Fat-to-Muscle Ratio Is Independently Associated with Hyperuricemia and a Reduced Estimated Glomerular Filtration Rate in Chinese Adults: The China National Health Survey

Abstract

Background: The effects of the fat-to-muscle ratio (FMR) on hyperuricemia and a reduction in the estimated glomerular filtration rate (eGFR) are still unclear. Methods: Data from the China National Health Survey were used to explore the associations of the FMR with hyperuricemia and reduced eGFR. The fat mass and muscle mass were measured through bioelectrical impedance analysis. Mediation analysis was used to estimate the mediated effect of hyperuricemia on the association between the FMR and reduced eGFR. Results: A total of 31171 participants were included. For hyperuricemia, compared with the Q1 of the FMR, the ORs (95% CI) of Q2, Q3 and Q4 were 1.60 (1.32–1.95), 2.31 (1.91–2.80) and 2.71 (2.15–3.43) in men and 1.91 (1.56–2.34), 2.67 (2.12–3.36) and 4.47 (3.40–5.89) in women. For the reduced eGFR, the ORs (95% CI) of Q2, Q3 and Q4 of the FMR were 1.48 (1.18–1.87), 1.38 (1.05–1.82) and 1.45 (1.04–2.04) in men aged 40–59, but no positive association was found in younger men or in women. Hyperuricemia mediated the association between the FMR and reduced eGFR in men. The OR (95% CI) of the indirect effect was 1.08 (1.05–1.10), accounting for 35.11% of the total effect. Conclusions: The FMR was associated with hyperuricemia and reduced eGFR, and the associations varied based on sex and age. The effect of the FMR on the reduced eGFR was significantly mediated by hyperuricemia in men.

The development and validation of a non-invasive prediction model of hyperuricemia based on modifiable risk factors: baseline findings of a health examination population cohort

“…Modifiable risk factors of HUA, such as excess body weight, dairy products, purine-rich food intake, alcohol consumption, sleep duration, etc . 6,15,19,20 have particular importance in disease prevention and control given their changeable levels and thereafter resulting in potential health benefits. Shi et al developed a prediction model of HUA that contains no invasive tests as predictors, in which BMI was selected as a modifiable risk factor.…”

“…14 Hyperuricemia was defined as a SUA higher than 360 μmol L −1 (approximately 6 mg dl −1 ) in women and 420 μmol L −1 (approximately 7.0 mg dl −1 ) in men, or current use of uric acid lowering drugs. 5,15 Data pre-processing…”

“…Modifiable risk factors of HUA, such as excess body weight, dairy products, purine-rich food intake, alcohol consumption, sleep duration, etc. 6,15,19,20 have particular importance in disease prevention and control given their changeable levels developed a prediction model of HUA that contains no invasive tests as predictors, in which BMI was selected as a modifiable risk factor. 21 In addition to the well-known risk factors of HUA, such as overweight/obesity, alcohol consumption, our study found that staying up late was commonly associated with a higher risk of HUA, which is in line with other previous studies.…”

Occupational Risk Factors for Physical and Mental Health in Primary Healthcare Providers: A National Cross-Sectional Survey from 62 Urban Communities in China

“…Overweight and obesity were defined as 24 ≤ BMI < 28 kg/m 2 , and BMI ≥ 28 kg/m 2 , according to the classification criteria for Chinese people. 15 , 16 …”

“…Overweight and obesity were defined as 24 ≤ BMI < 28 kg/m 2 , and BMI ≥ 28 kg/m 2 , according to the classification criteria for Chinese people. 15,16 Occupational information was collected, including the rank of profession title (none/primary/medium/senior), professional areas (doctor, nurse, pharmacist/administration/others), fatigue level, perceived stress, intention-to-leave the jobs, etc. In addition, information on workloads related to COVID-19 prevention and control was collected.…”