Fatal acute myocarditis and fulminant hepatic failure in an infant with pandemic human influenza A, H1N1 (2009) virus infection

El-Shabrawi, Mortada; Bazaraa, Hafez; Zekri, Hanan; Rady, Hanaa Ibrahim

doi:10.1016/j.jare.2011.01.003

Cited by 5 publications

(6 citation statements)

References 5 publications

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“…Carrillo-Esper et al, in 2010, reported two adult H1N1 patients with hepatic involvement 1. El-Shabrawi et al, in 2011, reported a 10-month-old child with acute myocarditis and fulminant hepatic failure associated with H1N1 6. The subject of the current case report had acute hepatic failure that presented as jaundice, elevated liver enzymes, and coagulopathy.…”

Section: Discussionmentioning

confidence: 64%

“… 1 El-Shabrawi et al, in 2011, reported a 10-month-old child with acute myocarditis and fulminant hepatic failure associated with H1N1. 6 The subject of the current case report had acute hepatic failure that presented as jaundice, elevated liver enzymes, and coagulopathy. Most of the other causes of liver failure had been ruled out by relevant investigations.…”

Section: Discussionmentioning

confidence: 88%

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Acute hepatic failure in pediatric H1N1 infection: a case report from Al-Adan Hospital, Kuwait

Al-Refaee

2012

HMER

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Liver involvement in pediatric influenza A (H1N1) infection is rare. Focused clinical evaluation and laboratory tests can rule out or identify hepatic complications early on. Here we report on a 9-year-old boy treated by the Gastroenterology, Hepatology, and Nutrition Unit of Al-Adan Hospital’s Pediatric Department. The patient, who was infected with H1N1 during the 2010 pandemic, showed symptoms of associated acute hepatic failure, was managed conservatively, and recovered completely following treatment. The author would like to draw the attention of pediatricians to the hepatic aspect of human H1N1 infection in order for them to recognize it early and treat it in a timely manner.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 88%

Acute hepatic failure in pediatric H1N1 infection: a case report from Al-Adan Hospital, Kuwait

Al-Refaee

2012

HMER

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Section: Discussionmentioning

confidence: 99%

“…Extrapulmonary involvement is extremely rare for influenza viruses, which may present as severe gastrointestinal complications, such as pancreatitis, hemorrhagic gastritis, and Reye's syndrome, and influenza-associated myocarditis and pericarditis. [3][4][5] Influenza A H3N2 is associated with increased mortality in pediatric patients with underlying diseases, age less than 5 years (especially <6 months), and coinfections with Staphylococcus aureus or Streptococcus pneumonia. 6 Even though underlying diseases have been implicated as a cause of increased mortality, 40% of influenza-related deaths in children have been shown to have no association with such conditions.…”

Section: Discussionmentioning

confidence: 99%

A child with acute liver failure associated with influenza A and resolved with plasma exchange treatment

Yükselmiş

Girit

Çağ

et al. 2018

Hong Kong Journal of Emergency Medicine

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Introduction: Although liver support systems play a major role as a bridge to transplantation, they may sometimes serve as a lifesaving treatment eliminating this need. Case presentation: We report on a 4-year-old boy who developed acute liver failure due to an influenza A (H3N2) infection as confirmed by clinical and laboratory data (molecular typing, stage 3 encephalopathy, brain edema, increased levels of ammonia, bilirubin, and international normalized ratio 5.2). Testing for any possible underlying liver disease showed no congenital or acquired liver pathology. Oral oseltamivir treatment was initiated and liver support therapy with plasma exchange was performed as a bridge to transplantation. A total of three plasma exchange sessions every other day, with fresh frozen plasma 1.5 times the total blood volume for the first course and 1 times for the subsequent courses, were performed. After the first plasma exchange, encephalopathy improved to stage 2, accompanied by substantial decreases in the elevated liver function tests. At the end of three plasma exchange sessions, the patient's clinical condition improved significantly. At 14 days after admission, deep tendon reflexes of the patient were normal and levels of alanine transaminase, aspartate transaminase, bilirubin, ammonia, and international normalized ratio returned to normal. Liver support treatment with plasma exchange resulted in complete recovery and the patient was discharged on the 17th day of admission. Conclusion: Acute supportive treatment with plasma exchange proved to be life-saving in our case.

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“…El-Shabrawi et al8 published a case of acute myocarditis and fulminant hepatic failure in an infant with pandemic human influenza A, H1N1 in a 10-month-old child; while Sánchez-Torrent et al9 described a 3-month-old infant with H1N1 encephalitis.…”

Section: Discussionmentioning

confidence: 99%

Alteration of liver function due to H1N1 infection: a case report

Alhammadi¹,

Hendaus²,

Kayoum³

2013

CEG

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H1N1 virus is known to affect the respiratory tract. The majority of healthcare providers focus on the respiratory complications attributed to H1N1 infection, overlooking possible multi-organ involvement. We present a rare case of abnormal liver function in a child who was admitted for respiratory illness due to the H1N1 virus. There was a marked elevation in liver function tests concurrent with the respiratory disease. Our patient was treated with oseltamavir for the H1N1 infection, and the liver function levels decreased dramatically in 72 hours.

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Fatal acute myocarditis and fulminant hepatic failure in an infant with pandemic human influenza A, H1N1 (2009) virus infection

Cited by 5 publications

References 5 publications

Acute hepatic failure in pediatric H1N1 infection: a case report from Al-Adan Hospital, Kuwait

Acute hepatic failure in pediatric H1N1 infection: a case report from Al-Adan Hospital, Kuwait

A child with acute liver failure associated with influenza A and resolved with plasma exchange treatment

Alteration of liver function due to H1N1 infection: a case report

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