Fat tissue histological study at NIR laser treatment of the skin in vivo

Yanina, Irina Yu.; Tuchin, Valery V.; Navolokin, Nikita; Матвеева, О. В.; Bucharskaya, Alla B.; Maslyakova, Galina N.

doi:10.1117/12.889178

Cited by 3 publications

(7 citation statements)

References 32 publications

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“…Earlier we demonstrated that the combined action of ICG and NIR laser radiation (808 nm) may cause the development of pronounced morphological changes in tissues [33]. It was previously shown that that the dye accumulates in the intercellular space [32,75,76]. In this study, we used ICG dissolved in saline to reduce some negative effect of necrosis on the upper layers of the skin.…”

Section: Discussionmentioning

confidence: 99%

“…The use of these terms reflects the specificity of biochemical and morphological approaches [30,31]. Depending on technology applied, cell apoptosis or necrosis may take place [32]. Another method of fat tissue destruction, namely photodynamic/photothermal method, may provide reduction of regional or site-specific accumulations of adipose tissue least-invasively [32][33][34].…”

Section: Introductionmentioning

confidence: 99%

“…Depending on technology applied, cell apoptosis or necrosis may take place [32]. Another method of fat tissue destruction, namely photodynamic/photothermal method, may provide reduction of regional or site-specific accumulations of adipose tissue least-invasively [32][33][34]. Table 1 briefly summarizes the major features of photodynamic and photothermal treatments, as well as photobiomodulation action, which may accompany these treatments [35][36][37][38][39][40][41][42][43][44].…”

Section: Introductionmentioning

confidence: 99%

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Skin and subcutaneous fat morphology alterations under the LED or laser treatment in rats in vivo

Yanina

Navolokin

Bucharskaya

et al. 2019

Journal of Biophotonics

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The main objective of this work is to quantify the impact of photodynamic/photothermal treatment by using visible LED and NIR laser irradiation through the skin of subcutaneous fat in vivo followed up by tissue sampling and histology. The optical method may provide reduction of regional or site‐specific accumulations of abdominal or subcutaneous adipose tissue precisely and least‐invasively by inducing cell apoptosis and controlled necrosis of fat tissue. As photodynamic/photothermal adipose tissue sensitizers Brilliant Green (BG) or Indocyanine Green (ICG) dyes were injected subcutaneously in rats. The CW LED device (625 nm) or CW diode laser (808 nm) were used as light sources, respectively. Biopsies of skin together with subcutaneous tissues were taken for histology. The combined action BG‐staining and LED‐irradiation (BG + LED) or ICG‐staining and NIR‐laser irradiation (ICG + NIR) causes pronounced signs of damage of adipose tissue characterized by a strong stretching, thinning, folding and undulating of cell membranes and appearance of necrotic areas. As a posttreatment after 14 days only connective tissue was observed at the site of necrotic areas. The data obtained are important for safe light treatment of site‐specific fat accumulations, including cellulite. This work provides a basis for the development of fat lipolysis technologies and to move them to clinical applications. Schematics of animal experiment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Skin and subcutaneous fat morphology alterations under the LED or laser treatment in rats in vivo

Yanina

Navolokin

Bucharskaya

et al. 2019

Journal of Biophotonics

Self Cite

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“…Abdominal fat causes cerebrovascular disease [2]. The laser irradiation method of reducing abdominal fat can thermally decompose fat through the selective irradiation of adipose tissue [3]. The laser has a narrow bandwidth, and the beam is a straight path of light [4].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, intensive irradiation enables localized thermal decomposition of adipose tissue. However, the intense heat causes side effects, such as trauma, bleeding, burns, and pain [3]. In addition, lasers are expensive and have a high-power consumption.…”

Section: Introductionmentioning

confidence: 99%

NIR Irradiation Based on Low-Power LED Drive Module Design for Fat Reduction

Yoon

Kim

2021

BioMed Research International

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In this study, we designed a low-power visible ray (V) drive module based on a light-emitting diode (LED) to initiate fat reduction using light source irradiation. A chemical phantom of muscle and fat was fabricated, and the performance of the proposed LED drive module was tested using this chemical phantom. The LED light source could reduce fat by irradiating the skin 4–5 cm deep. The device exhibits a negative feedback and parallel amplification to maintain a stable circuit based on low-power consumption. Muscles have a high-water content and low impedance, whereas fats have a low water content and significant salt content. Therefore, fat exhibits high impedance. Chemical phantoms were fabricated according to these impedance values, and the fat reduction effect using the LED circuits was analyzed. When the fat phantom was irradiated by the light source, the fat impedance lowered, and we confirmed that fat reduction could be obtained. This study is expected to be applicable to family medicine and weight management health care.

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Effects of Near Infrared light Application Combined with Aerobic Exercise on Excessive Abdominal Fat and Obesity

Ali¹,

Ryu²,

Kim³

et al. 2013

IJAST

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This study was conducted to examine the effects of a near infrared-light-emitting diode (NIR-LED) in conjunction with low endurance exercise on obesity and abdominal fat. Twenty-six overweight adolescents aged 14-15 years were divided into an experimental and control group. Participants in the experimental group performed endurance exercise on a treadmill while wearing NIR-LED belts on their abdomens. The exercise intensity, duration, and frequency were 50% VO2 max, 45 min/session and three days per week for four weeks. Participants in the control group underwent the same exercise protocol as those in the experimental group. The only difference between both groups was that the participants in the control group used belts that have no NIR-LED. The results of this experiment demonstrated that participants in the experimental group showed a significantly reduced body mass index (BMI), circumference of waists, and percentage of body fat when compared to participants in the control group. These results suggest that application of the NIR-LED is an effective method for the treatment of obesity and reducing abdominal fat. We postulated that NIR stimulated the biological functions of cells situated at the abdominal region, which made more fat available for burning during endurance exercise. In addition, NIR-LED and exercise increased body temperature during treatment, which further enhanced mobilization of fatty tissues. These underlying mechanisms support the view that both NIR and low intensity exercise show synergistic effects for reducing fat. However, further research is needed to validate the results presented herein.

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Fat tissue histological study at NIR laser treatment of the skin in vivo

Cited by 3 publications

References 32 publications

Skin and subcutaneous fat morphology alterations under the LED or laser treatment in rats in vivo

Skin and subcutaneous fat morphology alterations under the LED or laser treatment in rats in vivo

NIR Irradiation Based on Low-Power LED Drive Module Design for Fat Reduction

Effects of Near Infrared light Application Combined with Aerobic Exercise on Excessive Abdominal Fat and Obesity

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