Background: Moderate facial depression is an important manifestation of aging, and traditional fat grafting is filled through the skin approach, and there may be damage to the terminal branch of the surface artery, thereby increasing the risk of fat embolism, so there is a safety implication. Therefore, a safe and effective filling pathway is a key point in the study of facial fat grafting in the suborbital area. Based on the results of anatomical research, this study looks for the filling level of non-well-known blood vessels, improves the path and surgical method of suborbital fat grafting in the suborbital region, and discusses the treatment of intraoral fat grafting through oral incision in the suborbital region Efficacy and safety.Methods: In this study, 107 patients who visited our hospital from January 2017 to January 2022 all had local depressions in the suborbital area and facial asymmetry, requiring fat grafting to improve. The age range of patients is 28-50 years, with an average age of 38 years. The effectiveness of the operation is assessed based on the patient's self-evaluation and a comparison of preoperative and postoperative photographs. A grading scale is used in the first half of the postoperative period for patient satisfaction assessment.Results: A total of 107 patients were followed for 6 to 24 months, with an average follow-up time of 12 months, 67.3% of patients said "very satisfied", 29.0% of patients said "satisfied", 3.7% of patients said "average", and no patients rated the results as "not satisfied". No complications such as skin ulcers, infections, local indurations, and fat liquefaction occurred after surgery.Conclusions: Fat grafting through oral incision is a safe and effective way to improve fat depression in the suborbital area, in addition, it is necessary to pay attention to preoperative and postoperative oral disinfection and care during this operation to prevent the occurrence of complications such as fat infection.