Fat Replacement of Paraspinal Muscles with Aging in Healthy Adults

Dahlqvist, Julia R.; Vissing, Christoffer Rasmus; Hedermann, Gitte; Thomsen, Carsten; Vissing, John

doi:10.1249/mss.0000000000001119

Cited by 84 publications

(58 citation statements)

References 30 publications

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“…Similar variations and decreases over time have been described in other neuromuscular diseases. 13 Thus, the annual increase seen in SBMA is 3 to 6 times greater than in healthy subjects. 11,12,27 Healthy subjects also have an increase in muscle fat content with age.…”

Section: Discussionmentioning

confidence: 92%

“…Some patients, however, had a great variation in muscle fat content and others had a decrease in fat content in some muscles from baseline to follow-up. We believe that these variations can be explained by changes in body mass index, physical activity, and the way a muscle is used, 13 as well as by small errors of the quantification method. 10 One of our patients DHEA-S = dehydroepiandrosterone sulfate; FSH = follicle-stimulating hormone; LH = luteinizing hormone; SD = standard deviation; SHBG = sex hormone-binding globulin.…”

Section: Discussionmentioning

confidence: 99%

“…13 The protocol for the right arm consisted of 3-planed localizers, and T1-weighted and Dixon scans of the upper arm and forearm with the following technical settings: T1-weighted images, field of view (FOV) = 200mm, slice thickness = 3.0mm, distance factor = 100%, echo time (TE) = 39 milliseconds, repetition time (TR) = 656 milliseconds; Dixon images, FOV = 245mm, slice thickness = 2.0mm, distance factor = 20%, TE = 2.45 and 3.675 milliseconds, TR = 5.64 milliseconds. The protocol included 3-planed localizers from neck to ankles, and axial T1-weighted and 2-point Dixon sequences over the lumbar spine, thighs, and calves.…”

Section: Mrimentioning

confidence: 99%

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Disease progression and outcome measures in spinobulbar muscular atrophy

Dahlqvist

Fornander

Borch

et al. 2018

Annals of Neurology

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Objective: Spinal and bulbar muscular atrophy (SBMA) is a slowly progressive disease with weakness of bulbar and extremity muscles. There is no curative treatment for the disease, but several clinical trials have been conducted over the past years. The results from these trials have uncovered a great need to develop quantitative, reliable outcome measures. In this study, we prospectively investigated disease progression over 18 months in 29 patients with genetically confirmed SBMA, using quantitative outcome measures, including Dixon magnetic resonance imaging (MRI). Methods: We used MRI to assess changes in muscle fat content and stationary dynamometry to assess changes in muscle strength. Disease progression was also investigated with the SBMA functional rating scale, bulbar rating scale, 6-minute walk test, and blood samples, among others. Results: Mean muscle fat content, muscle strength in knee extensors, handgrip strength, walking distance, and creatinine levels changed significantly. Mean muscle fat content increased by 2 ± 1.25%, and knee extension strength decreased from 83 ± 60 to 76 ± 56Nm, handgrip strength from 31 ± 13 to 29 ± 13kg, walking distance from 362 ± 216 to 336 ± 219m, and creatinine level from 58 ± 21 to 54 ± 20 μmol/l. Functional rating scores did not change.Interpretation: The present study demonstrates a slow and steady disease progression in SBMA. Dixon MRI detected increases in muscle fat content in all investigated muscles and is therefore a suitable candidate for an outcome measure in natural history or treatment studies in SBMA. The 6-minute walk test and handgrip strength also seem to be reliable outcome measures for SBMA. ANN NEUROL 2018;84:762-773 View this article online at wileyonlinelibrary.com.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Mrimentioning

confidence: 99%

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Disease progression and outcome measures in spinobulbar muscular atrophy

Dahlqvist

Fornander

Borch

et al. 2018

Annals of Neurology

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“…Both Dahlqvist et al. () and Crawford et al. (2016b) reported a different rate of compositional changes between muscles.…”

Section: Discussionmentioning

confidence: 99%

“…Dahlqvist et al. () argued that the age‐related increase in paraspinal fat infiltration did not correlate with body mass index (BMI) or physical activity, suggesting it might be a developmental phenomenon that may be difficult to modify with interventions.…”

Section: Discussionmentioning

confidence: 99%

Cross‐sectional area of lumbar spinal muscles and vertebral endplates: a secondary analysis of 91 computed tomography images of children aged 2–20

et al. 2018

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Axial muscle involvement in patients with limb girdle muscular dystrophy type R9

et al. 2022

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Introduction/Aims Limb girdle muscular dystrophy type R9 (LGMDR9) is characterized by progressive weakness of the shoulder and hip girdles. Involvement of proximal extremity muscles is well‐described whereas information about axial muscle involvement is lacking. It is important to recognize the involvement of axial muscles to understand functional challenges for the patients. The aim of this study was to investigate the involvement of axial and leg muscles in patients with LGMDR9. Methods This observational, cross‐sectional study investigated fat replacement of axial and leg muscles in 14 patients with LGMDR9 and 13 matched, healthy controls using quantitative MRI (Dixon technique). We investigated paraspinal muscles at three levels, psoas major at the lumbar level, and leg muscles in the thigh and calf. Trunk strength was assessed with stationary dynamometry and manual muscle tests. Results Patients with LGMDR9 had significantly increased fat replacement of all investigated axial muscles compared with healthy controls (P < .05). Trunk extension and flexion strength were significantly reduced in patients. Extension strength correlated negatively with mean fat fraction of paraspinal muscles. Fat fractions of all investigated leg muscles were significantly increased versus controls, with the posterior thigh muscles being the most severely affected. Discussion Patients with LGMDR9 have severe involvement of their axial muscles and correspondingly have reduced trunk extension and flexion strength. Our findings define the axial muscles as some of the most severely involved muscle groups in LGMDR9, which should be considered in the clinical management of the disorder and monitoring of disease progression.

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Fat Replacement of Paraspinal Muscles with Aging in Healthy Adults

Abstract: The paraspinal muscles were more susceptible to age-related changes than leg muscles. Further, men had significantly lower fat fractions in lumbar paraspinal muscles, and BMI was positively associated with thigh, but not paraspinal, fat fraction.

Cited by 84 publications

References 30 publications

Disease progression and outcome measures in spinobulbar muscular atrophy

Disease progression and outcome measures in spinobulbar muscular atrophy

Cross‐sectional area of lumbar spinal muscles and vertebral endplates: a secondary analysis of 91 computed tomography images of children aged 2–20

Axial muscle involvement in patients with limb girdle muscular dystrophy type R9

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