Fat Overload With a 10% Soybean Oil Emulsion

Belin, Robert P.

doi:10.1001/archsurg.1976.01360300081013

Cited by 48 publications

(9 citation statements)

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“…Belin et a1. 34 reported a clinical case in which lipid overload might be responsible for suddenly occurring cholestasis during TPN accompanied by hepato-splenomegaly and neurologic, cardiac, pulmonary, and renal failure. We gave group II the same lipid dose as group IV, to delete the effect of lipid.…”

Section: Discussionmentioning

confidence: 99%

A Newborn Rabbit Model for Total Parenteral Nutrition: Effects of Nutritional Components on Cholestasis

Hata¹,

Kamata²,

Nezu³

et al. 1989

J Parenter Enteral Nutr

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A newborn rabbit model for total parenteral nutrition (TPN) was developed to examine the effects of nutritional components on cholestasis. Thirty-five newborn Japanese white rabbits were divided into five groups. Rabbits in group I received glucose-based TPN solution, Group II received lipid-based solution, group III received larger amounts of amino acids than group I, and group IV received larger amounts of nonprotein calories than groups I and II. Rabbits in group V were given mother's milk freely. After the duration of TPN for 7 days, blood samples and liver were obtained when rabbits were killed. In group IV, the serum level of T-Bil (1.44 +/- 0.68 mg/dliter) was significantly higher than those in other groups (group I: 0.28 +/- 0.04 mg/dl; group II: 0.49 +/- 0.12 mg/dl; group III: 0.21 +/- 0.04 mg/dl; group V: 0.28 +/- 0.07 mg/dl), and serum level of GOT (44.2 +/- 25.2 units) and total bile acid (20.6 +/- 8.9 nmol/ml) were significantly higher than those in groups I, II, and III (group I: 16.8 +/- 7.8 units and 6.7 +/- 3.3 nmol/ml, group II: 21.5 +/- 7.9 units and 12.5 +/- 6.4 nmol/ml, group III: 14.3 +/- 4.2 units and 8.4 +/- 5.0 nmol/ml, respectively). Furthermore, there was histological cholestasis characterized by bile plugs in bile ducts, and bile pigments in Kupffer cells and hepatocytes, whereas there were no, or scarce findings of cholestasis in the other groups. These results indicate that an excessive administration of nonprotein calories in TPN contributes to the occurrence of cholestasis. In addition this animal model may be useful in investigating the etiology of cholestasis.

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Section: Discussionmentioning

confidence: 99%

A Newborn Rabbit Model for Total Parenteral Nutrition: Effects of Nutritional Components on Cholestasis

Hata¹,

Kamata²,

Nezu³

et al. 1989

J Parenter Enteral Nutr

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“…There was no evidence of infection or hypophosphataemia in our patient, which are complications of parenteral nutrition leading to haemolysis. Bone marrow examination showed marked vacuolation of myeloid and histiocytic cells which is well known in association with Intralipid over-dosage (Freund et al, 1975: Belin et al, 1976. These vacuoles did not stain with Sudan Black or Oil Red O and may therefore represent toxic changes rather than ingested fat.…”

Section: Intralipid Induced Haemolysismentioning

confidence: 73%