Renal Solitary Fibrous Tumor With Müllerian Cysts: A Novel Differential Diagnosis for Biphasic Renal Neoplasms

Saad,

Kilic,

Segura

et al. 2024

Int J Surg Pathol

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Solitary fibrous tumor is an uncommon mesenchymal neoplasm, initially described in the pleura and infrequently found in the kidney. It is characterized by haphazardly arranged spindle cells, staghorn vasculature, coexpression of CD34 and signal transducer and activator of transcription 6 (STAT6), and a NAB2::STAT6 gene fusion. We report a 64-year-old woman who presented with a 2.5 cm multilocular cystic renal mass. On microscopic examination, the tumor consisted of a spindle cell component closely intermingled with ciliated and hemorrhagic epithelial cysts. The spindle cell component was positive for CD34, B-cell lymphoma 2 (BCL2), and STAT6, confirming the diagnosis of a solitary fibrous tumor. The epithelial cysts expressed keratin 7, PAX8, BCL2, estrogen receptor 1, and progesterone receptor, indicative of Müllerian cysts. The occurrence of solitary fibrous tumor in the kidney is extremely rare, and its association with Müllerian cysts has not been previously reported in the kidney. This morphologic variant has a striking similarity with biphasic renal neoplasms, especially with mixed epithelial and stromal tumors and angiomyolipoma with epithelial cysts. This report describes a novel renal solitary fibrous tumor subtype within this differential and underscores clinical and pathological distinctions of biphasic renal neoplasms.

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Fat-forming Solitary Fibrous Tumor of the Kidney – A Case Report and Literature Review

Cited by 5 publications

References 14 publications

Diagnostics and Treatment of Extrameningeal Solitary Fibrous Tumors

Diagnostics and Treatment of Extrameningeal Solitary Fibrous Tumors

Solitary fibrous tumor of the renal pelvis: A case report

Renal Solitary Fibrous Tumor With Müllerian Cysts: A Novel Differential Diagnosis for Biphasic Renal Neoplasms

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