Fat grafting accelerates revascularisation and decreases fibrosis following thermal injury

Sultan, Steven M.; Barr, Jason; Butala, Parag; Davidson, Edward H.; Weinstein, Andrew L.; Knobel, Denis; Saadeh, Pierre B.; Warren, Stephen M.; Coleman, Sydney R.; Hazen, Alexes

doi:10.1016/j.bjps.2011.08.046

Cited by 104 publications

(87 citation statements)

References 23 publications

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“…[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] The case-control study evaluated scars of 20 randomly selected patients. Each scar was treated half with fat and half with saline injection and evaluated by the Patient and Observer Scar Assessment Scale 25 and Durometer measurement for scar firmness.…”

Section: Case-control Studiesmentioning

confidence: 99%

Fat Grafting and Adipose-Derived Regenerative Cells in Burn Wound Healing and Scarring

Condé-Green

Marano

Lee

et al. 2016

Plastic and Reconstructive Surgery

131

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Section: Case-control Studiesmentioning

confidence: 99%

Fat Grafting and Adipose-Derived Regenerative Cells in Burn Wound Healing and Scarring

Condé-Green

Marano

Lee

et al. 2016

Plastic and Reconstructive Surgery

131

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“…In turn, this resulted in decreased fibrosis, as measured by Sirius red staining and chemical markers [14].…”

Section: Discussionmentioning

confidence: 99%

“…This clinical application has been widened to include treatment of scars with injection of adipose tissue harvested from abdominal subcutaneous fat and processed according to Coleman's technique [13,14].…”

Section: Discussionmentioning

confidence: 99%

Histological study of the role of fat injection in scar remodeling following burn injury

Embaby

El-Shaer

Abdl-Hasib

et al. 2012

The Egyptian Journal of Histology

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BackgroundFat grafting had been shown clinically to improve the quality of burn scars. The mechanism of fat graft survival was not clear, and the role of adipose-derived stem cells and preadipocytes in fat survival remains to be determined. Aim of the work To clinically and histologically evaluate the role of fat grafting in postburn mature scars. Patients and methodsThis study was conducted on 20 postburn mature scars. Patients' ages ranged from 18 to 38 years. Patients were selected randomly to be treated with structural fat graft. It was performed twice for the same scar at a 3-month interval. The abdomen and buttocks were the most commonly chosen donor sites. Fat was processed according to Coleman's technique and injected at the dermohypodermal junction. ResultsFat grafting proved to have a significant role in scar remodeling. This was measured clinically by Vancouver Scar Scale and proved by histological examination of skin biopsy. The skin biopsies taken from scar sites preoperatively and 3 and 6 months after injection showed significant changes in epidermal thickness, appearance of newly formed vessels, healthy collagen deposition, and new hair follicles and sweat and sebaceous glands surrounded by fat cells. ConclusionThe autotransplanted harvested fat after centrifugation led to the formation of new healthy collagen bundles and new dermal and epidermal cells replacing the diseased ones. This could be attributed to the presence of adipose-derived stem cells, which are considered the key to the scar remodeling process.

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“…[1][2][3][4][6][7][8][9][10][11][12][13][14][15][16] Nine of the 15 studies were classified as level IV (case series), two as level III (a retrospective cohort and a comparative clinical study), one as level II (prospective cohort study), and three were not classified (for dealing with animal studies or review articles). No level I studies were found, that is, those with the strongest evidence (controlled and randomized clinical trials).…”

Section: Resultsmentioning

confidence: 99%

“…In the last decade, recognition of the regenerative potential of fatty tissue has indicated clinical improvement of hypertrophic scars in burn patients. 11 The use of fat grafting has been extended even for the treatment of neuropathic pain originating from scar tissue, with improvement in the postoperative period of such patients. 12 In most of the articles analyzed, the Coleman technique 17 was used as the standard for obtaining the fatty tissue for realization of the autologous fat graft.…”

Section: Discussionmentioning

confidence: 99%

Evidences of autologous fat grafting for the treatment of keloids and hypertrophic scars

Silva

Neto

Horácio

et al. 2016

Rev. Assoc. Med. Bras.

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SUMMARY Introduction Since the 1980s, the use of autologous fat grafting has been growing in plastic surgery. Recently, this procedure has come to be used as a treatment for keloids and hypertrophic scars mainly due to the lack of satisfactory results with other techniques. So far, however, it lacks more consistent scientific evidence to recommend its use. The aim of this study was to review the current state of autologous fat grafting for the treatment of keloids and hypertrophic scars, their benefits and scientific evidences in the literature. Method A review in the Pubmed database was performed using the keywords “fat grafting and scar”, “fat grafting and keloid scar” and “fat grafting and hypertrophic scar.” Inclusion criteria were articles written in English and published in the last 10 years, resulting in 15 studies. Results These articles indicate that autologous fat grafting carried out at sites with pathological scars leads to a reduction of the fibrosis and pain, an increased range of movement in areas of scar contraction, an increase in their flexibility, resulting in a better quality of scars. Conclusion So far, evidences suggest that autologous fat grafting for the treatment of keloids and hypertrophic scars is associated with a better quality of scars, leading to esthetic and functional benefits. However, this review has limitations and these findings should be treated with reservations, since they mostly came from studies with low levels of evidence.

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Fat grafting accelerates revascularisation and decreases fibrosis following thermal injury

Cited by 104 publications

References 23 publications

Fat Grafting and Adipose-Derived Regenerative Cells in Burn Wound Healing and Scarring

Fat Grafting and Adipose-Derived Regenerative Cells in Burn Wound Healing and Scarring

Histological study of the role of fat injection in scar remodeling following burn injury

Evidences of autologous fat grafting for the treatment of keloids and hypertrophic scars

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