Fat-soluble vitamin and phytochemical metabolites: Production, gastrointestinal absorption, and health effects

Borel, Patrick; Dangles, Olivier; Kopec, Rachel

doi:10.1016/j.plipres.2023.101220

Cited by 11 publications

(3 citation statements)

References 297 publications

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“…26 Phase II metabolism involves conjugation reactions mediated by glucuronic, sulfate, or glutathione transferases, enhancing the water solubility of metabolites and facilitating their elimination through the kidneys into the urine. 27 However, it should be noted that a limitation of this study is the lack of analysis of specific phase I and II metabolites in this preliminary investigation. Instead, ongoing efforts are currently underway to measure these metabolites in the plasma, which will provide further insights into the metabolic pathways of KM polyphenols.…”

Section: Resultsmentioning

confidence: 86%

Bioavailability of Korean mint (Agastache rugosa) polyphenols in humans and a Caco-2 cell model: a preliminary study exploring the efficacy

Lee,

Rinik

et al. 2023

Food Funct.

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Section: Resultsmentioning

confidence: 86%

Bioavailability of Korean mint (Agastache rugosa) polyphenols in humans and a Caco-2 cell model: a preliminary study exploring the efficacy

Lee,

Rinik

et al. 2023

Food Funct.

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“…Dietary fats can also significantly affect the bioavailability of certain phytonutrients, particularly fat-soluble ones [87]. For example, carotenoids, a class of phytonutrients abundant in fruits and vegetables, are better absorbed in dietary fat [88].…”

Section: Interaction With Other Substancesmentioning

confidence: 99%

A Comprehensive Review of Phytonutrients as a Dietary Therapy for Obesity

Siddiqui,

Azmy Harahap,

Suthar

et al. 2023

Foods

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Obesity is a complex medical condition mainly caused by eating habits, genetics, lifestyle, and medicine. The present study deals with traditional diets like the Mediterranean diet, Nordic diet, African Heritage diet, Asian diet, and DASH, as these are considered to be sustainable diets for curing obesity. However, the bioavailability of phytonutrients consumed in the diet may vary, depending on several factors such as digestion and absorption of phytonutrients, interaction with other substances, cooking processes, and individual differences. Hence, several phytochemicals, like polyphenols, alkaloids, saponins, terpenoids, etc., have been investigated to assess their efficiencies and safety in the prevention and treatment of obesity. These phytochemicals have anti-obesity effects, mediated via modulation of many pathways, such as decreased lipogenesis, lipid absorption, accelerated lipolysis, energy intake, expenditure, and preadipocyte differentiation and proliferation. Owing to these anti-obesity effects, new food formulations incorporating these phytonutrients were introduced that can be beneficial in reducing the prevalence of obesity and promoting public health.

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“…Deficiency of specific fat-soluble vitamins in the body of cows is rare (Golovey et al, 2022;Borel et al, 2023;Skliarov et al, 2023). Fat-soluble vitamin and phytochemical metabolites: Production, gastrointestinal absorption, and health effects.…”

Section: Impaired Reproductive Function Due To Deficiency or Excessmentioning

confidence: 99%

Alimentary infertility in female cattle: Part ІІІ – the modulation of reproductive function with vitamins and plant derivatives (Overview)

Skliarov,

Naumenko,

Koshevoy

et al. 2023

TAVM

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Vitamins are involved in the synthesis of several organic compounds serve as coenzymes. Therefore, they are necessary for different processes such as metabolic regulation, the course of many biochemical reactions, the processes of cellular respiration, the maintenance of acidbase and electrolyte balance, and the protection of cells from oxidative stress. Thus, they support various body functions, including reproductive ones. Consequently, using diets that are not balanced in the composition of micronutrients and, in particular, vitamins can lead to several pathological conditions that affect their reproductive function and the state of the offspring. A deficiency in vitamins often results in reduced enzyme activity. Thus, specific metabolic processes are inhibited, including those in the endocrine glands associated with animal reproduction (such as the pituitary gland, adrenal glands, and ovaries), leading to disruption in the synthesis of gonadotropic and sex hormones. Delayed puberty, disruption of sexual cycles and ovulation, low fertility, and perinatal losses (impaired development and survival of embryos, early death and abortions, osteodystrophy in pregnant women, impaired development and skeletal defects in the fetus, and weak or dead offspring) are registered. Premature births occur, the contractility of the uterus and expulsion of the fetal membranes decreases, and postpartum activity is disturbed. Additionally, the period of manifestation of the first estrus after calving is prolonged, and inflammatory processes such as placentitis, cervicitis, metritis may develop. Moreover, milk fever may occur along with an increase in the frequency of cystic and atrophic ovaries. With excessive or long-term consumption of phytoestrogens, violations of the sexual cycle (from anestrus to nymphomania) can occur. Changes in the structure (cysts or their compaction) and function of the ovaries (synthesis of hormones in the follicles and corpus luteum), hyperemia of the mucous membranes, edema of the reproductive organs and post libido metrorrhagia are observed. Other effects may include prolapse of the vagina, cystic hyperplasia of the endometrium and purulent inflammation of the uterus, the onset of heat during pregnancy, a decrease in the frequency of fertilization, an increase in the loss of embryos, and the death of the fetus, difficult births, a high percentage of stillbirths. Thus, vitamins and biologically active substances of plants significantly impact the reproductive function of animals, so regulating their supply to the body of cows and heifers is an essential factor in ensuring the proper level of herd reproduction.

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Fat-soluble vitamin and phytochemical metabolites: Production, gastrointestinal absorption, and health effects

Cited by 11 publications

References 297 publications

Bioavailability of Korean mint (Agastache rugosa) polyphenols in humans and a Caco-2 cell model: a preliminary study exploring the efficacy

Bioavailability of Korean mint (Agastache rugosa) polyphenols in humans and a Caco-2 cell model: a preliminary study exploring the efficacy

A Comprehensive Review of Phytonutrients as a Dietary Therapy for Obesity

Alimentary infertility in female cattle: Part ІІІ – the modulation of reproductive function with vitamins and plant derivatives (Overview)

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