Fat-Free Mass, Strength, and Sarcopenia are Related to Bone Mineral Density in Older Women

Lima, Ricardo Moreno; Bezerra, Lídia Mara Aguiar; Rabelo, Heloisa Thomaz; Silva, Maria A.F.; Silva, Antonio J.R.; Bottaro, Martim; Oliveira, Ricardo Jacó de

doi:10.1016/j.jocd.2008.10.003

Cited by 91 publications

(82 citation statements)

References 34 publications

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“…Alterations that are widely recognized by gerontologists include the decline in both fat-free mass (FFM) and muscle strength, a process that has been referred to as sarcopenia (1). The term sarcopenia comes from the Greek words sarx (flesh) and penia (deficiency) and was originally proposed to refer to the involuntary loss of muscle mass that commonly occurs with advancing age (1)(2)(3)(4). This phenomenon has been described in both elderly men and women (2) and has been linked to multiple negative clinical outcomes (2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

“…The term sarcopenia comes from the Greek words sarx (flesh) and penia (deficiency) and was originally proposed to refer to the involuntary loss of muscle mass that commonly occurs with advancing age (1)(2)(3)(4). This phenomenon has been described in both elderly men and women (2) and has been linked to multiple negative clinical outcomes (2)(3)(4). Sarcopenia imposes an important economic onus on health care costs (5), and thus efforts to understand and counteract this condition are meaningful.…”

Section: Introductionmentioning

confidence: 99%

“…Dualenergy X-ray absorptiometry (DXA) has become a practical technique for measuring total body FFM and fat mass (FM) in clinical and research settings (2)(3)(4)6). Moreover, DXA permits measurements of FFM and FM for the trunk, arms, and legs.…”

Section: Introductionmentioning

confidence: 99%

“…This approach showed that deficiency in muscle mass increases with age and the prevalence of sarcopenia is associated with a significantly higher risk of disability in elderly individuals. However, in addition to the decline in FFM, older individuals also tend to gain weight, especially fat mass, as they age (3). Therefore, an expanding literature in this area has been focusing on a high FM/low FFM combination (4), a condition referred to as sarcopenic obesity (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Identification of sarcopenic obesity in postmenopausal women: a cutoff proposal

Oliveira

Bottaro

Júnior

et al. 2011

Braz J Med Biol Res

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Identification of sarcopenic obesity in postmenopausal women: a cutoff proposal

Oliveira

Bottaro

Júnior

et al. 2011

Braz J Med Biol Res

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“…(SILVA et al 2006;LIMA et al, 2009;OLIVEIRA et al, 2009). De fato, relatos prévios fornecem evidências de que a sarcopenia apresenta relevante implicação nos custos assistenciais em saúde (JANSSEN et al, 2004).…”

Section: Introductionunclassified

Estudo de associação entre força muscular e massa magra em mulheres idosas

Lima¹,

Ernesto²,

Bezerra³

et al. 2012

Rev. Bras. Ciênc. Esporte

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Associations Between Lean Mass, Muscle Strength and Power, and Skeletal Size, Density and Strength in Older Men

Chalhoub

Boudreau

Greenspan

et al. 2018

Journal of Bone and Mineral Research

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Studies examining the relationship between muscle parameters and bone strength have not included multiple muscle measurements and/or both central and peripheral skeletal parameters. The purpose of this study was to explore the relationship between lean mass, muscle strength and power, and skeletal size, bone density, and bone strength. We studied the association between appendicular lean mass (AL M), grip strength, and leg power, and central quantitative computed tomography (QCT) parameters in 2857 men aged 65 years or older; peripheral QCT was available on a subset (n = 786). ALM, grip strength, and leg power were measured by dual-energy X-ray absorptiometry (DXA), Jamar dynamometer, and the Nottingham Power Rig, respectively. Multivariable models adjusting for potential confounders including age, race, study site, BMI, and muscle measurements were developed and least squares means were generated from linear regression models. For the multivariable model, percent differences of bone parameters between lowest (Q1) and highest quartiles (Q4) of ALM, grip strength, and leg power were reported. ALM was significantly associated with central and peripheral QCT parameters: percent higher values (Q4 versus Q1) ranging from 3.3% (cortical volumetric bone mineral density [vBMD] of the femoral neck) to 31% (vertebral strength index of the spine). Grip strength was only significantly associated with radial parameters: percent higher values (Q4 versus Q1) ranging from 2.5% (periosteal circumference) to 7.5% (33% axial strength index [SSIx]). Leg power was associated with vertebral strength and lower cross-sectional area with percent lower values (Q4 versus Q1) of –11.9% and –2.7%, respectively. In older men, stronger associations were observed for ALM compared to muscle strength and power. Longitudinal studies are needed to examine the relationship between independent changes in muscle measurements and skeletal size, density and strength.

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Fat-Free Mass, Strength, and Sarcopenia are Related to Bone Mineral Density in Older Women

Cited by 91 publications

References 34 publications

Identification of sarcopenic obesity in postmenopausal women: a cutoff proposal

Identification of sarcopenic obesity in postmenopausal women: a cutoff proposal

Estudo de associação entre força muscular e massa magra em mulheres idosas

Associations Between Lean Mass, Muscle Strength and Power, and Skeletal Size, Density and Strength in Older Men

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