Fat-suppressed three-dimensional spoiled gradient-echo MR imaging of hyaline cartilage defects in the knee: comparison with standard MR imaging and arthroscopy.

Disler, David G.; McCauley, Thomas R.; Kelman, Chad G.; Fuchs, Marc D.; Ratner, L M; Wirth, Carl R.; Hospodar, Paul P.

doi:10.2214/ajr.167.1.8659356

Cited by 396 publications

(271 citation statements)

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“…Grade I lesions were excluded as a result of the difficulties in differentiating these lesions from normal (ICRS Grade 0) cartilage by MRI [9]. Because previous studies have shown MRI is unreliable in detecting superficial lesions (softening) [13,16,27], only Graded II to IV lesions were documented to avoid false-positive MRI findings. ICRS Grade II describes articular cartilage defects extending down to less than 50% of cartilage depth, Grade III extending deeper than 50% of cartilage depth, and Grade IV are defects with full-thickness articular cartilage loss.…”

Section: Methodsmentioning

confidence: 99%

Ligament Reconstruction versus Distal Realignment for Patellar Dislocation

Sillanpää

Mattila

Visuri

et al. 2008

Clinical Orthopaedics &Amp; Related Research

108

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Section: Methodsmentioning

confidence: 99%

Ligament Reconstruction versus Distal Realignment for Patellar Dislocation

Sillanpää

Mattila

Visuri

et al. 2008

Clinical Orthopaedics &Amp; Related Research

108

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“…MR sequences used for semiquantitative scoring of cartilage lesions involve T 1 -weighted spoiled gradient recalled acquisition at steady state (SPGR ¼ spoiled gradient echo or FLASH ¼ fast low-angle shot) with fat suppression (38,(40)(41)(42)(43)(44)(45)(46)(47) the internal structure of the cartilage displays a more heterogeneous signal and 'internal' pathological changes may be more readily displayed. Also, cartilage surface lesions are well depicted with these sequences, because of the steep gradient of signal intensity between the cartilage and the synovial fluid, in particular when effusion is present [ Fig.…”

Section: Semiquantitative Scoring Of Articular Tissues In Oa Hardwarementioning

confidence: 99%

“…Satisfactory specificity and sensitivity for detecting chondral lesions has been demonstrated in cadaveric knees and in vivo with arthroscopic verification (40)(41)(42)(48)(49)(50)53). Bredella et al (51) reported a sensitivity of 93% and a specificity of 99% in detecting chondral lesions versus athroscopy when axial and coronal images were combined, and values of 94/99% when images in all three planes were combined.…”

Section: Technical Accuracy and Precision Of Measurementsmentioning

confidence: 99%

“…MR sequences used for semiquantitative scoring of cartilage lesions involve T 1 -weighted spoiled gradient recalled acquisition at steady state (SPGR ¼ spoiled gradient echo or FLASH ¼ fast low-angle shot) with fat suppression (38,(40)(41)(42)(43)(44)(45)(46)(47) or selective water excitation (we) (48) [Figs 1, 2 and 3(a)], fat-suppressed T 2 -or intermediate (IM) weighted fast spin-echo (FSE) (38,43,(49)(50)(51)(52) [ Fig. 3(b) and (c)] and fat-suppressed driven equilibrium Fourier transform (DEFT) imaging (53).…”

Section: Semiquantitative Scoring Of Articular Tissues In Oa Hardwarementioning

confidence: 99%

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Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis

2006

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Magnetic resonance imaging (MRI) and quantitative image analysis technology has recently started to generate a great wealth of quantitative information on articular cartilage and bone physiology, pathophysiology and degenerative changes in osteoarthritis. This paper reviews semiquantitative scoring of changes of articular tissues (e.g. WORMS ¼ whole-organ MRI scoring or KOSS ¼ knee osteoarthritis scoring system), quantification of cartilage morphology (e.g. volume and thickness), quantitative measurements of cartilage composition (e.g. T 2 , T 1rho , T 1Gd ¼ dGEMRIC index) and quantitative measurement of bone structure (e.g. app. BV/TV, app. TbTh, app. Tb.N, app. Tb.Sp) in osteoarthritis. For each of these fields we describe the hardware and MRI sequences available, the image analysis systems and techniques used to derive semiquantitative and quantitative parameters, the technical accuracy and precision of the measurements reported to date and current results from cross-sectional and longitudinal studies in osteoarthritis. Moreover, the paper summarizes studies that have compared MRI-based measurements with radiography and discusses future perspectives of quantitative MRI in osteoarthritis. In summary, the above methodologies show great promise for elucidating the pathophysiology of various tissues and identifying risk factors of osteoarthritis, for developing structure modifying drugs (DMOADs) and for combating osteoarthritis with new and better therapy. Copyright # 2006 John Wiley & Sons, Ltd.KEYWORDS: osteoarthritis; joint; cartilage; bone; magnetic resonance imaging; knee; image analysis; disease-modifying drugs RATIONALE FOR QUANTITATIVE MRI OF CARTILAGE AND BONE IN OSTEOARTHRITISThe health and integrity of diarthrodial (synovial) joints are prerequisites for pain-free movement and have a major impact on the quality of life. However, the population of individuals above the age of 65 years is rapidly growing and 70% of the women and 60% of the men aged 65 years or older suffer from degenerative joint disease [¼ osteoarthritis (OA)] (1-7). OA has been defined by the American College of Rheumatology (ACR) as a 'heterogeneous group of conditions that leads to joint symptoms and signs which are associated with defective integrity of articular cartilage, in addition to related changes in the underlying bone at the joint margins'. It remains an open question whether the initial changes take place in cartilage or bone or other articular tissues and, more importantly, what the causal relationship between these changes is (5-19). Also, within each NMR IN BIOMEDICINE NMR Biomed. 2006; 19: 822-854 Published online in Wiley InterScience (www.interscience.wiley.com). DOI:10.1002/nbm.1063 narrowing; JSW, joint space width; K, knee; KLG, Kellgren Lawrence grade; KOSS, knee osteoarthritis scoring system; LF, lateral femoral condyle; LT, lateral tibia; MRI, magnetic resonance imaging; MF, medial femoral condyle; MT, medial tibia; OA, osteoarthritis; OAI, Osteoarthritis Initiative; P, patella; PGs, proteoglycans;...

