Fatal adverse drug events: the paradox of drug treatment

Buajordet, Ingebjørg; Ebbesen, Just; Erikssen, Jan; Brørs, Odd; Hilberg, Thor

doi:10.1111/j.1365-2796.2001.00892.x

Cited by 56 publications

(34 citation statements)

References 38 publications

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“…[1][2][3][4][5] ADRs cause premature deaths in older people, both in hospitals, 6 and in the community. 7 The economic burden of ADRs is considerable.…”

Section: Introductionmentioning

confidence: 99%

Prescription peer academic detailing to reduce inappropriate prescribing for older patients: a cluster randomised controlled trial

Rognstad¹,

Brekke²,

Fetveit³

et al. 2013

Br J Gen Pract

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BackgroundOlder patients are at particular risk for adverse drug reactions. In older people, interventions targeting potentially inappropriate prescriptions (PIPs) are considered important measures to minimise drug-related harm, especially in the general practice setting where most prescriptions for older patients are issued. AimTo study the effects of a multifaceted educational intervention on GPs' PIPs for older patients. Design and settingThis was a cluster randomised, educational intervention study in Norwegian general practice. Pre-study data were captured from January 2005 MethodEighty continuing medical education (CME) groups (465 GPs) were randomised to receive the educational intervention on GPs' PIPs for older patients (41 CME groups; 256 GPs) or another educational intervention (39 CME groups; 209 GPs); these two groups acted as controls for each other. GPs' prescription data from before and after the intervention were assessed against a list of 13 explicit PIP criteria for patients aged ≥70 years. In the CME groups, trained GPs carried out an educational programme, including an audit, focusing on the 13 criteria and their rationale. ResultsA total of 449 GPs (96.6%) completed the study; 250 in the intervention group and 199 in the control group. After adjusting for baseline differences and clustering effects, a reduction relative to baseline of 10.3% (95% confidence interval = 5.9 to 15.0) PIPs per 100 patients aged ≥70 years was obtained. ConclusionEducational outreach visits with feedback and audit, using GPs as academic detailers in GPs' CME groups, reduced PIPs for older patients aged ≥70 years in general practice.

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“…[1][2][3][4][5] ADRs cause premature deaths in older people, both in hospitals, 6 and in the community. 7 The economic burden of ADRs is considerable.…”

Section: Introductionmentioning

confidence: 99%

Prescription peer academic detailing to reduce inappropriate prescribing for older patients: a cluster randomised controlled trial

Rognstad¹,

Brekke²,

Fetveit³

et al. 2013

Br J Gen Pract

View full text Add to dashboard Cite

show abstract

“…Even though a causal relationship is difficult to establish, the impact of DI can be very relevant. One study indicated that 4% of deaths identified in hospitalized individuals diagnosed with cancer were related to severe DIs (12) .…”

Section: Introductionmentioning

confidence: 99%

Drug interactions of anti-microbial agents used in hematopoietic stem cell transplantation

Guastaldi

Secoli

2011

Rev. Latino-Am. Enfermagem

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This study analyzed potential drug interactions (PDIs) of antimicrobials used in patients of hematopoietic stem cell transplantation and identified associated factors. The sample consisted of 70 patients admitted to a hospital in São Paulo. The PDIs were analyzed through the consultation of the Drug Interactions Facts and Drug Interactions Handbook. Descriptive statistics and logistic regression were used. Half of the sample was exposed to 13 PDIs, which occurred with fluconazole (53.8%), ciprofloxacin (30.8%) and sulfamethoxazole- La mayoría (92,3%) presentó gravedad moderada, inicio de efecto demorado (61,5%) y necesidad de monitorizar la terapia (76,9%). Cuatro o más medicamentos (p<0,001), edad entre 40 y 49 años (p<0,001) y sexo masculino (p<0,001), fueron asociados al riesgo de IMP. Las implicaciones de las IMP pueden resultar en resultados adversos, causando impacto en la morbimortalidad del paciente. Los regímenes combinados pueden ser seguros, desde que exista monitorización cuidadosa por parte de los profesionales envueltos en el cuidado. Interacciones medicamentosas de antimicrobianos utilizados en trasplante de células madre hematopoyéticas

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“…1000 innleggelser. Disse døds-fallene utgjorde 18 prosent av samtlige dødsfall i det aktuelle sykehuset (2,3).…”

Section: Innledningunclassified

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Hem¹

2011

Tidsskriftet

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Fatal adverse drug events: the paradox of drug treatment

Abstract: Buajordet I, Ebbesen J, Erikssen J, Brùrs O, Hilberg T (The

Cited by 56 publications

References 38 publications

Prescription peer academic detailing to reduce inappropriate prescribing for older patients: a cluster randomised controlled trial

Prescription peer academic detailing to reduce inappropriate prescribing for older patients: a cluster randomised controlled trial

Drug interactions of anti-microbial agents used in hematopoietic stem cell transplantation

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