Fat Necrosis in the Breast from Methylene Blue Dye Injection

Ha, Kelli Y.; Parish, David C.; Hamilton, Raynal; Wang, Jean C.

doi:10.1080/08998280.2013.11928990

Cited by 3 publications

(3 citation statements)

References 3 publications

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“…In this study, the confidence intervals for sensitivity are wide due to a limited number of positive (“metastatic”) sites, while the confidence intervals for specificity are narrower due to a larger number of negative (“non-metastatic”) sites imaged. The percentage of resected, positive (“metastatic”) LNs in our study was originally in accordance with the national standard (less than 10 %) [ 5 , 11 , 13 ]. Toward the end of the study, however, we specifically recruited pre-operative biopsy-proven positive cases to increase our proportion of positive LNs to 22 % in an attempt to develop a more balanced statistical analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, approximately 75 % of resected nodes from all types of breast cancer are diagnosed tumor-free in post-operative permanent sections [ 10 ]. Combined with the fact that the controversial practice of delayed ALND as a second procedure after SLNB micrometastasis detection has been shown to be “oncologically meaningless in 90 % of cases” [ 9 ], it can be seen that there is an unnecessary increase of surgical cost, time and patient risk of complications, such as lymphedema and/or sensory changes due to disruption and/or obstruction of the lymphatic drainage network [ 5 , 12 , 13 ]. Lymphedema is considered the most significant concern due to the lifelong risk following surgery, because it occurs in 13–27 % of breast cancer surgery patients, and because it could be refractory to treatment [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Intraoperative optical coherence tomography for assessing human lymph nodes for metastatic cancer

et al. 2016

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BackgroundEvaluation of lymph node (LN) status is an important factor for detecting metastasis and thereby staging breast cancer. Currently utilized clinical techniques involve the surgical disruption and resection of lymphatic structure, whether nodes or axillary contents, for histological examination. While reasonably effective at detection of macrometastasis, the majority of the resected lymph nodes are histologically negative. Improvements need to be made to better detect micrometastasis, minimize or eliminate lymphatic disruption complications, and provide immediate and accurate intraoperative feedback for in vivo cancer staging to better guide surgery.MethodsWe evaluated the use of optical coherence tomography (OCT), a high-resolution, real-time, label-free imaging modality for the intraoperative assessment of human LNs for metastatic disease in patients with breast cancer. We assessed the sensitivity and specificity of double-blinded trained readers who analyzed intraoperative OCT LN images for presence of metastatic disease, using co-registered post-operative histopathology as the gold standard.ResultsOur results suggest that intraoperative OCT examination of LNs is an appropriate real-time, label-free, non-destructive alternative to frozen-section analysis, potentially offering faster interpretation and results to empower superior intraoperative decision-making.ConclusionsIntraoperative OCT has strong potential to supplement current post-operative histopathology with real-time in situ assessment of LNs to preserve both non-cancerous nodes and their lymphatic vessels, and thus reduce the associated risks and complications from surgical disruption of lymphoid structures following biopsy.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Intraoperative optical coherence tomography for assessing human lymph nodes for metastatic cancer

et al. 2016

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“…High radioactivity at the injection site can also interfere with the radioactive signal emitted by the SLN when it is located close to the tumour . The major drawbacks of blue dyes are the risks for side effects including allergic reactions, skin and fat necrosis and long‐lasting tattooing of the skin at the injection site . In addition, blue dyes can only be visualized without overlying tissue …”

Section: Introductionmentioning

confidence: 99%

Sentinel lymph node mapping by near‐infrared fluorescence imaging and contrast‐enhanced ultrasound in healthy dogs

Favril

Stock

Hernot

et al. 2018

Vet Comparative Oncology

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Sentinel lymph node (SLN) mapping is a valuable and crucial diagnostic procedure in staging malignancies. We compared two non‐invasive techniques, near‐infrared (NIR) fluorescence imaging and contrast‐enhanced ultrasound (CEUS), to identify the SLNs in three superficial anatomical regions in an animal model. Six healthy laboratory dogs were included in a proof‐of‐concept trial. A NIR fluorescent dye (Indocyanine Green) and microbubbles (Sonovue) were consecutively injected subdermally in the Inguinal, axillary and popliteal region to map the SLNs. Transcutaneous NIR fluorescence imaging identified SLNs in 17 out of a total of 18 occasions. CEUS identified SLNs in all regions (18/18). Whereas NIR fluorescence imaging performed better in the visualization of the afferent lymphatic tract, CEUS demonstrated different filling patterns of the SLNs, a feature potentially critical for the concept of SLN mapping in cancer patients. Both NIR fluorescence imaging and CEUS are safe, non‐invasive, practical and accurate methods to perform real‐time transcutaneous SLN mapping with potential in a clinical setting.

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Optimization of sentinel lymph node identification techniques in the Indian setting: A randomized clinical trial

et al. 2019

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Fat Necrosis in the Breast from Methylene Blue Dye Injection

Cited by 3 publications

References 3 publications

Intraoperative optical coherence tomography for assessing human lymph nodes for metastatic cancer

Intraoperative optical coherence tomography for assessing human lymph nodes for metastatic cancer

Sentinel lymph node mapping by near‐infrared fluorescence imaging and contrast‐enhanced ultrasound in healthy dogs

Optimization of sentinel lymph node identification techniques in the Indian setting: A randomized clinical trial

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