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“…It is nonionizing, offers multiplanar capabilities, has high spatial resolution, and provides superior depiction of soft tissue detail. In addition to evaluation of articular cartilage volume, thickness, and degeneration (9)(10)(11)(12)(13)(14), recent advances have made it possible to use MRI to assess bony and soft tissue changes. In a guinea pig model, results showed that MR images of trabecular bone accurately reflected the degree of osteopenia and the development of subchondral sclerosis and osteophytes (15).…”

mentioning

confidence: 99%

Magnetic resonance imaging of normal and osteoarthritic trabecular bone structure in the human knee

Beuf¹,

Ghosh²,

Newitt³

et al. 2002

Arthritis & Rheumatism

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Objective. To use high-resolution magnetic resonance imaging (MRI) to evaluate the trabecular bone structure in the distal femur and the proximal tibia and its to correlate the findings with different stages of osteoarthritis (OA) of the human knee.Methods. Axial images of the distal femur and proximal tibia were obtained at 1.5 T in patients without and with mild OA and with severe OA. The spatial resolution was 195 ؋ 195 m 2 with a 1-mm slice thickness. Apparent measures of trabecular bone volume fraction (BV/TV), trabecular number (Tb.N), trabecular separation (Tb.Sp), and trabecular thickness (Tb.Th) were calculated.Results. Significant differences existed in the trabecular bone structure of the femur and tibia. Differences in trabecular bone structure between the tibia and the femur decreased with the degree of OA. The apparent BV/TV, Tb.N, and Tb.Sp in the femoral condyles could be used to differentiate healthy patients or patients with mild OA from patients with severe OA (P < 0.05). Among individuals, the structural variation of the lateral and medial femoral condyle was indicative of the extent of the disease.Conclusion. High-resolution MRI of the knee joint can provide a noninvasive assessment of trabecular bone structure. Trabecular bone structure, determined by high-resolution MRI, shows significant variation in patients with varying degrees of OA. The impact of OA on trabecular bone is different in the tibia than in the femur, and this difference depends on the extent of the disease.Osteoarthritis (OA) is a multifactorial disease characterized by the progressive loss of articular hyaline cartilage and the development of altered joint congruency, subchondral sclerosis, intraosseous cysts, and osteophytes. It affects about 14% of the adult population (1) and is the second most common cause of permanent disability among subjects over the age of 50 years (2). In addition to changes in articular cartilage that occur in OA, it has been suggested that early changes are seen in the adjoining subchondral and trabecular bone (3).In a guinea pig model, Layton et al (4) observed with microscopic computed tomography (CT) that an initial loss of trabecular bone volume fraction and thinning of trabeculae was followed, in the advanced stages of OA, by an increase of trabecular bone volume fraction via eventual thickening of trabeculae. In a canine OA model induced by anterior cruciate ligament (ACL) transection, Dedrick et al (5) demonstrated an increase in subchondral bone thickness, accompanied by a decrease in trabecular thickness. Using magnification radiographs of humans, Lynch et al (6) showed an increase in the horizontal trabecular thickness of the tibia in early OA, followed by an increase in vertical connectivity of trabeculae in advanced disease. More recently, Buckland-Wright and colleagues (7) showed that the structural changes in the trabecular bone microarchitecture in patients with ACL ruptures are detectable by fractal analysis of radiographs, well before joint space narrowing and other radiologic ...

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Fat-suppressed three-dimensional spoiled gradient-echo MR imaging of hyaline cartilage defects in the knee: comparison with standard MR imaging and arthroscopy.

Cited by 396 publications

References 25 publications

Ligament Reconstruction versus Distal Realignment for Patellar Dislocation

Ligament Reconstruction versus Distal Realignment for Patellar Dislocation

Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis

Magnetic resonance imaging of normal and osteoarthritic trabecular bone structure in the human knee

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