Fat‐Free Mass and Skeletal Muscle Mass Five Years After Bariatric Surgery

Davidson, Lance E.; Yu, Wen Liang; Goodpaster, Bret H.; DeLany, James P.; Widen, Elizabeth M.; Lemos, Thaisa; Strain, Gladys; Pomp, Alfons; Courcoulas, Anita P.; Lin, Susan; Janumala, Isaiah; Thornton, John C.; Gallagher, Dympna

doi:10.1002/oby.22190

Cited by 66 publications

(54 citation statements)

References 39 publications

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“…Davidson et al 22 compare the changes after RYGB, SG and adjustable gastric band (BAND) obtaining the lowest mean weight results at 12 months after surgery, as in our study, in RYGB and SG (79.8 ± 16.3 kg vs. 104.3 ± 25.2 kg, respectively). FFM before RYGB was higher in men than in women (57.6 ± 8.4 kg vs. 74.9 ± 9.3 kg); these values were similar to those described in our study (54.71 ± 6.96 kg vs. 73.14 ± 11.49 kg).…”

Section: Discussionsupporting

confidence: 64%

“…The mean values of FFM after a year of RYGB and OAGB in women (50.4 ± 7.1 kg vs. 46.03 ± 4.65 kg) and men (46.03 ± 4.65 kg vs. 66.25 ± 8.14 kg) followed the same trend, considering that in the study by Davidson et al . the mean preoperative weight was lower than in the OAGB, both in women and men (123.1 ± 18.9 kg vs. 143.8 ± 17.2 kg) 22 .…”

Section: Discussionmentioning

confidence: 62%

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Assessment of body composition in obese patients undergoing one anastomosis gastric bypass: cross-sectional study

Jiménez

Ruíz-Tóvar²,

López

et al. 2020

Sci Rep

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Bariatric surgery is the most effective long-term treatment to obesity, and it is necessary to assess changes in body composition and to be able to establish better follow-up of patients. Cross-sectional, observational study in patients undergoing One Anastomosis Gastric Bypass (OAGB) bariatric surgery. We analysed changes in weight and body composition during the first postoperative year. 405 patients (68.9% women. 31.1% men), mean age 44 years, mean weight 110.02 kg, Body Mass Index (BMI) 39.76 kg/m2, height 1.66 m. The variables analyzed were substantially decreased compared to the preoperative values one year after surgery in every case: weight (110.02 ± 22.03 kg vs. 69.36 ± 13.60 kg), BMI (39.76 ± 6.65 vs. 24.52 ± 3. 76), fat free mass (61.12 ± 12.43 kg vs. 53.61 ± 11.61 kg), fat mass (50.44 ± 14.36 kg vs. 15.74 ± 6.74 kg), bone mass (58.06 ± 11.85 kg vs. 50.92 ± 11.06 kg) and water (45.08 ± 9.99 kg vs. 37.39 ± 9.23 kg), P < 0.001. The results show noticeable improvements in weight reduction and changes in body composition, and will contribute to develop a thorough understanding of both of them, contributing also to perform a better patients’ follow-up.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 62%

Assessment of body composition in obese patients undergoing one anastomosis gastric bypass: cross-sectional study

Jiménez

Ruíz-Tóvar²,

López

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…We also observed a trend toward decreased lean mass in Pp2cm KO HFD-VSG mice compared to their Pp2cm KO HFD-sham controls ( Figure 7F ). Muscle loss is a common side effect of rapid weight loss interventions, including bariatric surgery in humans ( Davidson et al, 2018 ; Friedrich et al, 2013 ; Kenngott et al, 2019 ; Moizèet al, 2013 ). BCAA supplementation with HFD induces a chronic activation of mTORC1 in skeletal muscle in rats ( Newgard et al, 2009 ).…”

Section: Discussionmentioning

confidence: 99%

The Role of Elevated Branched-Chain Amino Acids in the Effects of Vertical Sleeve Gastrectomy to Reduce Weight and Improve Glucose Regulation

et al. 2020

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SUMMARY Elevated levels of branched-chain amino acids (BCAAs) and their metabolites are strongly positively associated with obesity, insulin resistance, and type 2 diabetes. Bariatric surgery is among the best treatments for weight loss and associated morbidities. Clinical studies have reported that bariatric surgery decreases the circulating levels of BCAAs. The objective of this study was to test the hypothesis that reduced BCAA levels contribute to the metabolic improvements of sustained weight loss and improved glucose tolerance after vertical sleeve gastrectomy (VSG). We find that, as in humans, circulating BCAAs are significantly lower in VSG rats and mice. To increase circulating BCAAs, we tested mice with either increased dietary intake of BCAAs or impaired BCAA catabolism by total body deletion of mitochondrial phosphatase 2C (Pp2cm). Our results show that a decrease in circulating BCAAs is not necessary for sustained body weight loss and improved glucose tolerance after VSG.

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“…We also observed a trend toward decreased lean mass in Pp2cm KO HFD-VSG mice compared to their Pp2cm KO HFD-Sham controls ( Figure 7F). Muscle loss is a common side-effect of rapid weight loss interventions, including bariatric surgery in humans (50)(51)(52)(53). BCAA supplementation with high-fat diet induces a chronic activation of mTORC1 in skeletal muscle (1).…”

Section: Discussionmentioning

confidence: 99%

The role of elevated branched chain amino acids in the potent effects of vertical sleeve gastrectomy to reduce weight and improve glucose regulation in mice

Bozadjieva-Kramer

Evers

Shin

et al. 2020

Preprint

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Obesity and type 2 diabetes mellitus (T2D) are growing epidemics resulting in increased morbidity and mortality. An emerging body of evidence has shown that elevated levels of branched-chain amino acids (BCAA) and their metabolites are strongly positively associated with obesity, insulin-resistance and T2D. Bariatric surgery is among the best treatments for weight loss and the alleviation of T2D. Additionally, clinical studies have reported that bariatric surgery decreases the circulating levels of BCAA. The objective of these studies was to test the hypothesis that reduced BCAA levels contribute to the metabolic improvements after VSG. We find that, as in humans, circulating BCAA levels are significantly lower in VSG rats and mice compared to Sham controls. In order to increase circulating BCAA levels, we tested mice with either increased dietary intake of BCAA or impaired BCAA catabolism by total body deletion of mitochondrial phosphatase 2C, Pp2cm, a key enzyme in the rate-limiting step in BCAA catabolism. Our results show that a decrease in circulating BCAA levels is not necessary for sustained body weight loss and improved glucose tolerance after VSG. While it is clear that circulating levels of BCAAs are excellent biomarkers for metabolic status, the current data do not support a causal role in determining metabolic regulation and the response to VSG.

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Fat‐Free Mass and Skeletal Muscle Mass Five Years After Bariatric Surgery

Cited by 66 publications

References 39 publications

Assessment of body composition in obese patients undergoing one anastomosis gastric bypass: cross-sectional study

Assessment of body composition in obese patients undergoing one anastomosis gastric bypass: cross-sectional study

The Role of Elevated Branched-Chain Amino Acids in the Effects of Vertical Sleeve Gastrectomy to Reduce Weight and Improve Glucose Regulation

The role of elevated branched chain amino acids in the potent effects of vertical sleeve gastrectomy to reduce weight and improve glucose regulation in mice

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