FAT4 hypermethylation and grade dependent downregulation in gastric adenocarcinoma

Langroudi, Maryam Pilehchian; Nikbakhsh, Novin; Samadani, Ali Akbar; Fattahi, Sadegh; Taheri, Hassan; Shafaei, Shahryar; Amirbozorgi, Galia; Langroudi, Reza Pilehchian; Akhavan‐Niaki, Haleh

doi:10.1007/s12079-016-0355-5

Cited by 25 publications

(15 citation statements)

References 35 publications

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“…These cell adhesion molecules interact in a heterophilic manner to initiate bidirectional signaling (hereafter Fat signaling), mediated by their cytoplasmic domains to regulate a number of critical developmental processes including growth, tissue patterning, convergent extension and directed cell migration. Mutations in FAT4 and DCHS1 are associated with many cancers and multi system developmental defects such as Van Maldergem syndrome and Hennekam syndrome, characterized by craniofacial anomalies, intellectual dysfunction, digital contractures, hypoplastic kidneys, sternal and auditory defects ( Cappello et al, 2013 ; Alders et al, 2014 ; Hou et al, 2016 ; Ma et al, 2016 ; Pilehchian Langroudi et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Emerging Mechanisms of Growth and Patterning Regulation by Dachsous and Fat Protocadherins

Gridnev

Misra

2022

Front. Cell Dev. Biol.

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Dachsous (Ds) and Fat are evolutionarily conserved cell adhesion molecules that play a critical role in development of multiple organ systems, where they coordinate tissue growth and morphogenesis. Much of our understanding of Ds-Fat signaling pathway comes from studies in Drosophila, where they initiate a signaling pathway that regulate growth by influencing Hippo signaling and morphogenesis by regulating Planar Cell Polarity (PCP). In this review, we discuss recent advances in our understanding of the mechanisms by which Ds-Fat signaling pathway regulates these critical developmental processes. Further, we discuss the progress in our understanding about how they function in mammals.

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Section: Introductionmentioning

confidence: 99%

Emerging Mechanisms of Growth and Patterning Regulation by Dachsous and Fat Protocadherins

Gridnev

Misra

2022

Front. Cell Dev. Biol.

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“…In particular, TGFβ1 molecule produced by stromal cells can impart an important role in regulating microenvironmental bystander effects. [65][66][67][68][69] The role of this molecule in three processes of maintaining tissue stability, responding to radiation, and developing bystander effect further confirms a link between the bystander effect and the microenvironmental response to radiation.…”

Section: Radiation Microenvironment and Carcinogenesismentioning

confidence: 67%

The Role of Ionizing Radiation in Cellular Signaling Pathways, Mutagenesis, and Carcinogenesis

rezaiekahkhaie

Keikhaie

2019

Int J Basic Sci Med

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One of the negative effects of ionizing radiation is the alteration of cellular signaling pathways which lead to carcinogenesis and tumorigenesis. In this review, we discussed the impacts of ionizing radiation on cells and cellular signaling pathways. In this regard, exposure to radiation can directly or indirectly alter cellular signaling pathways. Remarkably, irradiated cells release special mediators into cellular matrix, aberrating cell-cell and cell-environment interactions. Most notably, these mediators include nitric oxide (NO), reactive oxygen species (ROS), and cell growth factors which contribute to cellular interactions between irradiated cells and their neighbor cells, a phenomenon known as radiation-induced bystander effect. DNA molecule is the most important cellular compartment damaged by ionizing radiation. On the other hand, the ability of irradiated cells to repair the damaged DNA is very low. Therefore, DNA alternations are passed to the next generations, and ultimately lead to carcinogenesis. The study of ionizing radiations and their impacts on biological systems is of remarkable importance to divulge their impacts on cellular signaling pathways.

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“…Through Gene Expression Analysis, we speculated that FAT4 was a tumor suppressor gene. Studies suggested FAT4 expression was reduced in gastric adenocarcinoma and hepatocellular carcinoma tumor tissues, and FAT4 downregulation was associated with tumor grade ( 11 , 12 ). Functional analysis using RNAi-mediated knockdown of FAT4 revealed an increased cancer cell growth and proliferation, suggesting the putative tumor suppressor role of FAT4 in hepatocellular carcinoma cancer ( 12 ).…”

Section: Discussionmentioning

confidence: 99%

A pan-cancer analysis of FAT atypical cadherin 4 (FAT4) in human tumors

Mao

Zhou

et al. 2022

Front. Public Health

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ObjectiveWe performed a pan-cancer analysis to explore the potential mechanisms of FAT4 in 33 different tumors.MethodsIn this study, we selected 33 types of cancers based on the datasets of TCGA (the cancer genome atlas). We analyzed the expression of FAT4 in tumor and normal tissues. Meanwhile, we analyzed the expression levels of FAT4 in tissues from tumors of different stages. Kaplan-Meier survival analysis, Tumor Mutational Burden (TMB), Microsatellite Instability (MSI), immune infiltration analysis, Gene set enrichment analysis (GSEA), and FAT4-related gene enrichment analysis were performed.ResultsFAT4 expression in most tumor tissues was lower than in corresponding control tissues. FAT4 expression was different in different stages of bladder cancer (BLCA), kidney clear cell carcinoma (KIRC), and breast cancer (BRCA). In addition, the expression level of FAT4 in different types of tumors has an important impact on the prognosis of patients. FAT4 might influence the efficacy of immunotherapy via tumor burden and microsatellite instability. We observed a statistically positive correlation between cancer-associated fibroblasts and FAT4 expression in most tumors. GSEA of BLCA indicated that low FAT4 expression groups were mainly enriched in calcium signaling pathway and chemokine signaling pathway. GSEA analysis of KIRC suggested low FAT4 expression groups were mainly involved in olfactory transduction and oxidative phosphorylation. Kyoto Encyclopedia of Genes and Genomes (KEGG) indicated that the role of FAT4 in the pathogenesis of cancer may be related to human papillomavirus infection, Hippo signaling pathway, PI3K–Akt signaling pathway, etc. Gene Ontology (GO) enrichment analysis further showed that most of these genes were related to the pathways or cell biology, such as peptidyl–tyrosine phosphorylation, cell junction assembly, protein tyrosine kinase activity, etc.ConclusionOur study summarized and analyzed the antitumor effect of FAT4 in different tumors comprehensively, which aided in understanding the role of FAT4 in tumorigenesis from the perspective of clinical tumor samples. Pan-cancer analysis showed that FAT4 to be novel biomarkers for various cancers prognosis.

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FAT4 hypermethylation and grade dependent downregulation in gastric adenocarcinoma

Cited by 25 publications

References 35 publications

Emerging Mechanisms of Growth and Patterning Regulation by Dachsous and Fat Protocadherins

Emerging Mechanisms of Growth and Patterning Regulation by Dachsous and Fat Protocadherins

The Role of Ionizing Radiation in Cellular Signaling Pathways, Mutagenesis, and Carcinogenesis

A pan-cancer analysis of FAT atypical cadherin 4 (FAT4) in human tumors

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