Fat Grafts Supplemented with Adipose-Derived Stromal Cells in the Rehabilitation of Patients with Craniofacial Microsomia

Tanikawa, Daniela Yukie Sakai; Aguena, Meire; Bueno, Daniela Franco; Passos‐Bueno, Maria Rita; Alonso, Nivaldo

doi:10.1097/prs.0b013e3182910a82

Cited by 127 publications

(111 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A study of 14 patients showed that this method may be safe and effective, and even superior in clinical application to standard lipoinjection. The surviving fat volume at 6 months was 88% for the experimental group (CAL) and 54% for the control group (conventional lipoinjection) [39].…”

Section: Cosmetic Surgerymentioning

confidence: 99%

The Use of Stem Cells in Plastic and Reconstructive Surgery

Koźlik

Wójcicki

2014

Adv Clin Exp Med

View full text Add to dashboard Cite

As part of their clinical practice, plastic surgeons perform procedures in the fields of skin and adipose tissue grafting, the reconstruction of compound tissue loss and congenital malformations, the treatment of acute and chronic wounds and burns, as well as cosmetic surgery. On account of the great expectations associated with their use in therapy, stem cells (SCs) are increasingly frequently employed in in vitro experiments, animal models and clinical trials. The most commonly utilized SCs for these purposes are adult stem cells (AS), which are present in small amounts in every tissue; among these are two types of cells: bone marrow mesenchymal stem cells (BM-MSCs) and adipose-derived stem cells (ADSCs). The aim of this review is to present current findings in experimental research on the use of stem cells in the field of plastic and reconstructive surgery. Many studies have described the progress of trials using ADSCs and BM-MSCs mainly in the treatment of compound tissue loss and chronic wounds. The use of their paracrine, proangiogenic and osteogenic functions is emphasized. However, because of the very high harvesting and culturing expenses and the limited availability of data on their safety for human use, SCs are not a first-choice therapy. Further developments in SC research and gradually decreasing costs mean that along with commercial-scale SC culturing, the use of SCs will become a viable alternative to traditional surgical procedures (Adv Clin Exp Med 2014, 23, 6, 1011-1017).

show abstract

Section: Cosmetic Surgerymentioning

confidence: 99%

The Use of Stem Cells in Plastic and Reconstructive Surgery

Koźlik

Wójcicki

2014

Adv Clin Exp Med

View full text Add to dashboard Cite

show abstract

“…Chang and colleagues 23 reported a volumetric analysis of SVF-supplemented fat grafting and regular fat grafting to progressive hemifacial atrophy patients, concluding that fat survival and clinical improvement was greater with SVFsupplemented grafting than fat grafting alone after 6 months. Tanikawa and colleagues 24 reported that SVF-supplemented fat grafting for patients with craniofacial microsomia was effective. Survival fat volume was 88% at 6 months, which was significantly greater that nonsupplemented fat grafting (54%).…”

Section: Clinical Reports Of Cell-assisted Lipotransfermentioning

confidence: 98%

Condensation of Tissue and Stem Cells for Fat Grafting

Kuno

Yoshimura

2015

Clinics in Plastic Surgery

View full text Add to dashboard Cite

“…[42] Yine ya¤ kaynaklı MKH'lerin çalııldı¤ı bir baka çalımada geni keratokist nedenli hemimaksillektomi uygulanan bir hastada GMP koullarında hazırlanmı kök hücre ile trikalsiyum fosfat granüllerini titanyum mesh içinde prefabrike edilmi ve elde edilen dokunun mikrovasküler flep olarak maksillaya nakli sa¤lanmı doku biyopsilerinde yeniden ekillenen kemik varlı¤ının tespit edildi¤i bildirilmitir. [43] Tanikawa ve ark.nın [44] 2013 yılında yaptıkları klinik çalımalarında; 14 adet kraniyofasiyal mikrozomili hastaya karakterizasyonu sa¤lanmı ve canlı hücre sayısı hesaplanmı otolog YD-MKH'li ve kök hücresiz kontrol grubu olarak greft uygulanmıtır. Çalımada izolasyon sonrası CD73 ve CD105 ekspresyonları %95 olarak tespit edilirken kök hücre uygulanan gruptaki hastalarda ya¤ volümü sa¤kalımı %88, kontrol grubunda ise %54 oranında tespit edilmitir.…”

Section: Self-renewal (Kendini Yenileyebilme)unclassified

“…Çalımada izolasyon sonrası CD73 ve CD105 ekspresyonları %95 olarak tespit edilirken kök hücre uygulanan gruptaki hastalarda ya¤ volümü sa¤kalımı %88, kontrol grubunda ise %54 oranında tespit edilmitir. [44] Kardiyak hastalıklarda, MKH'lerin kullanımı, bilinen en eski kullanım alanlarından biridir. ‹skemik kalp hastalıklarında umut kayna¤ı olan MKH'ler geni randomize ve uzun dönemli klinik çalımalara ihtiyaç duymaktadır.…”

Section: Self-renewal (Kendini Yenileyebilme)unclassified

Stem cells; mesenchymal stem cells and current clinical applications

Tekeli¹

2016

FNG & Bilim Tıp Transplantasyon Dergisi

View full text Add to dashboard Cite

Stem cells are defined as a type of cell that have the features of self-renewal, unlimited proliferation capacity, potential of differentiation into other cell types and ability to repair damaged structure when given to damaged tissue. Stem cells are preferred for regenerative medical applications because of their abundance, being easily obtained, ability to proliferate by differentiating into many cell types and being transplantable safely and effectively to recipients. In this review, we introduce mesenchymal stem cells as one of the most important sources of stem cells that have clinical applications and give examples of their usage areas in the clinic and of studies.Keywords: Clinical application; mesenchymal stem cells; stem cell. Stem cells; mesenchymal stem cells and current clinical applications ÖZKök hücreler; kendilerini yenileyebilme, sınırsız çoğalabilme, kendilerinden başka hücrelere farklılaşabilme, hasarlı dokuya verildiğinde hasarlı yapıyı onarabilme özellikleri ile tanımlanan hücre tipidir. Kök hücreler bol miktarda bulunmaları, kolay elde edilebilmeleri, birçok hücre tipine farklılaşarak çoğalabilmeleri, alıcılara güvenli ve etkin bir şekilde nakledilebilmeleri nedeniyle rejeneratif tıp uygulamalarında tercih edilmektedir. Bu derlemede, klinikte uygulamaları bulunan ve en önemli kök hücre kaynaklarından biri olan mezenkimal kök hücreler tanıtılacak, klinikteki kullanım alanları ve çalışmalardan örnekler verilecektir.

show abstract

Fat Grafts Supplemented with Adipose-Derived Stromal Cells in the Rehabilitation of Patients with Craniofacial Microsomia

Abstract: Therapeutic, II.

Cited by 127 publications

References 43 publications

The Use of Stem Cells in Plastic and Reconstructive Surgery

The Use of Stem Cells in Plastic and Reconstructive Surgery

Condensation of Tissue and Stem Cells for Fat Grafting

Stem cells; mesenchymal stem cells and current clinical applications

Contact Info

Product

Resources

About