Fat‐suppressed T2 mapping of femoral cartilage in the porcine knee joint: A comparison with conventional T2 mapping

Ryu, Young Jin; Hong, Sung Hwan; Kim, Hyeonjin; Choi, Ja Young; Yoo, Hye Jin; Kang, Yusuhn; Park, Sang Joon; Kang, Heung Sik

doi:10.1002/jmri.25430

Cited by 5 publications

(7 citation statements)

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Section: Discussionmentioning

confidence: 99%

“…Previous studies [ 15 , 16 ] suggested that compared with that on conventional T2 mapping, the T2 value is reduced on in F2 T2 mapping of the knee articular cartilage. Rye et al [ 16 ] demonstrated significantly lower T2 values on FS T2 mapping than on conventional T2 mapping with porcine knees. Paakkari et al [ 15 ], similar to previous ex vivo results, demonstrated lower T2 values on FS T2 mapping than on conventional T2 mapping in healthy human volunteers.…”

Section: Discussionmentioning

confidence: 99%

“…To date, there have been a paucity of studies applying the fat suppression technique to T2 mapping as a method to overcome the chemical shift artifacts of conventional T2 mapping of knee cartilage. According to previous ex vivo and in vivo studies with a small sample of healthy volunteers [ 15 , 16 ], fat-suppressed (FS) T2 mapping helps improve reproducibility by eliminating the chemical shift artifact. Therefore, the purpose of our study is to analyze the difference between FS T2 mapping and conventional T2 mapping and the reproducibility of FS T2 mapping in the knee femoral articular cartilage.…”

Section: Introductionmentioning

confidence: 99%

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Fat-suppressed T2 mapping of human knee femoral articular cartilage: comparison with conventional T2 mapping

Kim

Yoo

Chae

et al. 2021

BMC Musculoskelet Disord

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Background There is paucity of studies applying fat suppressed (FS) technique to T2 mapping to overcome chemical shift artifacts. The purpose of the study is to difference between FS T2 and conventional T2 mapping and reproducibility of FS T2 mapping in the femoral articular cartilage. Methods Eighteen patients who had normal-looking femoral cartilage and underwent knee MRI with conventional T2 and FS T2 mapping were included. T2 values of each mapping were measured by two readers independently from nine regions in the medial femoral condyle (MFC) and lateral femoral condyle (LFC). Each anatomical region was divided by lines at ± 10°, 30°, 50°, 70°, 90°, and 110°. Comparisons of T2 values between conventional and FS T2 mapping were statistically analyzed. The T2 values between FS and conventional T2 mapping in the anterior, central and posterior femoral condyles were compared. Results The overall femoral condyle T2 values from the FS T2 map were significantly lower than those from the conventional T2 map (48.5ms vs. 51.0ms, p < 0.001). The differences in the T2 values between the two maps were significantly different among the three divisions of the LFC (p = 0.009) and MFC (p = 0.031). The intra-class correlation coefficients indicated higher agreement in the FS T2 map than in the conventional T2 map (0.943 vs. 0.872). Conclusions The T2 values of knee femoral cartilage are significantly lower on FS T2 mapping than on conventional T2 mapping. FS T2 mapping is a more reproducible method for evaluating knee femoral cartilage.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fat-suppressed T2 mapping of human knee femoral articular cartilage: comparison with conventional T2 mapping

Kim

Yoo

Chae

et al. 2021

BMC Musculoskelet Disord

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“…The T2 value of Osag T2MAP is associated with free water content in cartilage tissue. The more severe the cartilage damage, the more free water and the higher the T2 value; thus, the T2 value is an objective and reliable marker [37]. The results of Osag T2MAP and their underlying causes were similar to those of OSag-fs PD.…”

Section: Discussionmentioning

confidence: 57%

Inflammatory factors are crucial for the pathogenesis of post-traumatic osteoarthritis confirmed by a novel porcine model: “Idealized” anterior cruciate ligament reconstruction” and gait analysis

