Fat, Protein, and Meat Consumption and Renal Cell Cancer Risk: A Pooled Analysis of 13 Prospective Studies

Lee, Jung Eun; Spiegelman, Donna; Hunter, David J.; Albanês, Demetrius; Bernstein, Leslie; Brandt, Piet den; Buring, Julie E.; Cho, Eunyoung; English, Dallas R.; Freudenheim, Jo L.; Giles, Graham G.; Graham, Saxon; Horn‐Ross, Pamela L.; Håkansson, Niclas; Leitzmann, Michael F.; Männistö, Satu; McCullough, Marjorie L.; Miller, Anthony B.; Parker, Alexander S.; Rohan, Thomas E.; Schatzkin, Arthur; Schouten, Leo J.; Sweeney, Carol; Willett, Walter C.; Wolk, Alicja; Zhang, Shumin M.; Smith‐Warner, Stephanie A.

doi:10.1093/jnci/djn386

Cited by 80 publications

(63 citation statements)

References 51 publications

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“…Several case-control studies have found protein and, in particular, animal protein to be positively associated with risk, 4,6,7,10 although 2 of these studies did not adjust for energy intake 7,10 and in 1 that did, the association with animal protein was diminished. 4 Our finding of a nonsignificant positive association with total protein and animal protein with risk of renal cell carcinoma is consistent with results from a pooled analysis of 13 prospective studies 22 and suggest that protein intake is not strongly associated with risk.…”

Section: Discussionsupporting

confidence: 83%

“…However, our findings are entirely consistent with a large multicenter case-control study 9 and a pooled analysis of prospective studies, both of which reported no association of saturated or animal fat intake with renal cell carcinoma risk after adjustment for potential confounding factors. 22 Our study is the largest study to date to examine the association between macronutrient intake and risk of renal cell carcinoma. It is of a prospective design, with approximately 9 years of followup and a wide range of macronutrient intakes between the participating countries.…”

Section: Discussionmentioning

confidence: 99%

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A prospective analysis of the association between macronutrient intake and renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition

Allen

Roddam

Sieri

et al. 2009

Intl Journal of Cancer

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Previous case‐control studies have suggested that a high intake of animal foods and its associated nutrients are associated with an increased risk of renal cell carcinoma, although data from prospective studies are limited. We report here on the relationship between macronutrient intake and renal cell carcinoma incidence among 435,293 participants enrolled in the European Prospective Investigation into Cancer and Nutrition. Cox proportional hazard models were used to examine the association of dietary intake of fat, protein, carbohydrate, fiber and cholesterol and risk of renal cell carcinoma adjusted for age, sex, center, height, body mass index, physical activity, education, smoking, menopausal status, alcohol and energy intake. During an average 8.8 years of follow‐up, 507 renal cell carcinoma cases occurred. Risk of renal cell carcinoma was not associated with macronutrient intake, including nutrients derived from animal sources. Our results indicate that macronutrient intake is not associated with risk of renal cell carcinoma in this cohort of European men and women. © 2009 UICC

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

A prospective analysis of the association between macronutrient intake and renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition

Allen

Roddam

Sieri

et al. 2009

Intl Journal of Cancer

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“…Et tüketiminin azaltılmasının genel popülasyonda böbrek kanseri insidansını azaltmasında önemli bir yaklaşım olacağı vurgulanmaktadır. Buna karşılık Lee ve arkadaşları 13 prospektif çalışmanın sonuçlarını incelediklerinde kırmızı et, işlenmiş et, kümes hayvanları ve deniz ürünlerinin tüketilmesinin BHK ile ilişkisinin olmadığı sonucuna ulaşmışlardır (33). Ayrıca büyük bir prospektif Avrupa çalışmasıda bu sonucu desteklemektedir (34).…”