Zhao

Dong

Wei

et al. 2021

International Immunopharmacology

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Background: The study was performed to determine whether idealized anterior cruciate ligament reconstruction (IACL-R) restores normal gait features, and whether in ammatory factors are involved in the pathogenesis of post-traumatic osteoarthritis (PTOA). Methods: Fourteen mature female minipigs were allocated to a sham group (n = 7) or an IACL-R group (n = 7). Load asymmetry during gait was recorded using a pressure-sensing walkway measurement system to evaluate the gait features of the right knee joint before and after surgery. In ammatory factors (including interleukin [IL]-1α, IL-1β, IL-2, IL-6, IL-8, IL-18, tumor necrosis factor-α, and granulocytemacrophage colony-stimulating factor) in synovial uid were measured using Luminex assays before and after surgery. Cartilage integrity and the subchondral bone plate of the right knee were evaluated using histology and imaging at 3 months postoperatively.Results: Swing time and stance time returned to their preoperative values on day 31, while maximum force, contact area, peak force ,and impulse returned to their preoperative values on day 45 after the surgery in the IACL-R group (P = 0.073, 0.053, 0.107, 0.052, 0.152, and 0.059, respectively).Thus, IACL-R restored normal gait. Compared with their preoperative concentrations, all tested in ammatory factors showed signi cantly increased concentrations in the synovial uid in the IACL-R group, especially at 3, 7, and 15 days postoperatively. X-ray, computed tomography, magnetic resonance imaging, and histological data showed severe cartilage damage in the IACL-R model. Conclusion: IACL-R restored normal gait features but caused signi cant cartilage damage, indicating that signi cantly elevated in ammatory factors maybe crucial for the pathogenesis of PTOA.

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“…Using anterior-to-posterior frequency-encoding directions, the chemical shift artifact seemed to be more apparent in tibial cartilage than talar cartilage in our study. The degree of chemical shift for the segmentation, as well as calculated T1rho and T2 values, can vary depending on the cartilage orientation with respect to the magnetic field (49).…”

Section: Discussionmentioning

confidence: 99%

T1rho and T2 mapping of ankle cartilage of female and male ballet dancers

Horiuchi

Luk

et al. 2020

Acta Radiol

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Background Since ballet dancers begin their training before skeletal maturity, accurate and non-invasive identification of cartilage diseases is clinically important. Angle-dependent analysis of T1rho and T2 sequences can be useful for quantification of the composition of cartilage. Purpose To investigate the angle-dependent T1rho and T2 profiles of ankle cartilage in non-dancers and dancers. Material and Methods Ten female non-dancers, ten female dancers, and 9 male dancers were evaluated using T1rho and T2 mapping sequences. Manual segmentation of talar and tibial cartilage on these images was performed by two radiologists. Inter- and intra-rater reliabilities were calculated using intraclass correlation coefficients (ICCs) and Bland–Altman analysis. Mean thickness and volume of cartilage were estimated. Angle-dependent relaxation time profiles of talar and tibial cartilage were created. Results ICCs of the number of segmented pixels were poor to excellent. Bland–Altman plots indicated that differences were associated with segment sizes. Segmented cartilage on T1rho demonstrated larger thickness and volume than those on T2 in all populations. Male dancers showed larger cartilage thickness and volume than female dancers and non-dancers. Each cartilage demonstrated angular-dependent T1rho and T2 profiles. Minimal T1rho and T2 values were observed at approximately 180°–200°; higher values were seen at the angle closer to the magic angle. Minimal T2 value of talar cartilage of dancers was larger than that of non-dancers. Conclusion In this small cohort study, regional and sex variations of ankle cartilage T1rho and T2 values in dancers and non-dancers were demonstrated using an angle-dependent approach.

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Fat‐suppressed T₂ mapping of femoral cartilage in the porcine knee joint: A comparison with conventional T₂ mapping

Abstract: 2 J. Magn. Reson. Imaging 2017;45:1076-1081.

Cited by 5 publications

References 28 publications

Fat-suppressed T2 mapping of human knee femoral articular cartilage: comparison with conventional T2 mapping

Fat-suppressed T2 mapping of human knee femoral articular cartilage: comparison with conventional T2 mapping

Inflammatory factors are crucial for the pathogenesis of post-traumatic osteoarthritis confirmed by a novel porcine model: “Idealized” anterior cruciate ligament reconstruction” and gait analysis

T1rho and T2 mapping of ankle cartilage of female and male ballet dancers

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