Section: Beslenme Ile İlişkili Faktörlerunclassified

Böbrek Hücreli Karsinomda Risk Faktörleri ve Etyoloji

Gül¹

2014

uob

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Böbrek Hücreli Karsinom (BHK) üçüncü en sık ürolojik kanser olup daha erken evrede tanı konulmasına rağmen halen yüksek mortalite oranları ile seyretmektedir. Görülme sıklığı gittikçe artmaktadır. Etyoloji ve risk faktörlerinin daha iyi tanımlanması için yapılan epidemiyolojik çalışmalar hastalığın gelişmesini önlemede alınacak önlemler konusunda bize yeni bilgiler sunacaktır. BHK'da bilinen en güçlü risk faktörleri tütün kullanımı, obezite, ve kan basıncı yüksekliğidir. İlaç kullanımı ile BHK arasında zayıf, diyet ve mesleki faktörler ile BHK arasında ise orta derecede güce sahip ilişki ortaya konulabilmiştir. Risk faktörlerinin daha güçlü kanıtlarla ortaya konulabilmesi daha etkin tedbirlerin alınmasını sağlayacaktır. Risk altındaki insanların belirlenerek gerekli bilgilendirilmelerin yapılması ve önlemlerin alınması ile BHK gelişme riskinde azalma hedeflenebilir. (Üroonkoloji Bülteni 2014;13:135-138) Anah tar Ke li me ler: Böbrek kanseri, risk faktörleri, tütün kullanımı Renal cell carcinoma (RCC) is the third most common urological carcinoma and has the highest mortality rate although it is diagnosed at the early stage. The incidence of RCC has been increasing. Epidemiological studies conducted to better clarify the etiology and risk factors will shed new light about protective measures in prevention. The strongest known risk factors related to RCC are tobacco smoking, obesity and high blood pressure. A weak correlation was found between medications and RCC and a moderate correlation was found between occupational and dietary factors and RCC. Establishing correlations with stronger proofs between risk factors and RCC might lead to more effective preventive measures. Identification of people under risk and informing them adequately and establishing protective measures may lead to a decrease in the risk of RCC development. (Bulletin of Urooncology 2014;13:135-138)

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“…Finally, Lee and colleagues conducted a pooled analysis of 13 prospective studies that examined the associations between meat, fat, and protein intake and the risk of RCC. 71 Their pooled cohort included 530 469 females and 244 483 males who completed a validated dietary questionnaire at study entry and were followed for up to 7 to 20 years. A total of 1478 incident cases of RCC were identified.…”

Section: Effect Of Diet On Rccmentioning

confidence: 99%

Metabolic features of clear-cell renal cell carcinoma: mechanisms and clinical implications

Pinthus

Whelan

Gallino

et al. 2013

CUAJ

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Central to the malignant behaviour that endows cancer cells with growth advantage is their unique metabolism. Cancer cells can process nutrient molecules differently from normal cells and use it to overcome stress imposed on them by various therapies. This metabolic conversion is controlled by specific genetic mutations that are associated with activation of oncogenes and loss of tumour suppressor proteins. Understanding these processes is important as it can lead to the discovery of biomarkers that can predict the aggressiveness of the disease and its response to therapy, and even more importantly, to the development of novel therapeutics. A classic tumour in this respect is clear-cell renal cell carcinoma (RCC). In this review, we will begin with a brief summary of normal cellular bioenergetic pathways, which will be followed by a description of the characteristic metabolism of glucose and lipids in clear-cell RCC cells and its clinical implications. Data relating to the potential effect of dietary nutrients on RCC will also be reviewed along with potential therapies targeted at interrupting specific metabolic pathways in clear-cell RCC.

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Fat, Protein, and Meat Consumption and Renal Cell Cancer Risk: A Pooled Analysis of 13 Prospective Studies

Abstract: Intakes of fat and protein or their subtypes, red meat, processed meat, poultry, and seafood are not associated with risk of renal cell cancer.

Cited by 80 publications

References 51 publications

A prospective analysis of the association between macronutrient intake and renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition

A prospective analysis of the association between macronutrient intake and renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition

Böbrek Hücreli Karsinomda Risk Faktörleri ve Etyoloji

Metabolic features of clear-cell renal cell carcinoma: mechanisms and clinical implications

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